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RNF208 ring finger protein 208 [ Homo sapiens (human) ]

Gene ID: 727800, updated on 2-Nov-2024

Summary

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Official Symbol
RNF208provided by HGNC
Official Full Name
ring finger protein 208provided by HGNC
Primary source
HGNC:HGNC:25420
See related
Ensembl:ENSG00000212864 MIM:618993; AllianceGenome:HGNC:25420
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables ubiquitin-protein transferase activity. Involved in protein autoubiquitination. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See RNF208 in Genome Data Viewer
Location:
9q34.3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (137220259..137223408, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (149457928..149461077, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (140114711..140117860, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20591 Neighboring gene transmembrane protein 203 Neighboring gene NADPH dependent diflavin oxidoreductase 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:140111657-140112396 Neighboring gene ring finger protein-like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:140112397-140113136 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:140113137-140113876 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20592 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20593 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20594 Neighboring gene hESC enhancers GRCh37_chr9:140121623-140122123 and GRCh37_chr9:140122257-140122882 Neighboring gene cysteine rich tail 1 Neighboring gene ring finger protein 224

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Protein microarray characterization of the S-nitrosoproteome. Lee YI, et al. Mol Cell Proteomics, 2014 Jan. PMID 24105792, Free PMC Article
  2. RNF208, an estrogen-inducible E3 ligase, targets soluble Vimentin to suppress metastasis in triple-negative breast cancers. Pang K, et al. Nat Commun, 2019 Dec 20. PMID 31862882, Free PMC Article
  3. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. Woodsmith J, et al. Mol Cell Proteomics, 2012 Jul. PMID 22493164, Free PMC Article
  4. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. Simpson JC, et al. EMBO Rep, 2000 Sep. PMID 11256614, Free PMC Article
  5. Systematic protein-protein interaction mapping for clinically relevant human GPCRs. Sokolina K, et al. Mol Syst Biol, 2017 Mar 15. PMID 28298427, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC88636, DKFZp761H1710

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein autoubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
RING finger protein 208

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001388297.1 → NP_001375226.1  RING finger protein 208 isoform 1

    Status: VALIDATED

    Source sequence(s)
    BX255925
    Consensus CDS
    CCDS7037.2
    UniProtKB/Swiss-Prot
    A2BFA0, Q9H0X6
    Conserved Domains (1) summary
    cd16559
    Location:140 → 193
    RING-HC_RNF208; RING finger, HC subclass, found in RING finger protein 208 (RNF208) and similar proteins

  2. NM_001388298.1 → NP_001375227.1  RING finger protein 208 isoform 1

    Status: VALIDATED

    Source sequence(s)
    BX255925
    Consensus CDS
    CCDS7037.2
    UniProtKB/Swiss-Prot
    A2BFA0, Q9H0X6
    Conserved Domains (1) summary
    cd16559
    Location:140 → 193
    RING-HC_RNF208; RING finger, HC subclass, found in RING finger protein 208 (RNF208) and similar proteins

  3. NM_031297.7 → NP_112587.2  RING finger protein 208 isoform 1

    See identical proteins and their annotated locations for NP_112587.2

    Status: VALIDATED

    Source sequence(s)
    BX255925
    Consensus CDS
    CCDS7037.2
    UniProtKB/Swiss-Prot
    A2BFA0, Q9H0X6
    Related
    ENSP00000375397.1, ENST00000391553.3
    Conserved Domains (1) summary
    cd16559
    Location:140 → 193
    RING-HC_RNF208; RING finger, HC subclass, found in RING finger protein 208 (RNF208) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    137220259..137223408 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    149457928..149461077 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H0X6.2 GenPept UniProtKB/Swiss-Prot:Q9H0X6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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