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CASC8 cancer susceptibility 8 [ Homo sapiens (human) ]

Gene ID: 727677, updated on 10-Oct-2023

Summary

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Official Symbol
CASC8provided by HGNC
Official Full Name
cancer susceptibility 8provided by HGNC
Primary source
HGNC:HGNC:45129
See related
Ensembl:ENSG00000246228 MIM:617701; AllianceGenome:HGNC:45129
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CARLO1; CARLo-1; LINC00860
Expression
Low expression observed in reference dataset See more
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Genomic context

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See CASC8 in Genome Data Viewer
Location:
8q24.21
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (127289676..127482139, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (128416883..128609574, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (128301921..128494384, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene CASC19-CCAT1 intergenic CAGE-defined high expression enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19525 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19526 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27934 Neighboring gene CCAT1 intron CAGE-defined B cell enhancer Neighboring gene Sharpr-MPRA regulatory region 9947 Neighboring gene cancer susceptibility 19 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27936 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128264283-128264878 Neighboring gene colon cancer associated transcript 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27937 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27938 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:128295539-128296172 Neighboring gene cancer susceptibility 21 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:128304713-128305280 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27939 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27940 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:128352096-128353295 Neighboring gene NANOG hESC enhancer GRCh37_chr8:128383298-128383801 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27941 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:128444461-128445375 Neighboring gene POU class 5 homeobox 1B Neighboring gene colon cancer associated transcript 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27942 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27943 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27944 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27945 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19528 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:128620950-128621545 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27946 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr8:128658093-128658594 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr8:128658595-128659094 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:128672691-128673890 Neighboring gene uncharacterized LOC105375754 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:128681305-128681805 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:128717643-128718143 Neighboring gene NANOG hESC enhancer GRCh37_chr8:128744882-128745383 Neighboring gene origin of replication upstream of MYC Neighboring gene cancer susceptibility 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Long non-coding RNA CASC8 polymorphisms are associated with the risk of esophageal cancer in a Chinese population. Sang Y, et al. Thorac Cancer, 2020 Oct. PMID 32875717, Free PMC Article
  2. Significance of LncRNA CASC8 genetic polymorphisms on the tuberculosis susceptibility in Chinese population. Liu G, et al. J Clin Lab Anal, 2020 Jun. PMID 32034808, Free PMC Article
  3. Lack of association of CASC8 rs1447295 with colorectal cancer in Iranian population: A multicenter case-control study. Haerian MS, et al. Gene, 2017 Nov 15. PMID 28887158
  4. Long Noncoding RNA Cancer Susceptibility Candidate 8 Suppresses the Proliferation of Bladder Cancer Cells via Regulating Glycolysis. Hu R, et al. DNA Cell Biol, 2017 Sep. PMID 28759252
  5. Clinical Significance of Long Non-Coding RNA CASC8 rs10505477 Polymorphism in Lung Cancer Susceptibility, Platinum-Based Chemotherapy Response, and Toxicity. Hu L, et al. Int J Environ Res Public Health, 2016 May 30. PMID 27249003, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TCF7L2, CASC8, and GREM1 polymorphism and colorectal cancer in south-eastern Romanian population.
    Title: TCF7L2, CASC8, and GREM1 polymorphism and colorectal cancer in south-eastern Romanian population.
  2. The m6A-induced lncRNA CASC8 promotes proliferation and chemoresistance via upregulation of hnRNPL in esophageal squamous cell carcinoma.
    Title: The m6A-induced lncRNA CASC8 promotes proliferation and chemoresistance via upregulation of hnRNPL in esophageal squamous cell carcinoma.
  3. Association of TCF7L2, CASC8 and GREM1 Polymorphisms in Patients with Colorectal Cancer and Type II Diabetes Mellitus.
    Title: Association of TCF7L2, CASC8 and GREM1 Polymorphisms in Patients with Colorectal Cancer and Type II Diabetes Mellitus.
  4. Contribution of lncRNA CASC8, CASC11, and PVT1 Genetic Variants to the Susceptibility of Coronary Heart Disease.
    Title: Contribution of lncRNA CASC8, CASC11, and PVT1 Genetic Variants to the Susceptibility of Coronary Heart Disease.
  5. Long non-coding RNA CASC8 polymorphisms are associated with the risk of esophageal cancer in a Chinese population.
    Title: Long non-coding RNA CASC8 polymorphisms are associated with the risk of esophageal cancer in a Chinese population.
  6. Significance of LncRNA CASC8 genetic polymorphisms on the tuberculosis susceptibility in Chinese population.
    Title: Significance of LncRNA CASC8 genetic polymorphisms on the tuberculosis susceptibility in Chinese population.
  7. association of CASC8 gene polymorphisms with the occurrence and progression of hepatocellular carcinoma
    Title: Association of lncRNA CCAT2 and CASC8 Gene Polymorphisms with Hepatocellular Carcinoma.
  8. CASC8 reduced the glycolysis of bladder cancer cells via interacting with the fibroblast growth factor receptor 1.
    Title: Long Noncoding RNA Cancer Susceptibility Candidate 8 Suppresses the Proliferation of Bladder Cancer Cells via Regulating Glycolysis.
  9. Results show no association of CASC8 rs1447295 with colorectal cancer in Iranian population.
    Title: Lack of association of CASC8 rs1447295 with colorectal cancer in Iranian population: A multicenter case-control study.
  10. study showed that lncRNA CASC8 rs10505477 polymorphism was significantly related to lung cancer susceptibility and overall severe toxicity induced by platinum-based chemotherapy in lung cancers.
    Title: Clinical Significance of Long Non-Coding RNA CASC8 rs10505477 Polymorphism in Lung Cancer Susceptibility, Platinum-Based Chemotherapy Response, and Toxicity.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic variation in prostate-specific antigen-detected prostate cancer and the effect of control selection on genetic association studies.
EBI GWAS Catalog
Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility.
EBI GWAS Catalog
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.
EBI GWAS Catalog
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Other Names

  • cancer susceptibility 8 (non-protein coding)
  • cancer susceptibility candidate 8 (non-protein coding)
  • long intergenic non-protein coding RNA 860

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_024393.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two exons and contains an alternate 3' terminal exon, resulting in a shorter transcript, compared to variant 1.
    Source sequence(s)
    AC016883
    Related
    ENST00000502056.1

  2. NR_117100.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AC016883, AC018714
    Related
    ENST00000502082.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    127289676..127482139 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    128416883..128609574 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases