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Zcchc12 zinc finger, CCHC domain containing 12 [ Mus musculus (house mouse) ]

Gene ID: 72693, updated on 6-Oct-2024

Summary

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Official Symbol
Zcchc12provided by MGI
Official Full Name
zinc finger, CCHC domain containing 12provided by MGI
Primary source
MGI:MGI:1919943
See related
Ensembl:ENSMUSG00000036699 AllianceGenome:MGI:1919943
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sizn1; 2810028A01Rik
Summary
Enables SUMO binding activity and transcription coactivator activity. Acts upstream of or within BMP signaling pathway and positive regulation of transcription by RNA polymerase II. Located in PML body and nuclear speck. Is expressed in several structures, including central nervous system; gut; paravertebral ganglion; retina; and skeletal musculature. Orthologous to several human genes including ZCCHC12 (zinc finger CCHC-type containing 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 76.9), whole brain E14.5 (RPKM 41.1) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Zcchc12 in Genome Data Viewer
Location:
X A3.3; X 20.58 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (35459553..35462817)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (36195904..36199164)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene dedicator of cytokinesis 11 Neighboring gene interleukin 13 receptor, alpha 1 Neighboring gene predicted gene, 42406 Neighboring gene STARR-seq mESC enhancer starr_46996 Neighboring gene predicted gene 6023 Neighboring gene LON peptidase N-terminal domain and ring finger 3 Neighboring gene predicted gene, 25047

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Human ZCCHC12 activates AP-1 and CREB signaling as a transcriptional co-activator. Li H, et al. Acta Biochim Biophys Sin (Shanghai), 2009 Jul. PMID 19578717
  2. Sizn1 is a novel protein that functions as a transcriptional coactivator of bone morphogenic protein signaling. Cho G, et al. Mol Cell Biol, 2008 Mar. PMID 18160706, Free PMC Article
  3. Zeb2 is a negative regulator of midbrain dopaminergic axon growth and target innervation. Hegarty SV, et al. Sci Rep, 2017 Aug 17. PMID 28819210, Free PMC Article
  4. XLMR candidate mouse gene, Zcchc12 (Sizn1) is a novel marker of Cajal-Retzius cells. Cho G, et al. Gene Expr Patterns, 2011 Mar-Apr. PMID 21172456, Free PMC Article
  5. Fank1 and Jazf1 promote multiciliated cell differentiation in the mouse airway epithelium. Johnson JA, et al. Biol Open, 2018 Apr 16. PMID 29661797, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sizn1 is expressed by Cajal-Retzius neurons of the dorsal forebrain, beginning in their progenitor zones
    Title: XLMR candidate mouse gene, Zcchc12 (Sizn1) is a novel marker of Cajal-Retzius cells.
  2. ZCCHC12 enhanced the transcriptional activities of activator protein 1 (AP-1) and cAMP response element binding protein (CREB) as a coactivator
    Title: Human ZCCHC12 activates AP-1 and CREB signaling as a transcriptional co-activator.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SUMO binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within BMP signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in PML body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger CCHC domain-containing protein 12
Names
smad-interacting zinc finger protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358476.1 → NP_001345405.1  zinc finger CCHC domain-containing protein 12

    Status: VALIDATED

    Source sequence(s)
    AI846160, AL512597, BY099102
    Consensus CDS
    CCDS30058.1
    UniProtKB/Swiss-Prot
    Q9CZA5
    Conserved Domains (1) summary
    pfam14893
    Location:10 → 212
    PNMA

  2. NM_001358477.1 → NP_001345406.1  zinc finger CCHC domain-containing protein 12

    Status: VALIDATED

    Source sequence(s)
    AI846160, AL512597
    Consensus CDS
    CCDS30058.1
    UniProtKB/Swiss-Prot
    Q9CZA5
    Conserved Domains (1) summary
    pfam14893
    Location:10 → 212
    PNMA

  3. NM_001358478.1 → NP_001345407.1  zinc finger CCHC domain-containing protein 12

    Status: VALIDATED

    Source sequence(s)
    AI846160, AL512597, BC055714
    Consensus CDS
    CCDS30058.1
    UniProtKB/Swiss-Prot
    Q9CZA5
    Related
    ENSMUSP00000044550.4, ENSMUST00000048067.10
    Conserved Domains (1) summary
    pfam14893
    Location:10 → 212
    PNMA

  4. NM_001358479.1 → NP_001345408.1  zinc finger CCHC domain-containing protein 12

    Status: VALIDATED

    Source sequence(s)
    AI846160, AL512597
    Consensus CDS
    CCDS30058.1
    UniProtKB/Swiss-Prot
    Q9CZA5
    Conserved Domains (1) summary
    pfam14893
    Location:10 → 212
    PNMA

  5. NM_001358480.1 → NP_001345409.1  zinc finger CCHC domain-containing protein 12

    Status: VALIDATED

    Source sequence(s)
    AI846160, AL512597
    Consensus CDS
    CCDS30058.1
    UniProtKB/Swiss-Prot
    Q9CZA5
    Conserved Domains (1) summary
    pfam14893
    Location:10 → 212
    PNMA

  6. NM_028325.4 → NP_082601.1  zinc finger CCHC domain-containing protein 12

    See identical proteins and their annotated locations for NP_082601.1

    Status: VALIDATED

    Source sequence(s)
    AI846160, AK012833, BY234361
    Consensus CDS
    CCDS30058.1
    UniProtKB/Swiss-Prot
    Q9CZA5
    Related
    ENSMUSP00000110913.3, ENSMUST00000115258.9
    Conserved Domains (1) summary
    pfam14893
    Location:10 → 212
    PNMA

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    35459553..35462817
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162103.1 → XP_036017996.1  zinc finger CCHC domain-containing protein 12 isoform X1

    UniProtKB/Swiss-Prot
    Q9CZA5
    Related
    ENSMUSP00000110911.2, ENSMUST00000115256.2
    Conserved Domains (1) summary
    pfam14893
    Location:10 → 212
    PNMA

  2. XM_036162105.1 → XP_036017998.1  zinc finger CCHC domain-containing protein 12 isoform X1

    UniProtKB/Swiss-Prot
    Q9CZA5
    Conserved Domains (1) summary
    pfam14893
    Location:10 → 212
    PNMA

  3. XM_011250974.4 → XP_011249276.1  zinc finger CCHC domain-containing protein 12 isoform X1

    See identical proteins and their annotated locations for XP_011249276.1

    UniProtKB/Swiss-Prot
    Q9CZA5
    Conserved Domains (1) summary
    pfam14893
    Location:10 → 212
    PNMA

  4. XM_036162104.1 → XP_036017997.1  zinc finger CCHC domain-containing protein 12 isoform X1

    UniProtKB/Swiss-Prot
    Q9CZA5
    Conserved Domains (1) summary
    pfam14893
    Location:10 → 212
    PNMA

  5. XM_006541399.3 → XP_006541462.1  zinc finger CCHC domain-containing protein 12 isoform X1

    See identical proteins and their annotated locations for XP_006541462.1

    UniProtKB/Swiss-Prot
    Q9CZA5
    Conserved Domains (1) summary
    pfam14893
    Location:10 → 212
    PNMA

  6. XM_017318630.3 → XP_017174119.1  zinc finger CCHC domain-containing protein 12 isoform X1

    UniProtKB/Swiss-Prot
    Q9CZA5
    Conserved Domains (1) summary
    pfam14893
    Location:10 → 212
    PNMA
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CZA5.1 GenPept UniProtKB/Swiss-Prot:Q9CZA5

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