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TST thiosulfate sulfurtransferase [ Homo sapiens (human) ]

Gene ID: 7263, updated on 5-Mar-2024

Summary

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Official Symbol
TSTprovided by HGNC
Official Full Name
thiosulfate sulfurtransferaseprovided by HGNC
Primary source
HGNC:HGNC:12388
See related
Ensembl:ENSG00000128311 MIM:180370; AllianceGenome:HGNC:12388
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RDS
Summary
This is one of two neighboring genes encoding similar proteins that each contain two rhodanese domains. The encoded protein is localized to the mitochondria and catalyzes the conversion of thiosulfate and cyanide to thiocyanate and sulfite. In addition, the protein interacts with 5S ribosomal RNA and facilitates its import into the mitochondria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Expression
Broad expression in colon (RPKM 83.2), liver (RPKM 73.2) and 22 other tissues See more
Orthologs
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Genomic context

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See TST in Genome Data Viewer
Location:
22q12.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (37010859..37020183, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (37470450..37479782, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (37406900..37416224, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized protein FLJ39582-like Neighboring gene CRISPRi-validated cis-regulatory element chr22.1656 Neighboring gene CRISPRi-validated cis-regulatory element chr22.1657 Neighboring gene ciliary microtubule inner protein 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:37408066-37408566 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:37408567-37409067 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:37414031-37415006 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:37415035-37415536 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13676 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13675 Neighboring gene mercaptopyruvate sulfurtransferase Neighboring gene uncharacterized LOC112268295 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:37428845-37429362 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:37429455-37430120 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:37439765-37440678 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13677 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:37447950-37448667 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:37448668-37449384 Neighboring gene RN7SK pseudogene 214 Neighboring gene potassium channel tetramerization domain containing 17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Unraveling the role of thiosulfate sulfurtransferase in metabolic diseases. Kruithof PD, et al. Biochim Biophys Acta Mol Basis Dis, 2020 Jun 1. PMID 32061776
  2. Polymorphic Variants of Human Rhodanese Exhibit Differences in Thermal Stability and Sulfur Transfer Kinetics. Libiad M, et al. J Biol Chem, 2015 Sep 25. PMID 26269602, Free PMC Article
  3. Decreased mucosal sulfide detoxification capacity in patients with Crohn's disease. Arijs I, et al. Inflamm Bowel Dis, 2013 Apr. PMID 23399736
  4. Assessment of cassava toxicity in patients with tropical chronic pancreatitis. Girish BN, et al. Trop Gastroenterol, 2011 Apr-Jun. PMID 21922874
  5. Thiol levels, protein carbonylation and anaerobic sulfur metabolism in erythrocytes of peritoneal dialysis and predialysis patients. Włodek P, et al. Nephrology (Carlton), 2010 Dec. PMID 21175961

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Unraveling the role of thiosulfate sulfurtransferase in metabolic diseases.
    Title: Unraveling the role of thiosulfate sulfurtransferase in metabolic diseases.
  2. TST mRNA expression in adipose tissue correlated positively with insulin sensitivity in adipose tissue and negatively with fat mass.
    Title: Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness.
  3. show that polymorphic variations that are distant from the active site differentially modulate the sulfurtransferase activity of human rhodanese to cyanide versus sulfite
    Title: Polymorphic Variants of Human Rhodanese Exhibit Differences in Thermal Stability and Sulfur Transfer Kinetics.
  4. Loss of Thiosulfate Sulfurtransferase is associated with decreased mucosal sulfide detoxification capacity in patients with Crohn's disease
    Title: Decreased mucosal sulfide detoxification capacity in patients with Crohn's disease.
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
  6. silencing of the rhodanese gene caused not only a proportional decrease of 5 S rRNA import but also a general inhibition of mitochondrial translation, indicating the functional importance of the imported 5 S rRNA inside the organelle.
    Title: Mitochondrial enzyme rhodanese is essential for 5 S ribosomal RNA import into human mitochondria.
  7. Proteomics was used to study colonic epithelial aging, for differential proteins in the human normal colonic epithelial tissues from young and old people. Rack1, EF-Tu and Rhodanese, three validated differential proteins, were further investigated.
    Title: Identification of Rack1, EF-Tu and Rhodanese as aging-related proteins in human colonic epithelium by proteomic analysis.
  8. The USP8 recognition domain of NRDP1 has a novel protein fold that interacts with a conserved peptide loop of the rhodanese domain.
    Title: Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8).
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC19578

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3-mercaptopyruvate sulfurtransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 5S rRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables thiosulfate sulfurtransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thiosulfate sulfurtransferase activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in cyanate catabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in epithelial cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in rRNA import into mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sulfur amino acid catabolic process TAS
Traceable Author Statement
more info
  
Component Evidence Code Pubs
located_in extracellular space HDA PubMed 
located_in mitochondrial matrix TAS
Traceable Author Statement
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
thiosulfate sulfurtransferase
Names
epididymis secretory sperm binding protein
thiosulfate sulfurtransferase (rhodanese)
NP_001257412.1
NP_003303.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027994.1 RefSeqGene

    Range
    5004..13586
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001270483.1 → NP_001257412.1  thiosulfate sulfurtransferase

    See identical proteins and their annotated locations for NP_001257412.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AW070418, BQ231617, Z73420
    Consensus CDS
    CCDS13938.1
    UniProtKB/Swiss-Prot
    B3KRM1, Q16762, Q6IB06
    UniProtKB/TrEMBL
    A0A384NKQ2, Q53EW8
    Related
    ENSP00000478739.1, ENST00000622841.1
    Conserved Domains (1) summary
    COG2897
    Location:10 → 279
    SseA; 3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains [Inorganic ion transport and metabolism]

  2. NM_003312.6 → NP_003303.2  thiosulfate sulfurtransferase

    See identical proteins and their annotated locations for NP_003303.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI869664, BC010148
    Consensus CDS
    CCDS13938.1
    UniProtKB/Swiss-Prot
    B3KRM1, Q16762, Q6IB06
    UniProtKB/TrEMBL
    A0A384NKQ2, Q53EW8
    Related
    ENSP00000249042.3, ENST00000249042.8
    Conserved Domains (1) summary
    COG2897
    Location:10 → 279
    SseA; 3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains [Inorganic ion transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    37010859..37020183 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    37470450..37479782 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q16762.4 GenPept UniProtKB/Swiss-Prot:Q16762

Gene LinkOut

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