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Zfp777 zinc finger protein 777 [ Mus musculus (house mouse) ]

Gene ID: 72306, updated on 17-Aug-2024

Summary

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Official Symbol
Zfp777provided by MGI
Official Full Name
zinc finger protein 777provided by MGI
Primary source
MGI:MGI:1919556
See related
Ensembl:ENSMUSG00000071477 AllianceGenome:MGI:1919556
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2500002G23Rik
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Is expressed in several structures, including central nervous system; genitourinary system; retina; and tooth. Orthologous to human ZNF777 (zinc finger protein 777). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 6.7), ovary adult (RPKM 6.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp777 in Genome Data Viewer
Location:
6 B2.3; 6 23.0 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (47994594..48026963, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (48017660..48050004, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15786 Neighboring gene nuclear encoded tRNA cysteine 57 (anticodon GCA) Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_15788 Neighboring gene zinc finger protein 746 Neighboring gene nuclear encoded tRNA cysteine 37 (anticodon GCA) Neighboring gene predicted gene, 30435 Neighboring gene predicted gene, 16630

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
  2. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  3. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein heterooligomerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein 777

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081382.2 → NP_001074851.1  zinc finger protein 777 isoform 1

    See identical proteins and their annotated locations for NP_001074851.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC166290
    Consensus CDS
    CCDS39477.1
    UniProtKB/TrEMBL
    B9EKF4
    Related
    ENSMUSP00000110230.2, ENSMUST00000114583.8
    Conserved Domains (8) summary
    smart00349
    Location:328 → 388
    KRAB; krueppel associated box
    COG5048
    Location:694 → 880
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:750 → 770
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:723 → 740
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:748 → 770
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:328 → 367
    KRAB; KRAB box
    pfam13465
    Location:762 → 786
    zf-H2C2_2; Zinc-finger double domain
    pfam14353
    Location:691 → 740
    CpXC; CpXC protein

  2. NM_001347139.1 → NP_001334068.1  zinc finger protein 777 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC166290
    Consensus CDS
    CCDS85035.1
    UniProtKB/TrEMBL
    G5E8L5
    Conserved Domains (7) summary
    smart00349
    Location:284 → 344
    KRAB; krueppel associated box
    COG5048
    Location:650 → 836
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:706 → 726
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:679 → 696
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:557 → 579
    zf-C2H2; Zinc finger, C2H2 type
    pfam03154
    Location:2 → 180
    Atrophin-1; Atrophin-1 family
    pfam12417
    Location:198 → 254
    DUF3669; Zinc finger protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    47994594..48026963 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506675.4 → XP_006506738.2  zinc finger protein 777 isoform X3

    Conserved Domains (2) summary
    smart00349
    Location:470 → 530
    KRAB; krueppel associated box
    pfam12417
    Location:384 → 440
    DUF3669; Zinc finger protein

  2. XM_006506673.5 → XP_006506736.1  zinc finger protein 777 isoform X2

    See identical proteins and their annotated locations for XP_006506736.1

    UniProtKB/TrEMBL
    G5E8L5
    Related
    ENSMUSP00000093637.4, ENSMUST00000095944.10
    Conserved Domains (7) summary
    smart00349
    Location:284 → 344
    KRAB; krueppel associated box
    COG5048
    Location:650 → 836
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:706 → 726
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:679 → 696
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:557 → 579
    zf-C2H2; Zinc finger, C2H2 type
    pfam03154
    Location:2 → 180
    Atrophin-1; Atrophin-1 family
    pfam12417
    Location:198 → 254
    DUF3669; Zinc finger protein

  3. XM_011241478.4 → XP_011239780.1  zinc finger protein 777 isoform X2

    See identical proteins and their annotated locations for XP_011239780.1

    UniProtKB/TrEMBL
    G5E8L5
    Conserved Domains (7) summary
    smart00349
    Location:284 → 344
    KRAB; krueppel associated box
    COG5048
    Location:650 → 836
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:706 → 726
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:679 → 696
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:557 → 579
    zf-C2H2; Zinc finger, C2H2 type
    pfam03154
    Location:2 → 180
    Atrophin-1; Atrophin-1 family
    pfam12417
    Location:198 → 254
    DUF3669; Zinc finger protein

  4. XM_006506674.5 → XP_006506737.1  zinc finger protein 777 isoform X2

    See identical proteins and their annotated locations for XP_006506737.1

    UniProtKB/TrEMBL
    G5E8L5
    Conserved Domains (7) summary
    smart00349
    Location:284 → 344
    KRAB; krueppel associated box
    COG5048
    Location:650 → 836
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:706 → 726
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:679 → 696
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:557 → 579
    zf-C2H2; Zinc finger, C2H2 type
    pfam03154
    Location:2 → 180
    Atrophin-1; Atrophin-1 family
    pfam12417
    Location:198 → 254
    DUF3669; Zinc finger protein

  5. XM_006506671.5 → XP_006506734.1  zinc finger protein 777 isoform X1

    Conserved Domains (7) summary
    smart00349
    Location:307 → 367
    KRAB; krueppel associated box
    COG5048
    Location:673 → 859
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:729 → 749
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:702 → 719
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:580 → 602
    zf-C2H2; Zinc finger, C2H2 type
    pfam03154
    Location:14 → 203
    Atrophin-1; Atrophin-1 family
    pfam12417
    Location:221 → 277
    DUF3669; Zinc finger protein

RNA

  1. XR_003956255.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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