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Klhl35 kelch-like 35 [ Mus musculus (house mouse) ]

Gene ID: 72184, updated on 2-Nov-2024

Summary

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Official Symbol
Klhl35provided by MGI
Official Full Name
kelch-like 35provided by MGI
Primary source
MGI:MGI:1919434
See related
Ensembl:ENSMUSG00000035298 AllianceGenome:MGI:1919434
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810406K13Rik
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in diencephalon lateral wall ventricular layer; midbrain ventricular layer; pons ventricular layer; rest of cerebellum ventricular layer; and spinal cord ventricular layer. Orthologous to human KLHL35 (kelch like family member 35). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 7.2), whole brain E14.5 (RPKM 3.3) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Klhl35 in Genome Data Viewer
Location:
7 E1; 7 54.07 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (99112328..99123229)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (99463121..99474022)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_19650 Neighboring gene serine (or cysteine) peptidase inhibitor, clade H, member 1 Neighboring gene STARR-positive B cell enhancer ABC_E4952 Neighboring gene STARR-positive B cell enhancer ABC_E1346 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 5 Neighboring gene STARR-seq mESC enhancer starr_19652 Neighboring gene STARR-seq mESC enhancer starr_19653 Neighboring gene STARR-seq mESC enhancer starr_19654 Neighboring gene STARR-seq mESC enhancer starr_19655 Neighboring gene small nucleolar RNA, C/D box 15B Neighboring gene small nucleolar RNA, C/D box 15A Neighboring gene ribosomal protein S3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks. Xu G, et al. Mol Cell Proteomics, 2014 Feb. PMID 24319055, Free PMC Article
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kelch-like protein 35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028145.1 → NP_082421.1  kelch-like protein 35

    See identical proteins and their annotated locations for NP_082421.1

    Status: VALIDATED

    Source sequence(s)
    AK013012, BE994913, BM933902, BQ573536
    Consensus CDS
    CCDS52320.1
    UniProtKB/Swiss-Prot
    E9QMG1, Q9CZ49
    Related
    ENSMUSP00000041363.3, ENSMUST00000037359.9
    Conserved Domains (6) summary
    smart00612
    Location:386 → 432
    Kelch; Kelch domain
    smart00225
    Location:41 → 141
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00038
    Location:331 → 371
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:30 → 137
    BTB; BTB/POZ domain
    pfam01344
    Location:331 → 371
    Kelch_1; Kelch motif
    pfam07707
    Location:163 → 248
    BACK; BTB And C-terminal Kelch

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    99112328..99123229
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508220.4 → XP_006508283.1  kelch-like protein 35 isoform X1

    Conserved Domains (4) summary
    PHA03098
    Location:170 → 516
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:331 → 371
    Kelch; KELCH repeat [structural motif]
    cd18265
    Location:17 → 148
    BTB_POZ_KLHL35; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35)
    cl28903
    Location:171 → 254
    BACK; BACK (BTB and C-terminal Kelch) domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CZ49.2 GenPept UniProtKB/Swiss-Prot:Q9CZ49

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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