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Tdrp testis development related protein [ Mus musculus (house mouse) ]

Gene ID: 72148, updated on 2-Nov-2024

Summary

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Official Symbol
Tdrpprovided by MGI
Official Full Name
testis development related proteinprovided by MGI
Primary source
MGI:MGI:1919398
See related
Ensembl:ENSMUSG00000050052 AllianceGenome:MGI:1919398
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610019F03Rik
Summary
Predicted to be involved in spermatogenesis. Predicted to be located in cytoplasm and intracellular membrane-bounded organelle. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including brain; ileum; immune system; reproductive system; and trigeminal nerve. Orthologous to human TDRP (testis development related protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis adult (RPKM 15.0), genital fat pad adult (RPKM 14.6) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Tdrp in Genome Data Viewer
Location:
8 A1.1; 8 6.44 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (14002008..14025484, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (13952008..13975478, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr8:13907572-13907873 Neighboring gene interferon induced transmembrane protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_20776 Neighboring gene F-box protein 25 Neighboring gene STARR-seq mESC enhancer starr_20780 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:13992606-13992862 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:13996330-13996563 Neighboring gene predicted gene 5907 Neighboring gene predicted gene, 53401 Neighboring gene STARR-seq mESC enhancer starr_20785 Neighboring gene glutamate rich 1 Neighboring gene predicted gene, 57788

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Immuno-moodulin: A new anxiogenic factor produced by Annexin-A1 transgenic autoimmune-prone T cells. Piras G, et al. Brain Behav Immun, 2020 Jul. PMID 32126289
  2. TDRP deficiency contributes to low sperm motility and is a potential risk factor for male infertility. Mao S, et al. Am J Transl Res, 2016. PMID 27069551, Free PMC Article
  3. Molecular cloning of a novel nuclear factor, TDRP1, in spermatogenic cells of testis and its relationship with spermatogenesis. Wang X, et al. Biochem Biophys Res Commun, 2010 Mar 26. PMID 20170638
  4. 140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry. Berggård T, et al. J Proteome Res, 2006 Mar. PMID 16512683
  5. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (4)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spermatogenesis ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
testis development-related protein
Names
immuno-moodulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361625.2 → NP_001348554.1  testis development-related protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC139186
    UniProtKB/TrEMBL
    B7ZNJ7
    Conserved Domains (1) summary
    pfam15683
    Location:45 → 190
    TDRP; Testis development-related protein

  2. NM_001361628.2 → NP_001348557.1  testis development-related protein isoform b

    Status: VALIDATED

    Source sequence(s)
    AC139186
    Consensus CDS
    CCDS22119.1
    UniProtKB/Swiss-Prot
    Q3TQC8, Q8C5P7
    Conserved Domains (1) summary
    pfam15683
    Location:38 → 182
    TDRP; Testis development-related protein

  3. NM_001361629.2 → NP_001348558.1  testis development-related protein isoform b

    Status: VALIDATED

    Source sequence(s)
    AC139186
    Consensus CDS
    CCDS22119.1
    UniProtKB/Swiss-Prot
    Q3TQC8, Q8C5P7
    Conserved Domains (1) summary
    pfam15683
    Location:38 → 182
    TDRP; Testis development-related protein

  4. NM_001361630.2 → NP_001348559.1  testis development-related protein isoform b

    Status: VALIDATED

    Source sequence(s)
    AC139186
    Consensus CDS
    CCDS22119.1
    UniProtKB/Swiss-Prot
    Q3TQC8, Q8C5P7
    Conserved Domains (1) summary
    pfam15683
    Location:38 → 182
    TDRP; Testis development-related protein

  5. NM_173744.5 → NP_776105.1  testis development-related protein isoform b

    See identical proteins and their annotated locations for NP_776105.1

    Status: VALIDATED

    Source sequence(s)
    AC139186
    Consensus CDS
    CCDS22119.1
    UniProtKB/Swiss-Prot
    Q3TQC8, Q8C5P7
    Related
    ENSMUSP00000058371.5, ENSMUST00000062613.12
    Conserved Domains (1) summary
    pfam15683
    Location:38 → 182
    TDRP; Testis development-related protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    14002008..14025484 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242083.4 → XP_011240385.1  testis development-related protein isoform X1

    Conserved Domains (1) summary
    pfam15683
    Location:109 → 254
    TDRP; Testis development-related protein

  2. XM_011242084.2 → XP_011240386.1  testis development-related protein isoform X2

    See identical proteins and their annotated locations for XP_011240386.1

    Conserved Domains (1) summary
    pfam15683
    Location:57 → 202
    TDRP; Testis development-related protein

  3. XM_011242085.4 → XP_011240387.1  testis development-related protein isoform X2

    See identical proteins and their annotated locations for XP_011240387.1

    Conserved Domains (1) summary
    pfam15683
    Location:57 → 202
    TDRP; Testis development-related protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C5P7.1 GenPept UniProtKB/Swiss-Prot:Q8C5P7

Gene LinkOut

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