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Dscc1 DNA replication and sister chromatid cohesion 1 [ Mus musculus (house mouse) ]

Gene ID: 72107, updated on 2-Nov-2024

Summary

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Official Symbol
Dscc1provided by MGI
Official Full Name
DNA replication and sister chromatid cohesion 1provided by MGI
Primary source
MGI:MGI:1919357
See related
Ensembl:ENSMUSG00000022422 AllianceGenome:MGI:1919357
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dcc1; 2010006I05Rik; 2600005O03Rik
Summary
Predicted to enable DNA binding activity. Predicted to contribute to DNA clamp loader activity and single-stranded DNA helicase activity. Predicted to be involved in maintenance of mitotic sister chromatid cohesion; positive regulation of DNA-directed DNA polymerase activity; and post-translational protein acetylation. Predicted to be located in chromatin and nucleoplasm. Predicted to be part of Ctf18 RFC-like complex. Predicted to be active in chromosome, centromeric region. Is expressed in brain. Orthologous to human DSCC1 (DNA replication and sister chromatid cohesion 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver E14 (RPKM 4.6), CNS E11.5 (RPKM 4.2) and 14 other tissues See more
Orthologs
human all
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Genomic context

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See Dscc1 in Genome Data Viewer
Location:
15 D1; 15 21.96 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (54939497..54953887, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (55076101..55090491, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene 2491 Neighboring gene TATA-box binding protein associated factor 2 Neighboring gene STARR-positive B cell enhancer mm9_chr15:54903568-54903869 Neighboring gene predicted gene, 41325 Neighboring gene STARR-positive B cell enhancer ABC_E3139 Neighboring gene predicted gene 9920 Neighboring gene DEP domain containing MTOR-interacting protein Neighboring gene predicted gene, 26296

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. An atlas of genetic influences on osteoporosis in humans and mice. Morris JA, et al. Nat Genet, 2019 Feb. PMID 30598549, Free PMC Article
  2. Keratin 13 deficiency causes white sponge nevus in mice. Simonson L, et al. Dev Biol, 2020 Dec 1. PMID 32758484, Free PMC Article
  3. A staging system for correct phenotype interpretation of mouse embryos harvested on embryonic day 14 (E14.5). Geyer SH, et al. J Anat, 2017 May. PMID 28185240, Free PMC Article
  4. Molecular Profiling Reveals Involvement of ESCO2 in Intermediate Progenitor Cell Maintenance in the Developing Mouse Cortex. Ulmke PA, et al. Stem Cell Reports, 2021 Apr 13. PMID 33798452, Free PMC Article
  5. Genes expressed in Atoh1 neuronal lineages arising from the r1/isthmus rhombic lip. Machold R, et al. Gene Expr Patterns, 2011 Jun-Jul. PMID 21440680, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC151210, MGC151212

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to DNA clamp loader activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to DNA clamp loader activity ISS
Inferred from Sequence or Structural Similarity
more info
  
contributes_to single-stranded DNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to single-stranded DNA helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in maintenance of mitotic sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maintenance of mitotic sister chromatid cohesion ISO
Inferred from Sequence Orthology
more info
  
involved_in maintenance of mitotic sister chromatid cohesion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of DNA-directed DNA polymerase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-directed DNA polymerase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in post-translational protein acetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in post-translational protein acetylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA replication ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of Ctf18 RFC-like complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Ctf18 RFC-like complex ISO
Inferred from Sequence Orthology
more info
  
part_of Ctf18 RFC-like complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in chromatin ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in chromosome, centromeric region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome, centromeric region ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sister chromatid cohesion protein DCC1
Names
defective in sister chromatid cohesion 1 homolog
defective in sister chromatid cohesion protein 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355594.1 → NP_001342523.1  sister chromatid cohesion protein DCC1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC137950
    Consensus CDS
    CCDS88764.1
    UniProtKB/TrEMBL
    D3YVY9
    Related
    ENSMUSP00000105860.2, ENSMUST00000110231.2
    Conserved Domains (1) summary
    pfam09724
    Location:49 → 426
    DUF2036; Uncharacterized conserved protein (DUF2036)

  2. NM_183089.3 → NP_898912.2  sister chromatid cohesion protein DCC1 isoform 2

    See identical proteins and their annotated locations for NP_898912.2

    Status: VALIDATED

    Source sequence(s)
    AC137950
    Consensus CDS
    CCDS27473.1
    UniProtKB/Swiss-Prot
    Q14AI0, Q4FZL5
    Related
    ENSMUSP00000023059.7, ENSMUST00000023059.13
    Conserved Domains (1) summary
    pfam09724
    Location:49 → 363
    DUF2036; Uncharacterized conserved protein (DUF2036)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    54939497..54953887 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14AI0.1 GenPept UniProtKB/Swiss-Prot:Q14AI0

Gene LinkOut

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