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CCT3 chaperonin containing TCP1 subunit 3 [ Homo sapiens (human) ]

Gene ID: 7203, updated on 7-Apr-2024

Summary

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Official Symbol
CCT3provided by HGNC
Official Full Name
chaperonin containing TCP1 subunit 3provided by HGNC
Primary source
HGNC:HGNC:1616
See related
Ensembl:ENSG00000163468 MIM:600114; AllianceGenome:HGNC:1616
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCTG; PIG48; TRIC5; CCT-gamma; TCP-1-gamma
Summary
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants have been characterized for this gene. In addition, a pseudogene of this gene has been found on chromosome 8. [provided by RefSeq, Aug 2010]
Expression
Ubiquitous expression in testis (RPKM 72.7), adrenal (RPKM 56.4) and 25 other tissues See more
Orthologs
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Genomic context

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See CCT3 in Genome Data Viewer
Location:
1q22
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (156308968..156338292, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (155447437..155476903, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156278759..156308083, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156271210-156271710 Neighboring gene MPRA-validated peak424 silencer Neighboring gene glycosylated lysosomal membrane protein Neighboring gene VHL like Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156297025-156297871 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:156297872-156298717 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1858 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1859 Neighboring gene TSSK6 activating cochaperone Neighboring gene Rh family B glycoprotein Neighboring gene Sharpr-MPRA regulatory region 198 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156362688-156363193 Neighboring gene CRISPRi-validated cis-regulatory element chr1.9068 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156369951-156370626 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156371301-156371974 Neighboring gene MIR9-1 host gene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156382372-156382872 Neighboring gene microRNA 9-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Integrated analyzes identify CCT3 as a modulator to shape immunosuppressive tumor microenvironment in lung adenocarcinoma. Huang J, et al. BMC Cancer, 2023 Mar 14. PMID 36918801, Free PMC Article
  2. Upregulation of CCT3 predicts poor prognosis and promotes cell proliferation via inhibition of ferroptosis and activation of AKT signaling in lung adenocarcinoma. Wang K, et al. BMC Mol Cell Biol, 2022 Jun 30. PMID 35773623, Free PMC Article
  3. Identification of CCT3 as a prognostic factor and correlates with cell survival and invasion of head and neck squamous cell carcinoma. Wang Y, et al. Biosci Rep, 2021 Oct 29. PMID 34505628, Free PMC Article
  4. CCT3 suppression prompts apoptotic machinery through oxidative stress and energy deprivation in breast and prostate cancers. Temiz E, et al. Free Radic Biol Med, 2021 Mar. PMID 33508424
  5. High expression of chaperonin-containing TCP1 subunit 3 may induce dismal prognosis in multiple myeloma. Qian T, et al. Pharmacogenomics J, 2020 Aug. PMID 31902948

See all (298) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Circular RNA CCT3 is a unique molecular marker in bladder cancer.
    Title: Circular RNA CCT3 is a unique molecular marker in bladder cancer.
  2. m[6]A-modification regulated circ-CCT3 acts as the sponge of miR-378a-3p to promote hepatocellular carcinoma progression.
    Title: m(6)A-modification regulated circ-CCT3 acts as the sponge of miR-378a-3p to promote hepatocellular carcinoma progression.
  3. Integrated analyzes identify CCT3 as a modulator to shape immunosuppressive tumor microenvironment in lung adenocarcinoma.
    Title: Integrated analyzes identify CCT3 as a modulator to shape immunosuppressive tumor microenvironment in lung adenocarcinoma.
  4. Upregulation of CCT3 predicts poor prognosis and promotes cell proliferation via inhibition of ferroptosis and activation of AKT signaling in lung adenocarcinoma.
    Title: Upregulation of CCT3 predicts poor prognosis and promotes cell proliferation via inhibition of ferroptosis and activation of AKT signaling in lung adenocarcinoma.
  5. Chaperonin containing TCP1 subunit 3 (CCT3) promotes cisplatin resistance of lung adenocarcinoma cells through targeting the Janus kinase 2/signal transducers and activators of transcription 3 (JAK2/STAT3) pathway.
    Title: Chaperonin containing TCP1 subunit 3 (CCT3) promotes cisplatin resistance of lung adenocarcinoma cells through targeting the Janus kinase 2/signal transducers and activators of transcription 3 (JAK2/STAT3) pathway.
  6. Identification of CCT3 as a prognostic factor and correlates with cell survival and invasion of head and neck squamous cell carcinoma.
    Title: Identification of CCT3 as a prognostic factor and correlates with cell survival and invasion of head and neck squamous cell carcinoma.
  7. Upregulation of CCT3 promotes cervical cancer progression through FN1.
    Title: Upregulation of CCT3 promotes cervical cancer progression through FN1.
  8. CCT3 suppression prompts apoptotic machinery through oxidative stress and energy deprivation in breast and prostate cancers.
    Title: CCT3 suppression prompts apoptotic machinery through oxidative stress and energy deprivation in breast and prostate cancers.
  9. High expression of chaperonin-containing TCP1 subunit 3 may induce dismal prognosis in multiple myeloma.
    Title: High expression of chaperonin-containing TCP1 subunit 3 may induce dismal prognosis in multiple myeloma.
  10. CCT3 acts upstream of YAP and TFCP2 as a potential target and tumour biomarker in liver cancer.
    Title: CCT3 acts upstream of YAP and TFCP2 as a potential target and tumour biomarker in liver cancer.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
EBI GWAS Catalog
Genome-wide association study of hematological and biochemical traits in a Japanese population.
EBI GWAS Catalog
Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif interacts with CCT3 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein folding chaperone IDA
Inferred from Direct Assay
more info
 PubMed 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in binding of sperm to zona pellucida IEA
Inferred from Electronic Annotation
more info
  
involved_in chaperone-mediated protein folding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of establishment of protein localization to telomere IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein localization to Cajal body HMP PubMed 
involved_in positive regulation of telomerase RNA localization to Cajal body HMP PubMed 
involved_in positive regulation of telomere maintenance via telomerase IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein stabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell body IEA
Inferred from Electronic Annotation
more info
  
part_of chaperonin-containing T-complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chaperonin-containing T-complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of chaperonin-containing T-complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of chaperonin-containing T-complex TAS
Traceable Author Statement
more info
 PubMed 
located_in cytoskeleton TAS
Traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
part_of zona pellucida receptor complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
T-complex protein 1 subunit gamma
Names
T-complex protein 1, gamma subunit
TCP1 (t-complex-1) ring complex, polypeptide 5
chaperonin containing TCP1, subunit 3 (gamma)
hTRiC5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008800.3 → NP_001008800.1  T-complex protein 1 subunit gamma isoform c

    See identical proteins and their annotated locations for NP_001008800.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons, compared to variant 1, resulting in a shorter protein (isoform c), compared to isoform a.
    Source sequence(s)
    AK126400, AK293477, BG476176
    Consensus CDS
    CCDS30888.1
    UniProtKB/TrEMBL
    Q2TU64
    Related
    ENSP00000357242.2, ENST00000368259.6
    Conserved Domains (2) summary
    cd03337
    Location:6 → 487
    TCP1_gamma; TCP-1 (CTT or eukaryotic type II) chaperonin family, gamma subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
    TIGR02344
    Location:6 → 491
    chap_CCT_gamma; T-complex protein 1, gamma subunit

  2. NM_005998.5 → NP_005989.3  T-complex protein 1 subunit gamma isoform a

    See identical proteins and their annotated locations for NP_005989.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AB208882, AK126400, BG476176
    Consensus CDS
    CCDS1140.2
    UniProtKB/Swiss-Prot
    A6NE14, P49368, Q5SZY1, Q9BR64
    UniProtKB/TrEMBL
    Q2TU64
    Related
    ENSP00000295688.3, ENST00000295688.8
    Conserved Domains (1) summary
    TIGR02344
    Location:6 → 529
    chap_CCT_gamma; T-complex protein 1, gamma subunit

RNA

  1. NR_036564.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK126400, AK300765, BG476176
    Related
    ENST00000368262.7

  2. NR_036565.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK126400, AK316387, BG476176
    Related
    ENST00000472765.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    156308968..156338292 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    155447437..155476903 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001008883.1: Suppressed sequence

    Description
    NM_001008883.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49368.4 GenPept UniProtKB/Swiss-Prot:P49368

Gene LinkOut

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