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Cnn3 calponin 3, acidic [ Mus musculus (house mouse) ]

Gene ID: 71994, updated on 2-Nov-2024

Summary

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Official Symbol
Cnn3provided by MGI
Official Full Name
calponin 3, acidicprovided by MGI
Primary source
MGI:MGI:1919244
See related
Ensembl:ENSMUSG00000053931 AllianceGenome:MGI:1919244
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Calpo3; 1600014M03Rik
Summary
Predicted to enable actin filament binding activity and microtubule binding activity. Predicted to be involved in actin filament organization. Predicted to be located in cytosol; dendritic spine; and neuronal cell body. Predicted to be active in actin cytoskeleton; glutamatergic synapse; and postsynapse. Is expressed in several structures, including body cavity or lining; dentate gyrus subgranular zone; genitourinary system; respiratory system; and vertebral axis musculature. Orthologous to human CNN3 (calponin 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in limb E14.5 (RPKM 221.9), ovary adult (RPKM 202.5) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Cnn3 in Genome Data Viewer
Location:
3 G1; 3 52.94 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (121220190..121251854)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (121426541..121458205)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08839 Neighboring gene predicted gene, 33363 Neighboring gene STARR-seq mESC enhancer starr_08840 Neighboring gene peptidylprolyl isomerase A pseudogene 3_1234.1 Neighboring gene predicted gene, 40134 Neighboring gene STARR-seq mESC enhancer starr_08841 Neighboring gene STARR-seq mESC enhancer starr_08842 Neighboring gene STARR-positive B cell enhancer mm9_chr3:121129235-121129536 Neighboring gene solute carrier family 44, member 3 Neighboring gene RIKEN cDNA A530020G20 gene Neighboring gene STARR-positive B cell enhancer mm9_chr3:121238792-121239093 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:121250785-121250968 Neighboring gene STARR-seq mESC enhancer starr_08854 Neighboring gene STARR-seq mESC enhancer starr_08855 Neighboring gene predicted gene, 33547

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Rock-dependent calponin 3 phosphorylation regulates myoblast fusion. Shibukawa Y, et al. Exp Cell Res, 2013 Mar 10. PMID 23276748
  2. Calponin 3 regulates actin cytoskeleton rearrangement in trophoblastic cell fusion. Shibukawa Y, et al. Mol Biol Cell, 2010 Nov 15. PMID 20861310, Free PMC Article
  3. A Conditional Knockout Mouse Model Reveals That Calponin-3 Is Dispensable for Early B Cell Development. Flemming A, et al. PLoS One, 2015. PMID 26046660, Free PMC Article
  4. Calponin-3 deficiency augments contractile activity, plasticity, fibrogenic response and Yap/Taz transcriptional activation in lens epithelial cells and explants. Maddala R, et al. Sci Rep, 2020 Jan 28. PMID 31992794, Free PMC Article
  5. Cnn3 regulates neural tube morphogenesis and neuronal stem cell properties. Junghans D, et al. FEBS J, 2018 Jan. PMID 29151265

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results reveal that CNN3 plays a crucial role in regulating lens epithelial contractile activity and provide supporting evidence that CNN-3 deficiency is associated with the induction of epithelial plasticity, fibrogenic activity and mechanosensitive Yap/Taz (Wwtr1) transcriptional activation.
    Title: Calponin-3 deficiency augments contractile activity, plasticity, fibrogenic response and Yap/Taz transcriptional activation in lens epithelial cells and explants.
  2. provides evidence for an important role of Cnn3 during development of the embryonic brain and in regulating NSC function
    Title: Cnn3 regulates neural tube morphogenesis and neuronal stem cell properties.
  3. h3/acidic calponin controls fibroblast migration by regulation of ERK1/2-mediated l-caldesmon phosphorylation.
    Title: h3/Acidic calponin: an actin-binding protein that controls extracellular signal-regulated kinase 1/2 activity in nonmuscle cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actomyosin structure organization IEA
Inferred from Electronic Annotation
more info
  
involved_in epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
  
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
  
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
calponin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028044.2 → NP_082320.1  calponin-3

    See identical proteins and their annotated locations for NP_082320.1

    Status: PROVISIONAL

    Source sequence(s)
    AK005460
    Consensus CDS
    CCDS17802.1
    UniProtKB/Swiss-Prot
    Q3TW23, Q9DAW9
    UniProtKB/TrEMBL
    A0A0G2JDV8
    Related
    ENSMUSP00000029773.9, ENSMUST00000029773.13
    Conserved Domains (2) summary
    cd00014
    Location:28 → 125
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00402
    Location:164 → 187
    Calponin; Calponin family repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    121220190..121251854
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DAW9.1 GenPept UniProtKB/Swiss-Prot:Q9DAW9

Gene LinkOut

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