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Tdrd12 tudor domain containing 12 [ Mus musculus (house mouse) ]

Gene ID: 71981, updated on 2-Nov-2024

Summary

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Official Symbol
Tdrd12provided by MGI
Official Full Name
tudor domain containing 12provided by MGI
Primary source
MGI:MGI:1919231
See related
Ensembl:ENSMUSG00000030491 AllianceGenome:MGI:1919231
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ECAT8; repro23; EG434165; G1-476-14; 2410004F06Rik; 2410070K17Rik
Summary
Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and RNA helicase activity. Involved in several processes, including male meiotic nuclear division; regulatory ncRNA-mediated gene silencing; and spermatogenesis. Part of PET complex. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system gland; and sensory organ. Orthologous to human TDRD12 (tudor domain containing 12). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 4.7), kidney adult (RPKM 0.5) and 2 other tissues See more
Orthologs
human all
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Genomic context

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See Tdrd12 in Genome Data Viewer
Location:
7 B2; 7 21.37 cM
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (35166366..35237206, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (35466941..35537784, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42378 Neighboring gene SCAN domain containing 3 pseudogene Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member 9 Neighboring gene stress-induced phosphoprotein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_18633 Neighboring gene nudix hydrolase 19 Neighboring gene regulator of G-protein signalling 9 binding protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization and linkage mapping of an ENU-induced mutant mouse with defective spermatogenesis. Asano Y, et al. Exp Anim, 2009 Oct. PMID 19897936
  2. Exonuclease Domain-Containing 1 Enhances MIWI2 piRNA Biogenesis via Its Interaction with TDRD12. Pandey RR, et al. Cell Rep, 2018 Sep 25. PMID 30257204
  3. PIWI Slicing and EXD1 Drive Biogenesis of Nuclear piRNAs from Cytosolic Targets of the Mouse piRNA Pathway. Yang Z, et al. Mol Cell, 2016 Jan 7. PMID 26669262, Free PMC Article
  4. Unpackaging the genetics of mammalian fertility: strategies to identify the "reproductive genome". Schimenti JC, et al. Biol Reprod, 2018 Dec 1. PMID 29878059
  5. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Mitsui K, et al. Cell, 2003 May 30. PMID 12787504

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice.
    Title: Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in fertilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ-line stem cell division IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in male meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in piRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retrotransposon silencing by piRNA-directed DNA methylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of PET complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
putative ATP-dependent RNA helicase TDRD12
Names
ES cell associated transcript 8
ES cell-associated transcript 8 protein
tudor domain-containing protein 12
NP_001355316.1
NP_082310.1
XP_011249006.1
XP_011249009.1
XP_030098858.1
XP_030098859.1
XP_030098860.1
XP_030098861.1
XP_030098862.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368387.1 → NP_001355316.1  putative ATP-dependent RNA helicase TDRD12 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC151535
    UniProtKB/Swiss-Prot
    Q9CWU0
    Related
    ENSMUSP00000141796.3, ENSMUST00000193633.6

  2. NM_028034.2 → NP_082310.1  putative ATP-dependent RNA helicase TDRD12 isoform 1

    See identical proteins and their annotated locations for NP_082310.1

    Status: VALIDATED

    Source sequence(s)
    AK010386, AK010714, CJ078592
    Consensus CDS
    CCDS21151.1
    UniProtKB/TrEMBL
    A0A0U1RNL0
    Related
    ENSMUSP00000032701.8, ENSMUST00000032701.14
    Conserved Domains (2) summary
    cd04508
    Location:60 → 109
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:2 → 129
    TUDOR; Tudor domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    35166366..35237206 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243001.2 → XP_030098861.1  putative ATP-dependent RNA helicase TDRD12 isoform X3

    UniProtKB/Swiss-Prot
    Q9CWU0
    Conserved Domains (3) summary
    COG0513
    Location:391 → 665
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    pfam00567
    Location:3 → 128
    TUDOR; Tudor domain
    cl00175
    Location:1074 → 1178
    alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.

  2. XM_030242998.2 → XP_030098858.1  putative ATP-dependent RNA helicase TDRD12 isoform X1

    UniProtKB/TrEMBL
    A0A087WQS9
    Related
    ENSMUSP00000140328.4, ENSMUST00000187190.7
    Conserved Domains (3) summary
    cd06463
    Location:1139 → 1179
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    COG0513
    Location:391 → 729
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    pfam00567
    Location:3 → 128
    TUDOR; Tudor domain

  3. XM_030242999.1 → XP_030098859.1  putative ATP-dependent RNA helicase TDRD12 isoform X2

    UniProtKB/Swiss-Prot
    Q9CWU0
    Conserved Domains (3) summary
    COG0513
    Location:353 → 691
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    pfam00567
    Location:1 → 90
    TUDOR; Tudor domain
    cl00175
    Location:1100 → 1204
    alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.

  4. XM_030243000.1 → XP_030098860.1  putative ATP-dependent RNA helicase TDRD12 isoform X2

    UniProtKB/Swiss-Prot
    Q9CWU0
    Conserved Domains (3) summary
    COG0513
    Location:353 → 691
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    pfam00567
    Location:1 → 90
    TUDOR; Tudor domain
    cl00175
    Location:1100 → 1204
    alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.

  5. XM_030243002.2 → XP_030098862.1  putative ATP-dependent RNA helicase TDRD12 isoform X4

    Conserved Domains (3) summary
    COG0513
    Location:119 → 457
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    pfam00567
    Location:584 → 699
    TUDOR; Tudor domain
    cl00175
    Location:866 → 970
    alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.

  6. XM_011250704.4 → XP_011249006.1  putative ATP-dependent RNA helicase TDRD12 isoform X5

    Conserved Domains (2) summary
    COG0513
    Location:391 → 729
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    pfam00567
    Location:3 → 128
    TUDOR; Tudor domain

  7. XM_011250707.4 → XP_011249009.1  putative ATP-dependent RNA helicase TDRD12 isoform X6

    Conserved Domains (2) summary
    COG0513
    Location:391 → 692
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    pfam00567
    Location:3 → 128
    TUDOR; Tudor domain

RNA

  1. XR_001778000.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001082581.1: Suppressed sequence

    Description
    NM_001082581.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CWU0.2 GenPept UniProtKB/Swiss-Prot:Q9CWU0

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