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Apol6 apolipoprotein L 6 [ Mus musculus (house mouse) ]

Gene ID: 71939, updated on 2-Nov-2024

Summary

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Official Symbol
Apol6provided by MGI
Official Full Name
apolipoprotein L 6provided by MGI
Primary source
MGI:MGI:1919189
See related
Ensembl:ENSMUSG00000033576 AllianceGenome:MGI:1919189
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310076O14Rik
Summary
Predicted to enable lipid binding activity. Orthologous to human APOL6 (apolipoprotein L6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in subcutaneous fat pad adult (RPKM 49.6), genital fat pad adult (RPKM 29.2) and 4 other tissues See more
Orthologs
human all
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Genomic context

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See Apol6 in Genome Data Viewer
Location:
15 D3; 15 36.39 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76929195..76941308)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (77045050..77057108)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53916 Neighboring gene predicted gene, 52199 Neighboring gene VISTA enhancer mm106 Neighboring gene STARR-seq mESC enhancer starr_39074 Neighboring gene myoglobin Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:76901831-76902180 Neighboring gene predicted gene, 24753 Neighboring gene predicted gene, 53899 Neighboring gene RNA binding protein, fox-1 homolog (C. elegans) 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ApoL6 associates with lipid droplets and disrupts Perilipin1-HSL interaction to inhibit lipolysis. Wang Y, et al. Nat Commun, 2024 Jan 2. PMID 38167864, Free PMC Article
  2. miR-10b-5p regulates 3T3-L1 cells differentiation by targeting Apol6. Tan Y, et al. Gene, 2019 Mar 1. PMID 30423386
  3. Maternal exercise intergenerationally drives muscle-based thermogenesis via activation of apelin-AMPK signaling. Son JS, et al. EBioMedicine, 2022 Feb. PMID 35081489, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ApoL6 associates with lipid droplets and disrupts Perilipin1-HSL interaction to inhibit lipolysis.
    Title: ApoL6 associates with lipid droplets and disrupts Perilipin1-HSL interaction to inhibit lipolysis.
  2. High APOL6 expression is associated with obesity and obesity-related cancers.
    Title: miR-10b-5p regulates 3T3-L1 cells differentiation by targeting Apol6.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
apolipoprotein L6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163621.1 → NP_001157093.1  apolipoprotein L6 isoform 2

    See identical proteins and their annotated locations for NP_001157093.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, and uses an alternate splice pattern in the 3' coding region, compared to variant 1. The resulting isoform (2) has a longer and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AI481097, AK144563, AL603843
    Consensus CDS
    CCDS49656.1
    UniProtKB/TrEMBL
    B7ZC55, Q9D6L7
    Related
    ENSMUSP00000118257.2, ENSMUST00000127957.8
    Conserved Domains (1) summary
    pfam05461
    Location:18 → 290
    ApoL; Apolipoprotein L

  2. NM_028010.1 → NP_082286.1  apolipoprotein L6 isoform 1

    See identical proteins and their annotated locations for NP_082286.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
    Source sequence(s)
    AI481775, AK010208, AL603843
    Consensus CDS
    CCDS49655.1
    UniProtKB/TrEMBL
    B7ZC54, Q9D6L7
    Related
    ENSMUSP00000120866.2, ENSMUST00000149569.9
    Conserved Domains (1) summary
    pfam05461
    Location:26 → 290
    ApoL; Apolipoprotein L

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    76929195..76941308
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521421.5 → XP_006521484.1  apolipoprotein L6 isoform X2

    See identical proteins and their annotated locations for XP_006521484.1

    UniProtKB/TrEMBL
    B7ZC54, Q9D6L7
    Conserved Domains (1) summary
    pfam05461
    Location:26 → 290
    ApoL; Apolipoprotein L

  2. XM_006521419.5 → XP_006521482.1  apolipoprotein L6 isoform X1

    See identical proteins and their annotated locations for XP_006521482.1

    UniProtKB/TrEMBL
    B7ZC55, Q9D6L7
    Conserved Domains (1) summary
    pfam05461
    Location:18 → 290
    ApoL; Apolipoprotein L

  3. XM_006521420.5 → XP_006521483.1  apolipoprotein L6 isoform X1

    See identical proteins and their annotated locations for XP_006521483.1

    UniProtKB/TrEMBL
    B7ZC55, Q9D6L7
    Conserved Domains (1) summary
    pfam05461
    Location:18 → 290
    ApoL; Apolipoprotein L
Nucleotide Protein Strain
Heading Accession and Version

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