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Plpp5 phospholipid phosphatase 5 [ Mus musculus (house mouse) ]

Gene ID: 71910, updated on 18-Sep-2024

Summary

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Official Symbol
Plpp5provided by MGI
Official Full Name
phospholipid phosphatase 5provided by MGI
Primary source
MGI:MGI:1919160
See related
Ensembl:ENSMUSG00000031570 AllianceGenome:MGI:1919160
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ppapdc1; Ppapdc1b; 1810019D05Rik; 2310022A04Rik
Summary
Predicted to enable diacylglycerol diphosphate phosphatase activity and phosphatidate phosphatase activity. Predicted to be involved in phospholipid dephosphorylation. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Orthologous to human PLPP5 (phospholipid phosphatase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 43.6), colon adult (RPKM 40.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Plpp5 in Genome Data Viewer
Location:
8 A2; 8 14.17 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (26210052..26214914)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (25720043..25724887)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8232 Neighboring gene STARR-positive B cell enhancer ABC_E2860 Neighboring gene leucine zipper-EF-hand containing transmembrane protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E6630 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:26722454-26722679 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:26728550-26728737 Neighboring gene nuclear receptor binding SET domain protein 3 Neighboring gene predicted gene, 24992 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:26830817-26831000 Neighboring gene DDHD domain containing 2 Neighboring gene predicted gene, 17484 Neighboring gene BCL2-associated athanogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mining the Plasma Cell Transcriptome for Novel Cell Surface Proteins. Trezise S, et al. Int J Mol Sci, 2018 Jul 24. PMID 30042348, Free PMC Article
  2. An Ideal PPAR Response Element Bound to and Activated by PPARα. Tzeng J, et al. PLoS One, 2015. PMID 26241474, Free PMC Article
  3. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
  4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables diacylglycerol diphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables diacylglycerol diphosphate phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidate phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in phospholipid dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipid dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phospholipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phospholipid phosphatase 5
Names
phosphatidate phosphatase PPAPDC1B
phosphatidic acid phosphatase type 2 domain containing 1
phosphatidic acid phosphatase type 2 domain containing 1B
phosphatidic acid phosphatase type 2 domain-containing protein 1B
NP_001280632.1
NP_082276.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293703.1 → NP_001280632.1  phospholipid phosphatase 5 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 3' end compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AA184457, BB857717, BC062173, BE646843
    Consensus CDS
    CCDS80868.1
    UniProtKB/TrEMBL
    Q6P6K4
    Related
    ENSMUSP00000122437.2, ENSMUST00000139836.8
    Conserved Domains (1) summary
    cd03390
    Location:39 → 207
    PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...

  2. NM_028000.1 → NP_082276.1  phospholipid phosphatase 5 isoform 1

    See identical proteins and their annotated locations for NP_082276.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AA184457, CO044265, DV661598
    Consensus CDS
    CCDS40306.1
    UniProtKB/Swiss-Prot
    Q3UMZ3, Q4KL19
    Related
    ENSMUSP00000067035.9, ENSMUST00000068916.16
    Conserved Domains (1) summary
    cd03390
    Location:39 → 227
    PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...

RNA

  1. NR_121642.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction at the 3' end of an exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA184457, BC062173
    Related
    ENSMUST00000124764.8

  2. NR_121643.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses alternate splice junctions at the 5' end of one exon and 3' end of another exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA184457, BC062173
    Related
    ENSMUST00000145678.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    26210052..26214914
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003947335.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UMZ3.1 GenPept UniProtKB/Swiss-Prot:Q3UMZ3

Gene LinkOut

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