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Mad2l2 MAD2 mitotic arrest deficient-like 2 [ Mus musculus (house mouse) ]

Gene ID: 71890, updated on 2-Nov-2024

Summary

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Official Symbol
Mad2l2provided by MGI
Official Full Name
MAD2 mitotic arrest deficient-like 2provided by MGI
Primary source
MGI:MGI:1919140
See related
Ensembl:ENSMUSG00000029003 AllianceGenome:MGI:1919140
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
REV7; MAD2B; repro22; G1-453-4; 2310033C13Rik
Summary
Predicted to enable JUN kinase binding activity and RNA polymerase II-specific DNA-binding transcription factor binding activity. Predicted to be involved in several processes, including regulation of epithelial to mesenchymal transition; regulation of nucleobase-containing compound metabolic process; and regulation of protein metabolic process. Predicted to be located in nucleoplasm and spindle. Predicted to be part of anaphase-promoting complex and zeta DNA polymerase complex. Is expressed in several structures, including brain; ganglia; genitourinary system; hemolymphoid system gland; and intestine. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group V. Orthologous to human MAD2L2 (mitotic arrest deficient 2 like 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis adult (RPKM 68.8), CNS E14 (RPKM 17.7) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Mad2l2 in Genome Data Viewer
Location:
4 E2; 4 78.67 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (148214615..148230161)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (148130158..148145704)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 13201 Neighboring gene STARR-positive B cell enhancer ABC_E6283 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E4727 Neighboring gene STARR-seq mESC enhancer starr_12067 Neighboring gene angiotensin II, type I receptor-associated protein Neighboring gene STARR-seq mESC enhancer starr_12068 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:147472153-147472360 Neighboring gene dorsal inhibitory axon guidance protein Neighboring gene STARR-positive B cell enhancer ABC_E2146 Neighboring gene STARR-positive B cell enhancer ABC_E4728 Neighboring gene microRNA 7022 Neighboring gene F-box protein 6 Neighboring gene STARR-positive B cell enhancer ABC_E3553 Neighboring gene F-box protein 44 Neighboring gene F-box protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Leydig cell hyperplasia in an ENU-induced mutant mouse with germ cell depletion. Khalaj M, et al. J Reprod Dev, 2008 Jun. PMID 18385543
  2. REV7 Monomer Is Unable to Participate in Double Strand Break Repair and Translesion Synthesis but Suppresses Mitotic Errors. Vassel FM, et al. Int J Mol Sci, 2023 Oct 31. PMID 37958783, Free PMC Article
  3. MAD2B Blunts Chronic Unpredictable Stress and Corticosterone Stimulation-Induced Depression-Like Behaviors in Mice. Wang XL, et al. Int J Neuropsychopharmacol, 2023 Feb 14. PMID 36573299, Free PMC Article
  4. Lack of Rev7 function results in development of tubulostromal adenomas in mouse ovary. Abbasi A, et al. Mol Cell Endocrinol, 2015 Sep 5. PMID 26004212
  5. Destabilization of pluripotency in the absence of Mad2l2. Pirouz M, et al. Cell Cycle, 2015. PMID 25928475, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. REV7 Monomer Is Unable to Participate in Double Strand Break Repair and Translesion Synthesis but Suppresses Mitotic Errors.
    Title: REV7 Monomer Is Unable to Participate in Double Strand Break Repair and Translesion Synthesis but Suppresses Mitotic Errors.
  2. MAD2B Blunts Chronic Unpredictable Stress and Corticosterone Stimulation-Induced Depression-Like Behaviors in Mice.
    Title: MAD2B Blunts Chronic Unpredictable Stress and Corticosterone Stimulation-Induced Depression-Like Behaviors in Mice.
  3. MAD2B promotes podocyte injury through regulating Numb-dependent Notch 1 pathway in diabetic nephropathy.
    Title: MAD2B promotes podocyte injury through regulating Numb-dependent Notch 1 pathway in diabetic nephropathy.
  4. Inhibition of MAD2B alleviates venous neointimal formation by suppressing VSMCs proliferation and migration.
    Title: Inhibition of MAD2B alleviates venous neointimal formation by suppressing VSMCs proliferation and migration.
  5. MAD2B contributes to parietal epithelial cell activation and crescentic glomerulonephritis via Skp2.
    Title: MAD2B contributes to parietal epithelial cell activation and crescentic glomerulonephritis via Skp2.
  6. REV7 is required for processing AID initiated DNA lesions in activated B cells.
    Title: REV7 is required for processing AID initiated DNA lesions in activated B cells.
  7. 53BP1 pathway therefore comprises distinct double-strand break repair activities within chromatin and single-stranded DNA compartments, which explains both the immunological differences between 53bp1- and Rev7- deficient mice and the context specificity of the pathway
    Title: 53BP1 cooperation with the REV7-shieldin complex underpins DNA structure-specific NHEJ.
  8. Skp2, a confirmed APC/C-CDH1 substrate and E-cadherin destroyer, was increased in TGF-beta1-treated proximal tubular epithelial cells, which could be blocked by MAD2B depletion.
    Title: MAD2B promotes tubular epithelial-to-mesenchymal transition and renal tubulointerstitial fibrosis via Skp2.
  9. This study demonstrates using super-resolution microscopy that numerous MAD2L2 microfoci are exclusively associated with euchromatin, similar to other factors of the DNA damage response. In the absence of MAD2L2 the amount of heterochromatin demarcated by H3K9me2 was significantly increased.
    Title: MAD2L2 Promotes Open Chromatin in Embryonic Stem Cells and Derepresses the Dppa3 Locus.
  10. Increased gonadotropins caused by the absence of functional oocytes and accumulation of DNA damage in cells caused by the lack of repair function could be responsible for the development and progression of ovarian tumors in the Rev7 mutant mouse.
    Title: Lack of Rev7 function results in development of tubulostromal adenomas in mouse ovary.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables JUN kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables JUN kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables RNA polymerase II-specific DNA-binding transcription factor binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response, signal transduction resulting in transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA damage response, signal transduction resulting in transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in actin filament organization IEA
Inferred from Electronic Annotation
more info
  
involved_in actin filament organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair ISO
Inferred from Sequence Orthology
more info
  
involved_in error-prone translesion synthesis IEA
Inferred from Electronic Annotation
more info
  
involved_in error-prone translesion synthesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell-cell adhesion mediated by cadherin IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell-cell adhesion mediated by cadherin ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of epithelial to mesenchymal transition IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by competitive promoter binding IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by competitive promoter binding ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of double-strand break repair via nonhomologous end joining ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of double-strand break repair via nonhomologous end joining NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of extracellular matrix assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of isotype switching IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of isotype switching ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of peptidyl-serine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell growth IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in somatic diversification of immunoglobulins involved in immune response NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in telomere maintenance in response to DNA damage NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of anaphase-promoting complex IEA
Inferred from Electronic Annotation
more info
  
part_of anaphase-promoting complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromatin NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in site of double-strand break NAS
Non-traceable Author Statement
more info
 PubMed 
located_in spindle ISO
Inferred from Sequence Orthology
more info
  
located_in spindle ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of zeta DNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of zeta DNA polymerase complex ISO
Inferred from Sequence Orthology
more info
  
part_of zeta DNA polymerase complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
mitotic spindle assembly checkpoint protein MAD2B
Names
MAD2-like protein 2
mitotic arrest deficient 2-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305420.1 → NP_001292349.1  mitotic spindle assembly checkpoint protein MAD2B

    See identical proteins and their annotated locations for NP_001292349.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK009587, AL606929, CO043741
    Consensus CDS
    CCDS18932.1
    UniProtKB/Swiss-Prot
    Q3TMY6, Q91VP1, Q9D752
    UniProtKB/TrEMBL
    A2A7G6
    Related
    ENSMUSP00000081146.3, ENSMUST00000084129.9
    Conserved Domains (1) summary
    pfam02301
    Location:18 → 103
    HORMA; HORMA domain

  2. NM_027985.3 → NP_082261.2  mitotic spindle assembly checkpoint protein MAD2B

    See identical proteins and their annotated locations for NP_082261.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK009587, AK150216, CO043741
    Consensus CDS
    CCDS18932.1
    UniProtKB/Swiss-Prot
    Q3TMY6, Q91VP1, Q9D752
    UniProtKB/TrEMBL
    A2A7G6
    Related
    ENSMUSP00000030860.3, ENSMUST00000030860.9
    Conserved Domains (1) summary
    pfam02301
    Location:18 → 103
    HORMA; HORMA domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    148214615..148230161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253789.1 → XP_030109649.1  mitotic spindle assembly checkpoint protein MAD2B isoform X1

    UniProtKB/Swiss-Prot
    Q3TMY6, Q91VP1, Q9D752
    UniProtKB/TrEMBL
    A2A7G6
    Conserved Domains (1) summary
    pfam02301
    Location:18 → 103
    HORMA; HORMA domain

  2. XM_006539187.3 → XP_006539250.1  mitotic spindle assembly checkpoint protein MAD2B isoform X1

    See identical proteins and their annotated locations for XP_006539250.1

    UniProtKB/Swiss-Prot
    Q3TMY6, Q91VP1, Q9D752
    UniProtKB/TrEMBL
    A2A7G6
    Conserved Domains (1) summary
    pfam02301
    Location:18 → 103
    HORMA; HORMA domain

  3. XM_030253798.2 → XP_030109658.1  mitotic spindle assembly checkpoint protein MAD2B isoform X3

    UniProtKB/TrEMBL
    A2A7G6, A2A7G7
    Conserved Domains (1) summary
    pfam02301
    Location:18 → 100
    HORMA; HORMA domain

  4. XM_006539183.3 → XP_006539246.1  mitotic spindle assembly checkpoint protein MAD2B isoform X1

    See identical proteins and their annotated locations for XP_006539246.1

    UniProtKB/Swiss-Prot
    Q3TMY6, Q91VP1, Q9D752
    UniProtKB/TrEMBL
    A2A7G6
    Conserved Domains (1) summary
    pfam02301
    Location:18 → 103
    HORMA; HORMA domain

  5. XM_030253794.2 → XP_030109654.1  mitotic spindle assembly checkpoint protein MAD2B isoform X2

    UniProtKB/TrEMBL
    A2A7G6
    Conserved Domains (1) summary
    pfam02301
    Location:18 → 100
    HORMA; HORMA domain

  6. XM_006539186.3 → XP_006539249.1  mitotic spindle assembly checkpoint protein MAD2B isoform X1

    See identical proteins and their annotated locations for XP_006539249.1

    UniProtKB/Swiss-Prot
    Q3TMY6, Q91VP1, Q9D752
    UniProtKB/TrEMBL
    A2A7G6
    Conserved Domains (1) summary
    pfam02301
    Location:18 → 103
    HORMA; HORMA domain

  7. XM_030253797.2 → XP_030109657.1  mitotic spindle assembly checkpoint protein MAD2B isoform X3

    UniProtKB/TrEMBL
    A2A7G6, A2A7G7
    Conserved Domains (1) summary
    pfam02301
    Location:18 → 100
    HORMA; HORMA domain

  8. XM_030253791.1 → XP_030109651.1  mitotic spindle assembly checkpoint protein MAD2B isoform X2

    UniProtKB/TrEMBL
    A2A7G6
    Conserved Domains (1) summary
    pfam02301
    Location:18 → 100
    HORMA; HORMA domain

  9. XM_030253788.2 → XP_030109648.1  mitotic spindle assembly checkpoint protein MAD2B isoform X1

    UniProtKB/Swiss-Prot
    Q3TMY6, Q91VP1, Q9D752
    UniProtKB/TrEMBL
    A2A7G6
    Conserved Domains (1) summary
    pfam02301
    Location:18 → 103
    HORMA; HORMA domain

  10. XM_006539189.4 → XP_006539252.1  mitotic spindle assembly checkpoint protein MAD2B isoform X3

    See identical proteins and their annotated locations for XP_006539252.1

    UniProtKB/TrEMBL
    A2A7G6, A2A7G7
    Conserved Domains (1) summary
    pfam02301
    Location:18 → 100
    HORMA; HORMA domain

  11. XM_030253795.2 → XP_030109655.1  mitotic spindle assembly checkpoint protein MAD2B isoform X3

    UniProtKB/TrEMBL
    A2A7G6, A2A7G7
    Conserved Domains (1) summary
    pfam02301
    Location:18 → 100
    HORMA; HORMA domain

  12. XM_030253792.2 → XP_030109652.1  mitotic spindle assembly checkpoint protein MAD2B isoform X2

    UniProtKB/TrEMBL
    A2A7G6
    Conserved Domains (1) summary
    pfam02301
    Location:18 → 100
    HORMA; HORMA domain

  13. XM_030253799.2 → XP_030109659.1  mitotic spindle assembly checkpoint protein MAD2B isoform X3

    UniProtKB/TrEMBL
    A2A7G6, A2A7G7
    Related
    ENSMUSP00000101332.2, ENSMUST00000105707.2
    Conserved Domains (1) summary
    pfam02301
    Location:18 → 100
    HORMA; HORMA domain

  14. XM_030253796.1 → XP_030109656.1  mitotic spindle assembly checkpoint protein MAD2B isoform X3

    UniProtKB/TrEMBL
    A2A7G6, A2A7G7
    Conserved Domains (1) summary
    pfam02301
    Location:18 → 100
    HORMA; HORMA domain

  15. XM_030253793.2 → XP_030109653.1  mitotic spindle assembly checkpoint protein MAD2B isoform X2

    UniProtKB/TrEMBL
    A2A7G6
    Conserved Domains (1) summary
    pfam02301
    Location:18 → 100
    HORMA; HORMA domain

  16. XM_006539188.3 → XP_006539251.1  mitotic spindle assembly checkpoint protein MAD2B isoform X2

    See identical proteins and their annotated locations for XP_006539251.1

    UniProtKB/TrEMBL
    A2A7G6
    Conserved Domains (1) summary
    pfam02301
    Location:18 → 100
    HORMA; HORMA domain

  17. XM_030253790.2 → XP_030109650.1  mitotic spindle assembly checkpoint protein MAD2B isoform X1

    UniProtKB/Swiss-Prot
    Q3TMY6, Q91VP1, Q9D752
    UniProtKB/TrEMBL
    A2A7G6
    Related
    ENSMUSP00000122774.2, ENSMUST00000132698.8
    Conserved Domains (1) summary
    pfam02301
    Location:18 → 103
    HORMA; HORMA domain

RNA

  1. XR_004941965.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D752.2 GenPept UniProtKB/Swiss-Prot:Q9D752

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