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Coq2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase [ Mus musculus (house mouse) ]

Gene ID: 71883, updated on 2-Nov-2024

Summary

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Official Symbol
Coq2provided by MGI
Official Full Name
coenzyme Q2 4-hydroxybenzoate polyprenyltransferaseprovided by MGI
Primary source
MGI:MGI:1919133
See related
Ensembl:ENSMUSG00000029319 AllianceGenome:MGI:1919133
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PHB:PPT; 2310002F18Rik
Summary
Predicted to enable 4-hydroxybenzoate polyprenyltransferase activity. Predicted to be involved in glycerol metabolic process and ubiquinone biosynthetic process. Located in mitochondrion. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and integumental system. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 1. Orthologous to human COQ2 (coenzyme Q2, polyprenyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 58.8), ovary adult (RPKM 49.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Coq2 in Genome Data Viewer
Location:
5 E4; 5 48.5 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (100802589..100822154, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (100654723..100674288, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene COP9 signalosome subunit 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:100998499-100998608 Neighboring gene placenta-specific 8 Neighboring gene STARR-positive B cell enhancer ABC_E11295 Neighboring gene STARR-positive B cell enhancer ABC_E11296 Neighboring gene STARR-positive B cell enhancer mm9_chr5:101027025-101027325 Neighboring gene STARR-positive B cell enhancer ABC_E9256 Neighboring gene STARR-positive B cell enhancer ABC_E8823 Neighboring gene STARR-seq mESC enhancer starr_13729 Neighboring gene heparanase Neighboring gene predicted gene, 36619

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. 4-Hydroxybenzoic acid rescues multisystemic disease and perinatal lethality in a mouse model of mitochondrial disease. Corral-Sarasa J, et al. Cell Rep, 2024 May 28. PMID 38697100
  2. Calorie restriction modifies ubiquinone and COQ transcript levels in mouse tissues. Parrado-Fernández C, et al. Free Radic Biol Med, 2011 Jun 15. PMID 21447381, Free PMC Article
  3. Global analysis of gene expression in the developing brain of Gtf2ird1 knockout mice. O'Leary J, et al. PLoS One, 2011. PMID 21909369, Free PMC Article
  4. The SRCAP chromatin remodeling complex promotes oxidative metabolism during prenatal heart development. Xu M, et al. Development, 2021 Apr 15. PMID 33913477
  5. Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease. Tkatchenko TV, et al. Physiol Genomics, 2009 Nov 6. PMID 19723774, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Calorie restriction modifies ubiquinone and COQ transcript levels in mouse tissues
    Title: Calorie restriction modifies ubiquinone and COQ transcript levels in mouse tissues.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC91278

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 4-hydroxybenzoate polyprenyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 4-hydroxybenzoate polyprenyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables 4-hydroxybenzoate polyprenyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables prenyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in glycerol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in isoprenoid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquinone biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquinone biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ubiquinone biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquinone biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquinone biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
4-hydroxybenzoate polyprenyltransferase, mitochondrial
Names
4-HB polyprenyltransferase
PHB:polyprenyltransferase
coenzyme Q2 homolog, prenyltransferase
para-hydroxybenzoate--polyprenyltransferase, mitochondrial
NP_082254.2
XP_036021392.1
XP_036021393.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027978.2 → NP_082254.2  4-hydroxybenzoate polyprenyltransferase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_082254.2

    Status: VALIDATED

    Source sequence(s)
    AK009092, CK626929
    Consensus CDS
    CCDS19465.1
    UniProtKB/Swiss-Prot
    E9QPH1, Q66JT7, Q9D7M9
    Related
    ENSMUSP00000031262.8, ENSMUST00000031262.9
    Conserved Domains (1) summary
    cl00337
    Location:68 → 352
    PT_UbiA; UbiA family of prenyltransferases (PTases)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    100802589..100822154 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165499.1 → XP_036021392.1  4-hydroxybenzoate polyprenyltransferase, mitochondrial isoform X1

    Conserved Domains (1) summary
    cl00337
    Location:97 → 265
    PT_UbiA; UbiA family of prenyltransferases (PTases)

  2. XM_036165500.1 → XP_036021393.1  4-hydroxybenzoate polyprenyltransferase, mitochondrial isoform X2

    Conserved Domains (1) summary
    cl00337
    Location:10 → 222
    PT_UbiA; UbiA family of prenyltransferases (PTases)

RNA

  1. XR_389292.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66JT7.2 GenPept UniProtKB/Swiss-Prot:Q66JT7

Gene LinkOut

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