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Apmap adipocyte plasma membrane associated protein [ Mus musculus (house mouse) ]

Gene ID: 71881, updated on 2-Nov-2024

Summary

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Official Symbol
Apmapprovided by MGI
Official Full Name
adipocyte plasma membrane associated proteinprovided by MGI
Primary source
MGI:MGI:1919131
See related
Ensembl:ENSMUSG00000033096 AllianceGenome:MGI:1919131
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310001A20Rik
Summary
Predicted to enable arylesterase activity. Predicted to be involved in biosynthetic process. Predicted to be located in cell surface and membrane. Is expressed in olfactory epithelium. Orthologous to human APMAP (adipocyte plasma membrane associated protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in kidney adult (RPKM 26.0), subcutaneous fat pad adult (RPKM 25.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Apmap in Genome Data Viewer
Location:
2 G3; 2 74.68 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (150425000..150450487, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (150583080..150608567, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ankyrin and armadillo repeat containing pseudogene Neighboring gene STARR-seq mESC enhancer starr_06007 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:150404413-150404596 Neighboring gene cystatin F (leukocystatin) Neighboring gene STARR-positive B cell enhancer ABC_E2647 Neighboring gene predicted gene, 52532 Neighboring gene acyl-CoA synthetase short-chain family member 1 Neighboring gene STARR-seq mESC enhancer starr_06012 Neighboring gene RIKEN cDNA E130215H24 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. APMAP interacts with lysyl oxidase-like proteins, and disruption of Apmap leads to beneficial visceral adipose tissue expansion. Pessentheiner AR, et al. FASEB J, 2017 Sep. PMID 28559441, Free PMC Article
  2. Identification of a novel integral plasma membrane protein induced during adipocyte differentiation. Albrektsen T, et al. Biochem J, 2001 Oct 15. PMID 11583587, Free PMC Article
  3. Reconstruction of gene association network reveals a transmembrane protein required for adipogenesis and targeted by PPARγ. Bogner-Strauss JG, et al. Cell Mol Life Sci, 2010 Dec. PMID 20552250, Free PMC Article
  4. The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer's disease. Gerber H, et al. Acta Neuropathol Commun, 2019 Jan 31. PMID 30704515, Free PMC Article
  5. Pancreatic islet and progenitor cell surface markers with cell sorting potential. Hald J, et al. Diabetologia, 2012 Jan. PMID 21947380

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data suggest that APMAP is a novel regulator of extracellular matrix components, and establish that APMAP is a potential target to mitigate obesity-associated insulin resistance.
    Title: APMAP interacts with lysyl oxidase-like proteins, and disruption of Apmap leads to beneficial visceral adipose tissue expansion.
  2. Data demonstrate that APMAP contains a functional PPARgamma binding site, and that APMAP translocates from the endoplasmatic reticulum to the plasma membrane during adipocyte differentiation
    Title: Reconstruction of gene association network reveals a transmembrane protein required for adipogenesis and targeted by PPARγ.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables arylesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arylesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables arylesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables strictosidine synthase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
adipocyte plasma membrane-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356491.1 → NP_001343420.1  adipocyte plasma membrane-associated protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL845174
    Conserved Domains (2) summary
    COG3386
    Location:1 → 243
    YvrE; Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]
    cl22863
    Location:124 → 211
    Str_synth; Strictosidine synthase

  2. NM_001356492.1 → NP_001343421.1  adipocyte plasma membrane-associated protein isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and uses an alternate splice junction compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL845174
    Conserved Domains (1) summary
    cl22863
    Location:5 → 92
    Str_synth; Strictosidine synthase

  3. NM_027977.3 → NP_082253.1  adipocyte plasma membrane-associated protein isoform 1

    See identical proteins and their annotated locations for NP_082253.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK009057, BY230335
    Consensus CDS
    CCDS16858.1
    UniProtKB/Swiss-Prot
    A2AQX3, Q3U4F4, Q9D7N9
    Related
    ENSMUSP00000040840.7, ENSMUST00000046399.7
    Conserved Domains (4) summary
    COG3386
    Location:72 → 319
    YvrE; Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]
    cd05819
    Location:101 → 136
    NHL; NHL repeat [structural motif]
    cl18310
    Location:95 → 283
    NHL; NHL repeat unit of beta-propeller proteins
    cl22863
    Location:200 → 287
    Str_synth; Strictosidine synthase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    150425000..150450487 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500198.4 → XP_006500261.1  adipocyte plasma membrane-associated protein isoform X1

    Conserved Domains (2) summary
    COG3386
    Location:33 → 280
    YvrE; Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]
    cl22863
    Location:161 → 248
    Str_synth; Strictosidine synthase

  2. XM_036162580.1 → XP_036018473.1  adipocyte plasma membrane-associated protein isoform X2

    Conserved Domains (1) summary
    cl22863
    Location:5 → 92
    Str_synth; Strictosidine synthase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D7N9.1 GenPept UniProtKB/Swiss-Prot:Q9D7N9

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