Cenpu centromere protein U [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cenpuprovided by MGI
Official Full Name: centromere protein Uprovided by MGI
Primary source: MGI:MGI:1919126
See related: Ensembl:ENSMUSG00000031629 AllianceGenome:MGI:1919126
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mlf1ip; 1700029A22Rik
Summary: Acts upstream of or within chordate embryonic development. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; gonad; hemolymphoid system; and sensory organ. Orthologous to human CENPU (centromere protein U). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in testis adult (RPKM 4.2), liver E14 (RPKM 3.4) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B1.1; 8 26.38 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (47005054..47033603)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (46552019..46580568)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CENP-50 is required for papilloma development in the two-stage skin carcinogenesis model.
Title: CENP-50 is required for papilloma development in the two-stage skin carcinogenesis model.
MLF1IP transgenic mice developed polycythemia vera (PV)-like symptoms based on the analysis of hematological features, suggesting that MLF1IP is partially involved in the pathogenesis of PV.
Title: MLF1IP promotes normal erythroid proliferation and is involved in the pathogenesis of polycythemia vera.
MLF1-IP expression at about 50% of its normal level is sufficient to sustain mice life and the development of their immune system without apparent abnormalities.
Title: Investigation of tissue-specific expression and functions of MLF1-IP during development and in the immune system.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within chordate embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromosome segregation	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in centriolar satellite	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of inner kinetochore	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: centromere protein U

Names: CENP-U; MLF1-interacting protein; myeloid leukemia factor 1 interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001368403.1 → NP_001355332.1 centromere protein U isoform 2

Status: VALIDATED

Source sequence(s)

AC119267

UniProtKB/TrEMBL

Q149H7

Conserved Domains (2) summary

pfam13097
Location:139 → 307

CENP-U; CENP-A nucleosome associated complex (NAC) subunit

pfam01496
Location:242 → 384

V_ATPase_I; V-type ATPase 116kDa subunit family
NM_027973.4 → NP_082249.1 centromere protein U isoform 1

See identical proteins and their annotated locations for NP_082249.1

Status: VALIDATED

Source sequence(s)

AC119267

Consensus CDS

CCDS22292.1

UniProtKB/Swiss-Prot

Q6UNA2, Q8C4M7, Q9D9U1

UniProtKB/TrEMBL

Q149H7

Related

ENSMUSP00000034045.8, ENSMUST00000034045.15

Conserved Domains (1) summary

pfam13097
Location:144 → 312

CENP-U; CENP-A nucleosome associated complex (NAC) subunit

RNA

NR_160797.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC119267

Related

ENSMUST00000135432.8
NR_160798.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC119267