U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Aox4 aldehyde oxidase 4 [ Mus musculus (house mouse) ]

Gene ID: 71872, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
Aox4provided by MGI
Official Full Name
aldehyde oxidase 4provided by MGI
Primary source
MGI:MGI:1919122
See related
Ensembl:ENSMUSG00000038242 AllianceGenome:MGI:1919122
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Aoh2; 2310003G12Rik
Summary
Predicted to enable aldehyde oxidase activity; electron transfer activity; and molybdenum ion binding activity. Predicted to be located in cytoplasm. Is expressed in anterior naris and external naris. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in stomach adult (RPKM 1.8), testis adult (RPKM 0.4) and 10 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Aox4 in Genome Data Viewer
Location:
1 C1.3; 1 28.97 cM
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (58249556..58307759)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (58210397..58268600)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_01005 Neighboring gene predicted gene, 39643 Neighboring gene aldehyde oxidase 3 Neighboring gene predicted gene, 24548 Neighboring gene predicted gene 15759 Neighboring gene aldehyde oxidase 2 Neighboring gene ribosomal protein S27 pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Mouse aldehyde-oxidase-4 controls diurnal rhythms, fat deposition and locomotor activity. Terao M, et al. Sci Rep, 2016 Jul 26. PMID 27456060, Free PMC Article
  2. Role of the molybdoflavoenzyme aldehyde oxidase homolog 2 in the biosynthesis of retinoic acid: generation and characterization of a knockout mouse. Terao M, et al. Mol Cell Biol, 2009 Jan. PMID 18981221, Free PMC Article
  3. Cloning of the cDNAs coding for two novel molybdo-flavoproteins showing high similarity with aldehyde oxidase and xanthine oxidoreductase. Terao M, et al. J Biol Chem, 2000 Sep 29. PMID 10893244
  4. Insights into the structural determinants of substrate specificity and activity in mouse aldehyde oxidases. Cerqueira NM, et al. J Biol Inorg Chem, 2015 Mar. PMID 25287365
  5. The aldehyde oxidase gene cluster in mice and rats. Aldehyde oxidase homologue 3, a novel member of the molybdo-flavoenzyme family with selective expression in the olfactory mucosa. Kurosaki M, et al. J Biol Chem, 2004 Nov 26. PMID 15383531

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deletion of the Aox4 gene causes perturbations in diurnal rhythms, fat deposition and locomotor activity.
    Title: Mouse aldehyde-oxidase-4 controls diurnal rhythms, fat deposition and locomotor activity.
  2. Although mAOX2 and mAOX3 are very similar to each other, we propose the following pairs of overlapping substrate specificities: mAOX2/mAOX4 and mAOX3/mAXO1.
    Title: Insights into the structural determinants of substrate specificity and activity in mouse aldehyde oxidases.
  3. data indicate a significant role of AOH2 in the local synthesis and biodisposition of endogenous retinoids in the Harderian gland and skin
    Title: Role of the molybdoflavoenzyme aldehyde oxidase homolog 2 in the biosynthesis of retinoic acid: generation and characterization of a knockout mouse.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC144189, MGC144190

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables FAD binding IEA
Inferred from Electronic Annotation
more info
  
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables aldehyde oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aldehyde oxidase activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables aldehyde oxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables electron transfer activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables flavin adenine dinucleotide binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables iron ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables molybdenum ion binding ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables molybdopterin cofactor binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in xenobiotic metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
aldehyde oxidase 4
Names
aldehyde oxidase homolog 2
aldehyde oxidase structural homolog 2
azaheterocycle hydroxylase 4
retinal oxidase
NP_076120.2
XP_006496350.1
XP_036009585.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023631.2 → NP_076120.2  aldehyde oxidase 4

    See identical proteins and their annotated locations for NP_076120.2

    Status: VALIDATED

    Source sequence(s)
    AC025116, AI414378, AK158427
    Consensus CDS
    CCDS14970.1
    UniProtKB/Swiss-Prot
    Q3TYQ9, Q8VI17
    UniProtKB/TrEMBL
    Q148T8
    Related
    ENSMUSP00000048929.6, ENSMUST00000040442.6
    Conserved Domains (7) summary
    TIGR02969
    Location:9 → 1335
    mam_aldehyde_ox; aldehyde oxidase
    smart01008
    Location:596 → 699
    Ald_Xan_dh_C; Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
    pfam00111
    Location:12 → 82
    Fer2; 2Fe-2S iron-sulfur cluster binding domain
    pfam00941
    Location:240 → 420
    FAD_binding_5; FAD binding domain in molybdopterin dehydrogenase
    pfam01799
    Location:91 → 162
    Fer2_2; [2Fe-2S] binding domain
    pfam02738
    Location:713 → 1243
    Ald_Xan_dh_C2; Molybdopterin-binding domain of aldehyde dehydrogenase
    pfam03450
    Location:431 → 532
    CO_deh_flav_C; CO dehydrogenase flavoprotein C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    58249556..58307759
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153692.1 → XP_036009585.1  aldehyde oxidase 4 isoform X1

    UniProtKB/TrEMBL
    Q148T8
    Conserved Domains (1) summary
    TIGR02969
    Location:2 → 1160
    mam_aldehyde_ox; aldehyde oxidase

  2. XM_006496287.2 → XP_006496350.1  aldehyde oxidase 4 isoform X2

    UniProtKB/TrEMBL
    Q148T8
    Conserved Domains (1) summary
    TIGR02969
    Location:9 → 1119
    mam_aldehyde_ox; aldehyde oxidase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TYQ9.1 GenPept UniProtKB/Swiss-Prot:Q3TYQ9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools