PLCB1 phospholipase C beta 1 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: PLCB1provided by VGNC
Official Full Name: phospholipase C beta 1provided by VGNC
Primary source: VGNC:VGNC:76033
See related: Ensembl:ENSMMUG00000004313
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	10	NC_041763.1 (57618867..58373796, complement)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	10	NC_027902.1 (41049864..41850611)

Chromosome 10 - NC_041763.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

WI-17062 (e-PCR)
- UniSTS:73487

Z94580 (e-PCR)
- UniSTS:20767

D20S594E (e-PCR)
- UniSTS:37163

PLCB1__1209 (e-PCR)
- UniSTS:277588

PLCB1__v332 (e-PCR)
- UniSTS:277588

Plcb1 (e-PCR), detects polymorphism
- UniSTS:144219

SHGC-82613 (e-PCR)
- UniSTS:95606

RH104103 (e-PCR)
- UniSTS:98428

AB048884 (e-PCR)
- UniSTS:480132

Z94679 (e-PCR)
- UniSTS:66709

RH48470 (e-PCR)
- UniSTS:49561

A007B46 (e-PCR)
- UniSTS:3741

D20S580E (e-PCR)
- UniSTS:7842

RH92761 (e-PCR)
- UniSTS:88996

AL021622 (e-PCR)
- UniSTS:683

Z94569 (e-PCR)
- UniSTS:33200

G18109 (e-PCR)
- UniSTS:82610

STS-AA009431 (e-PCR)
- UniSTS:10198

D20S819 (e-PCR)
- UniSTS:59352

D20S177 (e-PCR), detects polymorphism
- UniSTS:12784

D20S177 (e-PCR), detects polymorphism
- UniSTS:12785

RH123804 (e-PCR)
- UniSTS:136181

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables calmodulin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables phosphatidylinositol phospholipase C activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in memory	IEA Inferred from Electronic Annotation more info	PubMed
involved_in phosphatidylinositol-mediated signaling	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in nuclear speck	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Names: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1; phospholipase C, beta 1 (phosphoinositide-specific)

NP_001244796.1

EC 3.1.4.11

XP_015004859.1

EC 3.1.4.11

XP_028683273.1

EC 3.1.4.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001257867.1 → NP_001244796.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

See identical proteins and their annotated locations for NP_001244796.1

Status: PROVISIONAL

Source sequence(s)

JU333613

UniProtKB/TrEMBL

F6ZKK2, F6ZKL2

Related

ENSMMUP00000005767.2, ENSMMUT00000006126.4

Conserved Domains (7) summary

cd00275
Location:677 → 796

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08591
Location:316 → 643

PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta

PLN02952
Location:216 → 784

PLN02952; phosphoinositide phospholipase C

cd13361
Location:22 → 148

PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain

pfam06631
Location:903 → 939

DUF1154; Protein of unknown function (DUF1154)

pfam08703
Location:1003 → 1172

PLC-beta_C; PLC-beta C terminal

pfam09279
Location:224 → 314

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041763.1 Reference Mmul_10 Primary Assembly

Range

57618867..58373796 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015149373.2 → XP_015004859.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1

UniProtKB/TrEMBL

F6R8R8, F6ZKK2, H9FRV8

Related

ENSMMUP00000037506.3, ENSMMUT00000044488.3

Conserved Domains (7) summary

cd00275
Location:677 → 796

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08591
Location:316 → 643

PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta

PLN02952
Location:216 → 784

PLN02952; phosphoinositide phospholipase C

cd13361
Location:22 → 148

PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain

pfam06631
Location:903 → 939

DUF1154; Protein of unknown function (DUF1154)

pfam08703
Location:1003 → 1141

PLC-beta_C; PLC-beta C terminal

pfam09279
Location:224 → 314

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
XM_028827440.1 → XP_028683273.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X2

UniProtKB/TrEMBL

F6ZKK2

Related

ENSMMUP00000005768.4, ENSMMUT00000006127.4

Conserved Domains (6) summary

cd00275
Location:576 → 695

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08591
Location:215 → 542

PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta

pfam08703
Location:902 → 1075

PLC-beta_C; PLC-beta C terminal

cd16208
Location:52 → 202

EFh_PI-PLCbeta1; EF-hand motif found in phosphoinositide phospholipase C beta 1 (PI-PLC-beta1)

pfam06631
Location:802 → 838

DUF1154; Protein of unknown function (DUF1154)

cl17171
Location:1 → 47

PH-like; Pleckstrin homology-like domain