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Ddi1 DNA-damage inducible 1 [ Mus musculus (house mouse) ]

Gene ID: 71829, updated on 9-Nov-2024

Summary

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Official Symbol
Ddi1provided by MGI
Official Full Name
DNA-damage inducible 1provided by MGI
Primary source
MGI:MGI:1919079
See related
Ensembl:ENSMUSG00000047619 AllianceGenome:MGI:1919079
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700011N24Rik
Summary
Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in several processes, including cellular response to hydroxyurea; regulation of DNA stability; and regulation of protein stability. Is expressed in brain and future brain. Orthologous to human DDI1 (DNA damage inducible 1 homolog 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human all
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Genomic context

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See Ddi1 in Genome Data Viewer
Location:
9 A1; 9 2.46 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (6265028..6266547, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (6265028..6266547, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_23188 Neighboring gene heat shock protein 90 alpha (cytosolic), class B member 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_23189 Neighboring gene STARR-seq mESC enhancer starr_23190 Neighboring gene non-POU-domain-containing, octamer binding protein pseudogene Neighboring gene platelet-derived growth factor, D polypeptide Neighboring gene STARR-seq mESC enhancer starr_23191 Neighboring gene STARR-seq mESC enhancer starr_23193 Neighboring gene STARR-seq mESC enhancer starr_23194 Neighboring gene STARR-seq mESC enhancer starr_23195 Neighboring gene predicted gene, 21089 Neighboring gene predicted gene, 23097

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Normal spermatogenesis and fertility in Ddi1 (DNA damage inducible 1) mutant mice. Yousaf A, et al. Reprod Biol, 2020 Dec. PMID 33092996
  2. Quantitative proteomics reveals neuronal ubiquitination of Rngo/Ddi1 and several proteasomal subunits by Ube3a, accounting for the complexity of Angelman syndrome. Ramirez J, et al. Hum Mol Genet, 2018 Jun 1. PMID 29788202
  3. DDI2 protease controls embryonic development and inflammation via TCF11/NRF1. Nedomova M, et al. iScience, 2024 Oct 18. PMID 39328932, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Normal spermatogenesis and fertility in Ddi1 (DNA damage inducible 1) mutant mice.
    Title: Normal spermatogenesis and fertility in Ddi1 (DNA damage inducible 1) mutant mice.
  2. The novel observation that DDI1 is expressed in the developing mice brain, with a significant peak at E16.5, strongly suggests that DDI1 has biological functions not yet described that could be of relevance for Angelman syndrome clinical research.
    Title: Quantitative proteomics reveals neuronal ubiquitination of Rngo/Ddi1 and several proteasomal subunits by Ube3a, accounting for the complexity of Angelman syndrome.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to hydroxyurea ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to hydroxyurea ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasomal protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of DNA stability ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA stability ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein stability ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
protein DDI1 homolog 1
Names
DDI1, DNA-damage inducible 1, homolog 1
NP_082218.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027942.1 → NP_082218.1  protein DDI1 homolog 1

    See identical proteins and their annotated locations for NP_082218.1

    Status: PROVISIONAL

    Source sequence(s)
    AK005882
    Consensus CDS
    CCDS40527.1
    UniProtKB/Swiss-Prot
    Q9DAF3
    Related
    ENSMUSP00000053223.5, ENSMUST00000051706.6
    Conserved Domains (2) summary
    cd05479
    Location:235 → 357
    RP_DDI; retropepsin-like domain of DNA damage inducible protein
    cd01796
    Location:1 → 76
    Ubl_Ddi1_like; ubiquitin-like (Ubl) domain found in the eukaryotic Ddi1 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    6265028..6266547 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DAF3.1 GenPept UniProtKB/Swiss-Prot:Q9DAF3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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