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Cpn2 carboxypeptidase N, polypeptide 2 [ Mus musculus (house mouse) ]

Gene ID: 71756, updated on 2-Nov-2024

Summary

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Official Symbol
Cpn2provided by MGI
Official Full Name
carboxypeptidase N, polypeptide 2provided by MGI
Primary source
MGI:MGI:1919006
See related
Ensembl:ENSMUSG00000023176 AllianceGenome:MGI:1919006
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1300018K11Rik
Summary
Predicted to be involved in inorganic cation transmembrane transport; metal ion transport; and monoatomic cation transmembrane transport. Located in collagen-containing extracellular matrix. Orthologous to human CPN2 (carboxypeptidase N subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver adult (RPKM 111.2) and liver E18 (RPKM 15.0) See more
Orthologs
human all
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Genomic context

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See Cpn2 in Genome Data Viewer
Location:
16 B2; 16 21.22 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (30075196..30086350, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (30256378..30267532, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26562 Neighboring gene RIKEN cDNA 1700025H01 gene Neighboring gene STARR-seq mESC enhancer starr_40571 Neighboring gene STARR-seq mESC enhancer starr_40572 Neighboring gene STARR-positive B cell enhancer ABC_E5535 Neighboring gene predicted gene, 33330 Neighboring gene STARR-seq mESC enhancer starr_40574 Neighboring gene leucine rich repeat containing 15 Neighboring gene glycoprotein 5 platelet

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides. Bernhard OK, et al. J Proteome Res, 2007 Mar. PMID 17330941
  2. Proteome-wide characterization of N-glycosylation events by diagonal chromatography. Ghesquière B, et al. J Proteome Res, 2006 Sep. PMID 16944957
  3. The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Naba A, et al. Mol Cell Proteomics, 2012 Apr. PMID 22159717, Free PMC Article
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in inorganic cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in metal ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
carboxypeptidase N subunit 2
Names
carboxypeptidase N 83 kDa chain
carboxypeptidase N large subunit
carboxypeptidase N regulatory subunit
carboxypeptidase N, polypeptide 2 homolog
NP_082180.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027904.3 → NP_082180.2  carboxypeptidase N subunit 2 precursor

    See identical proteins and their annotated locations for NP_082180.2

    Status: VALIDATED

    Source sequence(s)
    AC163355, AK005049
    Consensus CDS
    CCDS49819.1
    UniProtKB/Swiss-Prot
    B2RR89, Q8R113, Q9DBB9
    Related
    ENSMUSP00000069318.8, ENSMUST00000064856.9
    Conserved Domains (5) summary
    smart00013
    Location:21 → 52
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:395 → 436
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:149 → 374
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:123 → 146
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:313 → 373
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    30075196..30086350 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DBB9.2 GenPept UniProtKB/Swiss-Prot:Q9DBB9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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