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Slc41a3 solute carrier family 41, member 3 [ Mus musculus (house mouse) ]

Gene ID: 71699, updated on 28-Oct-2024

Summary

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Official Symbol
Slc41a3provided by MGI
Official Full Name
solute carrier family 41, member 3provided by MGI
Primary source
MGI:MGI:1918949
See related
Ensembl:ENSMUSG00000030089 AllianceGenome:MGI:1918949
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SLC41A1-L2; 1010001P06Rik
Summary
Predicted to enable magnesium:sodium antiporter activity. Predicted to be involved in mitochondrial magnesium ion transmembrane transport. Predicted to be located in mitochondrial inner membrane. Predicted to be active in plasma membrane. Is expressed in alimentary system; eye; hemolymphoid system; liver; and nervous system. Orthologous to human SLC41A3 (solute carrier family 41 member 3). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in heart adult (RPKM 26.9), testis adult (RPKM 24.1) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Slc41a3 in Genome Data Viewer
Location:
6 D1; 6 40.16 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (90579043..90623394)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (90604730..90646412)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene Kruppel-like transcription factor 15 Neighboring gene STARR-seq mESC enhancer starr_16625 Neighboring gene STARR-seq mESC enhancer starr_16627 Neighboring gene aldehyde dehydrogenase 1 family, member L1 Neighboring gene STARR-positive B cell enhancer ABC_E8115 Neighboring gene predicted gene 15756 Neighboring gene predicted gene, 53296 Neighboring gene IQ motif and Sec7 domain 1 Neighboring gene STARR-positive B cell enhancer ABC_E8116 Neighboring gene STARR-seq mESC enhancer starr_16629 Neighboring gene STARR-positive B cell enhancer ABC_E6454 Neighboring gene STARR-positive B cell enhancer ABC_E10393 Neighboring gene VISTA enhancer mm1470 Neighboring gene STARR-positive B cell enhancer ABC_E10394 Neighboring gene ribosomal protein L21, pseudogene 12 Neighboring gene predicted gene, 25185

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of SLC41A3 as a novel player in magnesium homeostasis. de Baaij JH, et al. Sci Rep, 2016 Jun 28. PMID 27349617, Free PMC Article
  2. SLC41A1 knockout mice display normal magnesium homeostasis. Ilenwabor BP, et al. Am J Physiol Renal Physiol, 2022 Nov 1. PMID 36049064
  3. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article
  4. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
  5. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SLC41A3 was established as a new factor for Mg(2+) handling.
    Title: Identification of SLC41A3 as a novel player in magnesium homeostasis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables magnesium:sodium antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables magnesium:sodium antiporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial magnesium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial magnesium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
solute carrier family 41 member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037493.2 → NP_001032570.1  solute carrier family 41 member 3 isoform 2

    See identical proteins and their annotated locations for NP_001032570.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon and initiates translation at an alternate start codon, compated to variant 1. It encodes isoform 2, which is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK003140, BQ176613
    Consensus CDS
    CCDS20363.1
    UniProtKB/Swiss-Prot
    Q921R8, Q9DC67
    Related
    ENSMUSP00000032177.9, ENSMUST00000032177.10
    Conserved Domains (1) summary
    pfam01769
    Location:80 → 211
    MgtE; Divalent cation transporter

  2. NM_027868.2 → NP_082144.2  solute carrier family 41 member 3 isoform 1

    See identical proteins and their annotated locations for NP_082144.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK003140, AW492407, BB872292, BY108317, CN699671
    Consensus CDS
    CCDS20362.1
    UniProtKB/Swiss-Prot
    Q921R8, Q9DC67
    UniProtKB/TrEMBL
    G3X937
    Related
    ENSMUSP00000037473.10, ENSMUST00000044019.16
    Conserved Domains (1) summary
    pfam01769
    Location:106 → 238
    MgtE; Divalent cation transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    90579043..90623394
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152308.1 → XP_036008201.1  solute carrier family 41 member 3 isoform X1

    UniProtKB/Swiss-Prot
    Q921R8, Q9DC67
    UniProtKB/TrEMBL
    G3X937
    Conserved Domains (1) summary
    pfam01769
    Location:106 → 238
    MgtE; Divalent cation transporter

  2. XM_006506625.3 → XP_006506688.1  solute carrier family 41 member 3 isoform X2

    UniProtKB/Swiss-Prot
    Q921R8, Q9DC67
    Conserved Domains (1) summary
    pfam01769
    Location:270 → 412
    MgtE; Divalent cation transporter

  3. XM_030255596.2 → XP_030111456.1  solute carrier family 41 member 3 isoform X5

    Conserved Domains (1) summary
    pfam01769
    Location:153 → 295
    MgtE; Divalent cation transporter

  4. XM_006506627.5 → XP_006506690.1  solute carrier family 41 member 3 isoform X4

    Conserved Domains (1) summary
    pfam01769
    Location:4 → 136
    MgtE; Divalent cation transporter

  5. XM_006506626.5 → XP_006506689.1  solute carrier family 41 member 3 isoform X3

    UniProtKB/Swiss-Prot
    Q921R8, Q9DC67
    Conserved Domains (1) summary
    pfam01769
    Location:27 → 159
    MgtE; Divalent cation transporter
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q921R8.1 GenPept UniProtKB/Swiss-Prot:Q921R8

Gene LinkOut

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