FASN fatty acid synthase [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: FASNprovided by VGNC
Official Full Name: fatty acid synthaseprovided by VGNC
Primary source: VGNC:VGNC:72616
See related: Ensembl:ENSMMUG00000012811
Gene type: protein coding
RefSeq status: MODEL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 43

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	16	NC_041769.1 (78420668..78440909, complement)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	16	NC_027908.1 (75955211..75975454, complement)

Chromosome 16 - NC_041769.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D17S1256 (e-PCR)
- UniSTS:149801

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables 3-oxoacyl-[acyl-carrier-protein] synthase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables fatty acid synthase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables phosphopantetheine binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: fatty acid synthase

XP_014976113.1

EC 1.1.1.100

EC 1.3.1.39

EC 2.3.1.38

EC 2.3.1.39

EC 2.3.1.41

EC 2.3.1.85

EC 3.1.2.14

EC 4.2.1.59

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041769.1 Reference Mmul_10 Primary Assembly

Range

78420668..78440909 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015120627.2 → XP_014976113.1 fatty acid synthase

UniProtKB/TrEMBL

A0A5K1UCR4, H9FR77, H9Z6B5

Related

ENSMMUP00000016836.4, ENSMMUT00000017977.4

Conserved Domains (11) summary

cd05195
Location:1566 → 1853

enoyl_red; enoyl reductase of polyketide synthase

cd08954
Location:1875 → 2111

KR_1_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 1, complex (x) SDRs

smart00823
Location:2110 → 2178

PKS_PP; Phosphopantetheine attachment site

smart00829
Location:1564 → 1853

PKS_ER; Enoylreductase

COG3321
Location:1 → 1042

PksD; Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]

cd00833
Location:2 → 404

PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...

pfam00698
Location:493 → 810

Acyl_transf_1; Acyl transferase domain

pfam00975
Location:2241 → 2500

Thioesterase; Thioesterase domain

pfam08242
Location:1243 → 1342

Methyltransf_12; Methyltransferase domain

pfam16197
Location:362 → 474

KAsynt_C_assoc; Ketoacyl-synthetase C-terminal extension

cl00509
Location:874 → 1080

hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...