APOE apolipoprotein E [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: APOEprovided by VGNC
Official Full Name: apolipoprotein Eprovided by VGNC
Primary source: VGNC:VGNC:108468
See related: Ensembl:ENSMMUG00000014305
Gene type: protein coding
RefSeq status: MODEL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Also known as: Apo-E
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	19	NC_041772.1 (44944814..44948739)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	19	NC_027911.1 (40213976..40218065)

Chromosome 19 - NC_041772.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In the hippocampus APOE protein levels were higher in good spatial performers than poor spatial performers animals
Title: Association of microtubule associated protein-2, synaptophysin, and apolipoprotein E mRNA and protein levels with cognition and anxiety levels in aged female rhesus macaques.
Allele frequencies of the ApoE gene found show that allele epsilon3 has one of the highest frequencies and epsilon4 allele one of the lowest compared to other population groups in the world
Title: [Genetic polymorphism of apolipoprotein E in a Peruvian population].
There was significantly more apoE immunoreactivity in the prefrontal cortex and hippocampus of aged animals compared to adult or middle-aged animals.
Title: Age-related decreases in SYN levels associated with increases in MAP-2, apoE, and GFAP levels in the rhesus macaque prefrontal cortex and hippocampus.

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General gene information

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Markers

PMC99927P2 (e-PCR)
- UniSTS:273705

GDB:438097 (e-PCR)
- UniSTS:157265

STS-N29699 (e-PCR)
- UniSTS:34644

GDB:169570 (e-PCR)
- UniSTS:154765

GDB:171177 (e-PCR)
- UniSTS:154776

PMC164795P2 (e-PCR)
- UniSTS:271517

GDB:181631 (e-PCR)
- UniSTS:155318

PMC310963P1 (e-PCR)
- UniSTS:272824

PMC310963P2 (e-PCR)
- UniSTS:272825

GDB:181693 (e-PCR)
- UniSTS:155329

PMC117303P1 (e-PCR)
- UniSTS:270328

GDB:196979 (e-PCR)
- UniSTS:155901

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables amyloid-beta binding	IEA Inferred from Electronic Annotation more info	PubMed
enables lipid binding	IEA Inferred from Electronic Annotation more info	PubMed
enables low-density lipoprotein particle receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables very-low-density lipoprotein particle receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cholesterol catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in lipid transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in lipoprotein catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of nitric-oxide synthase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of amyloid-beta clearance	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
part_of intermediate-density lipoprotein particle	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: apolipoprotein E; LOW QUALITY PROTEIN: apolipoprotein E

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041772.1 Reference Mmul_10 Primary Assembly

Range

44944814..44948739

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_028839202.1 → XP_028695035.1 LOW QUALITY PROTEIN: apolipoprotein E

Related

ENSMMUP00000048554.1, ENSMMUT00000058138.2

Conserved Domains (1) summary

pfam01442
Location:113 → 300

Apolipoprotein; Apolipoprotein A1/A4/E domain