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KARS1 lysyl-tRNA synthetase 1 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 714516, updated on 17-Aug-2024

Summary

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Official Symbol
KARS1provided by VGNC
Official Full Name
lysyl-tRNA synthetase 1provided by VGNC
Primary source
VGNC:VGNC:84892
Locus tag
EGK_13013
See related
Ensembl:ENSMMUG00000005754
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Also known as
KARS
Orthologs
human mouse all
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Genomic context

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See KARS1 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
15
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 20 NC_041773.1 (62627505..62647062, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 20 NC_027912.1 (59941893..59961670, complement)

Chromosome 20 - NC_041773.1Genomic Context describing neighboring genes Neighboring gene GABA type A receptor associated protein like 2 Neighboring gene adenosine deaminase tRNA specific 1 Neighboring gene TERF2 interacting protein Neighboring gene uncharacterized LOC114674349 Neighboring gene double homeobox B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
  2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables lysine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in basophil activation involved in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in diadenosine tetraphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in lysyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of macrophage activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of aminoacyl-tRNA synthetase multienzyme complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
lysine--tRNA ligase
NP_001244522.1
XP_014982133.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001257593.1 → NP_001244522.1  lysine--tRNA ligase

    See identical proteins and their annotated locations for NP_001244522.1

    Status: PROVISIONAL

    Source sequence(s)
    JU334405
    UniProtKB/TrEMBL
    A0A8J8Y8G3, F6TVG1, G7NR31, I0FRI7
    Related
    ENSMMUP00000007599.4, ENSMMUT00000008082.4
    Conserved Domains (3) summary
    PLN02502
    Location:43 → 605
    PLN02502; lysyl-tRNA synthetase
    cd00775
    Location:265 → 603
    LysRS_core; Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three ...
    cd04322
    Location:153 → 262
    LysRS_N; LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. ...

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041773.1 Reference Mmul_10 Primary Assembly

    Range
    62627505..62647062 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015126647.2 → XP_014982133.2  lysine--tRNA ligase isoform X1

    UniProtKB/TrEMBL
    A0A5F8AFE5
    Related
    ENSMMUP00000063147.1, ENSMMUT00000090434.1
    Conserved Domains (1) summary
    PLN02502
    Location:62 → 627
    PLN02502; lysyl-tRNA synthetase
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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