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TNS1 tensin 1 [ Homo sapiens (human) ]

Gene ID: 7145, updated on 7-Apr-2024

Summary

Official Symbol
TNS1provided by HGNC
Official Full Name
tensin 1provided by HGNC
Primary source
HGNC:HGNC:11973
See related
Ensembl:ENSG00000079308 MIM:600076; AllianceGenome:HGNC:11973
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TNS; MXRA6; MST091; MST122; MST127; MSTP091; MSTP122; MSTP127; PPP1R155
Summary
The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Expression
Broad expression in fat (RPKM 95.5), lung (RPKM 38.8) and 21 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See TNS1 in Genome Data Viewer
Location:
2q35
Exon count:
48
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (217799791..218033982, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (218283109..218495456, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (218664514..218867718, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene disrupted in renal carcinoma 3 Neighboring gene ATPase H+/K+ transporting non-gastric alpha2 subunit pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17106 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12308 Neighboring gene Sharpr-MPRA regulatory region 7557 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218661013-218661513 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17108 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17109 Neighboring gene RPL7L1 pseudogene 9 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:218678100-218679299 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218684858-218685358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17110 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218737749-218738250 Neighboring gene small nucleolar RNA, H/ACA box 115 Neighboring gene Sharpr-MPRA regulatory region 15318 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:218793628-218794497 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:218794829-218795372 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218798027-218798526 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218799196-218799704 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218799705-218800214 Neighboring gene VISTA enhancer hs1764 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:218808487-218809332 Neighboring gene uncharacterized LOC124905960 Neighboring gene microRNA 6809 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218824713-218825227 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218828984-218829521 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218829522-218830058 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218843426-218844314 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17111 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218859337-218859836 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218860238-218861016 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218861017-218861794 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218866162-218866662 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218866663-218867163 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17112 Neighboring gene uncharacterized LOC124907982 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12309 Neighboring gene TNS1 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:218890081-218890996 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:218896372-218896928 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218899047-218899580 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218899581-218900113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17114 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218910221-218910722 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218930441-218930983 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218933725-218934588 Neighboring gene Sharpr-MPRA regulatory region 3825 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218940751-218941252 Neighboring gene RUN and FYVE domain containing 4 Neighboring gene C-X-C motif chemokine receptor 2 pseudogene 1 Neighboring gene C-X-C motif chemokine receptor 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.
EBI GWAS Catalog
Genome-wide association study identifies five loci associated with lung function.
EBI GWAS Catalog
Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
EBI GWAS Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
EBI GWAS Catalog
Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC88584, DKFZp586K0617

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell-substrate junction assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in fibroblast migration IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in focal adhesion HDA PubMed 
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tensin-1
Names
Matrix-remodelling-associated protein 6
matrix-remodelling associated 6
protein phosphatase 1, regulatory subunit 155

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308022.2NP_001294951.1  tensin-1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks in-frame exon in the central coding region, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AB209238, AC009469, AF225896, AK300345, AK309785, BC051304, BC116187, BC116188, BQ045472
    Consensus CDS
    CCDS77529.1
    UniProtKB/TrEMBL
    E9PF55, Q0VG55
    Related
    ENSP00000408724.1, ENST00000419504.6
    Conserved Domains (4) summary
    cd09927
    Location:14461560
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:77192
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    cd01213
    Location:15821715
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:179305
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein
  2. NM_001308023.2NP_001294952.1  tensin-1 isoform 3

    See identical proteins and their annotated locations for NP_001294952.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, and lacks two consecutive in-frame exons in the central coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC009469
    Consensus CDS
    CCDS77528.1
    UniProtKB/TrEMBL
    A0A087WWW7, E9PGF5, Q0VG54
    Related
    ENSP00000480559.2, ENST00000615025.6
    Conserved Domains (4) summary
    cd09927
    Location:14381553
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:77192
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    cd01213
    Location:15751708
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:179305
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein
  3. NM_001387777.1NP_001374706.1  tensin-1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC009469, AC010136
    Consensus CDS
    CCDS92941.1
    UniProtKB/Swiss-Prot
    A0A804HI61, Q4ZG71, Q6IPI5, Q9HBL0
    UniProtKB/TrEMBL
    A0A494C067
    Related
    ENSP00000506917.1, ENST00000682258.1
    Conserved Domains (6) summary
    cd09927
    Location:15631678
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:8971408
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:17001833
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    cd14560
    Location:139297
    PTP_tensin-1; protein tyrosine phosphatase-like domain of tensin-1
    pfam10409
    Location:304430
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cd20888
    Location:1672
    C1_TNS1_v; protein kinase C conserved region 1 (C1 domain) found in tensin-1 (TNS1) variant and similar proteins
  4. NM_022648.7NP_072174.3  tensin-1 isoform 1

    See identical proteins and their annotated locations for NP_072174.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB209238, AC009469, AF225896, AL706926, BC051304, BC126910, BQ045472
    Consensus CDS
    CCDS2407.1
    UniProtKB/TrEMBL
    B2RU35
    Related
    ENSP00000171887.4, ENST00000171887.8
    Conserved Domains (5) summary
    cd09927
    Location:14591574
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00012
    Location:77192
    PTPc_DSPc; Protein tyrosine phosphatase, catalytic domain, undefined specificity
    cd01213
    Location:15961729
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:179305
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:555944
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    217799791..218033982 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047445637.1XP_047301593.1  tensin-1 isoform X2

  2. XM_047445644.1XP_047301600.1  tensin-1 isoform X12

    UniProtKB/TrEMBL
    A0A2R8Y4T1
    Related
    ENSP00000493967.1, ENST00000646520.1
  3. XM_047445639.1XP_047301595.1  tensin-1 isoform X6

  4. XM_047445638.1XP_047301594.1  tensin-1 isoform X3

  5. XM_047445636.1XP_047301592.1  tensin-1 isoform X1

  6. XM_047445645.1XP_047301601.1  tensin-1 isoform X13

  7. XM_047445642.1XP_047301598.1  tensin-1 isoform X10

  8. XM_047445640.1XP_047301596.1  tensin-1 isoform X8

  9. XM_024453079.2XP_024308847.1  tensin-1 isoform X5

    UniProtKB/TrEMBL
    A0A494C067
    Conserved Domains (5) summary
    cd09927
    Location:17291844
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:7521167
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:18661999
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    cd14560
    Location:139297
    PTP_tensin-1; protein tyrosine phosphatase-like domain of tensin-1
    cl00040
    Location:3467
    C1; protein kinase C conserved region 1 (C1 domain) superfamily
  10. XM_047445641.1XP_047301597.1  tensin-1 isoform X9

  11. XM_024453078.2XP_024308846.2  tensin-1 isoform X4

  12. XM_024453084.2XP_024308852.1  tensin-1 isoform X22

    UniProtKB/TrEMBL
    B2RU35
    Conserved Domains (5) summary
    cd09927
    Location:14591574
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00012
    Location:77192
    PTPc_DSPc; Protein tyrosine phosphatase, catalytic domain, undefined specificity
    cd01213
    Location:15961729
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:179305
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:555944
    Atrophin-1; Atrophin-1 family
  13. XM_047445646.1XP_047301602.1  tensin-1 isoform X14

  14. XM_024453081.2XP_024308849.1  tensin-1 isoform X11

    UniProtKB/TrEMBL
    A0A994J515
    Conserved Domains (5) summary
    cd09927
    Location:16041719
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00012
    Location:77192
    PTPc_DSPc; Protein tyrosine phosphatase, catalytic domain, undefined specificity
    cd01213
    Location:17411874
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:179305
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:6271042
    Atrophin-1; Atrophin-1 family
  15. XM_047445647.1XP_047301603.1  tensin-1 isoform X15

  16. XM_024453080.2XP_024308848.1  tensin-1 isoform X7

    UniProtKB/TrEMBL
    A0A994J515
    Conserved Domains (5) summary
    cd09927
    Location:16691784
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:142257
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    cd01213
    Location:18061939
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:244370
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:6921107
    Atrophin-1; Atrophin-1 family
  17. XM_047445643.1XP_047301599.1  tensin-1 isoform X11

  18. XM_047445650.1XP_047301606.1  tensin-1 isoform X20

  19. XM_047445648.1XP_047301604.1  tensin-1 isoform X18

  20. XM_047445649.1XP_047301605.1  tensin-1 isoform X19

  21. XM_017004814.2XP_016860303.1  tensin-1 isoform X17

  22. XM_047445651.1XP_047301607.1  tensin-1 isoform X21

  23. XM_017004815.2XP_016860304.1  tensin-1 isoform X17

  24. XM_017004813.3XP_016860302.1  tensin-1 isoform X16

    UniProtKB/TrEMBL
    A0A994J515

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    218283109..218495456 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054343623.1XP_054199598.1  tensin-1 isoform X12

    UniProtKB/TrEMBL
    A0A2R8Y4T1
  2. XM_054343616.1XP_054199591.1  tensin-1 isoform X6

  3. XM_054343611.1XP_054199586.1  tensin-1 isoform X3

  4. XM_054343624.1XP_054199599.1  tensin-1 isoform X13

  5. XM_054343620.1XP_054199595.1  tensin-1 isoform X10

  6. XM_054343618.1XP_054199593.1  tensin-1 isoform X8

  7. XM_054343614.1XP_054199589.1  tensin-1 isoform X5

  8. XM_054343607.1XP_054199582.1  tensin-1 isoform X31

  9. XM_054343619.1XP_054199594.1  tensin-1 isoform X9

  10. XM_054343613.1XP_054199588.1  tensin-1 isoform X4

  11. XM_054343638.1XP_054199613.1  tensin-1 isoform X22

  12. XM_054343625.1XP_054199600.1  tensin-1 isoform X37

  13. XM_054343615.1XP_054199590.1  tensin-1 isoform X36

    UniProtKB/TrEMBL
    E9PF55
  14. XM_054343621.1XP_054199596.1  tensin-1 isoform X11

  15. XM_054343626.1XP_054199601.1  tensin-1 isoform X15

  16. XM_054343617.1XP_054199592.1  tensin-1 isoform X7

  17. XM_054343612.1XP_054199587.1  tensin-1 isoform X35

  18. XM_054343603.1XP_054199578.1  tensin-1 isoform X27

  19. XM_054343610.1XP_054199585.1  tensin-1 isoform X34

  20. XM_054343609.1XP_054199584.1  tensin-1 isoform X33

  21. XM_054343608.1XP_054199583.1  tensin-1 isoform X32

  22. XM_054343600.1XP_054199575.1  tensin-1 isoform X24

  23. XM_054343606.1XP_054199581.1  tensin-1 isoform X30

  24. XM_054343605.1XP_054199580.1  tensin-1 isoform X29

  25. XM_054343602.1XP_054199577.1  tensin-1 isoform X26

  26. XM_054343604.1XP_054199579.1  tensin-1 isoform X28

  27. XM_054343601.1XP_054199576.1  tensin-1 isoform X25

  28. XM_054343599.1XP_054199574.1  tensin-1 isoform X23

  29. XM_054343622.1XP_054199597.1  tensin-1 isoform X11

  30. XM_054343628.1XP_054199603.1  tensin-1 isoform X17

  31. XM_054343631.1XP_054199606.1  tensin-1 isoform X19

  32. XM_054343630.1XP_054199605.1  tensin-1 isoform X18

  33. XM_054343632.1XP_054199607.1  tensin-1 isoform X20

  34. XM_054343629.1XP_054199604.1  tensin-1 isoform X17

  35. XM_054343634.1XP_054199609.1  tensin-1 isoform X38

  36. XM_054343633.1XP_054199608.1  tensin-1 isoform X21

  37. XM_054343627.1XP_054199602.1  tensin-1 isoform X16

  38. XM_054343636.1XP_054199611.1  tensin-1 isoform X40

  39. XM_054343635.1XP_054199610.1  tensin-1 isoform X39

  40. XM_054343637.1XP_054199612.1  tensin-1 isoform X41

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_018274.2: Suppressed sequence

    Description
    NM_018274.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.