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Rcbtb1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 [ Mus musculus (house mouse) ]

Gene ID: 71330, updated on 2-Nov-2024

Summary

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Official Symbol
Rcbtb1provided by MGI
Official Full Name
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1provided by MGI
Primary source
MGI:MGI:1918580
See related
Ensembl:ENSMUSG00000035469 AllianceGenome:MGI:1918580
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CLLD7; CLLL7; 5430409I18Rik
Summary
Predicted to be involved in chromatin organization. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in central nervous system and genitourinary system. Orthologous to human RCBTB1 (RCC1 and BTB domain containing protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 17.7), CNS E14 (RPKM 14.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rcbtb1 in Genome Data Viewer
Location:
14 C3; 14 31.47 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (59438471..59474716)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (59201018..59237267)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700129C05 gene Neighboring gene STARR-seq mESC enhancer starr_36836 Neighboring gene predicted gene 5142 Neighboring gene STARR-seq mESC enhancer starr_36837 Neighboring gene PHD finger protein 11 Neighboring gene PHD finger protein 11A Neighboring gene STARR-positive B cell enhancer mm9_chr14:59916339-59916640

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The ubiquitin conjugating enzyme, UbcM2, engages in novel interactions with components of cullin-3 based E3 ligases. Plafker KS, et al. Biochemistry, 2009 Apr 21. PMID 19256485, Free PMC Article
  2. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
  3. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
  4. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
  5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RCC1 and BTB domain-containing protein 1
Names
regulator of chromosome condensation and BTB domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360610.1 → NP_001347539.1  RCC1 and BTB domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC166169, BC040764, BC067005, BQ179206
    Consensus CDS
    CCDS27168.1
    UniProtKB/Swiss-Prot
    Q6NXM2, Q8BTZ6, Q8BZV0
    UniProtKB/TrEMBL
    A0A0R4J025
    Related
    ENSMUSP00000022551.8, ENSMUST00000022551.14
    Conserved Domains (3) summary
    COG5184
    Location:43 → 316
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd18353
    Location:350 → 466
    BTB_POZ_RCBTB1_CLLD7; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1)
    cd18528
    Location:466 → 531
    BACK_RCBTB1; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1)

  2. NM_001360611.1 → NP_001347540.1  RCC1 and BTB domain-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC166169, AK017287, BC067005, CA325180
    UniProtKB/TrEMBL
    Q9D3M1
    Related
    ENSMUST00000095778.8
    Conserved Domains (1) summary
    cl27697
    Location:30 → 153
    RCC1; Regulator of chromosome condensation (RCC1) repeat

  3. NM_027764.2 → NP_082040.2  RCC1 and BTB domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_082040.2

    Status: VALIDATED

    Source sequence(s)
    AK033501, BC040764, CJ183647
    Consensus CDS
    CCDS27168.1
    UniProtKB/Swiss-Prot
    Q6NXM2, Q8BTZ6, Q8BZV0
    UniProtKB/TrEMBL
    A0A0R4J025
    Related
    ENSMUSP00000037030.7, ENSMUST00000043227.13
    Conserved Domains (3) summary
    COG5184
    Location:43 → 316
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd18353
    Location:350 → 466
    BTB_POZ_RCBTB1_CLLD7; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1)
    cd18528
    Location:466 → 531
    BACK_RCBTB1; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    59438471..59474716
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248032.2 → XP_030103892.1  RCC1 and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q6NXM2, Q8BTZ6, Q8BZV0
    UniProtKB/TrEMBL
    A0A0R4J025
    Conserved Domains (3) summary
    COG5184
    Location:43 → 316
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd18353
    Location:350 → 466
    BTB_POZ_RCBTB1_CLLD7; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1)
    cd18528
    Location:466 → 531
    BACK_RCBTB1; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1)

  2. XM_017316204.3 → XP_017171693.1  RCC1 and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q6NXM2, Q8BTZ6, Q8BZV0
    UniProtKB/TrEMBL
    A0A0R4J025
    Conserved Domains (3) summary
    COG5184
    Location:43 → 316
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd18353
    Location:350 → 466
    BTB_POZ_RCBTB1_CLLD7; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1)
    cd18528
    Location:466 → 531
    BACK_RCBTB1; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1)

  3. XM_006519566.4 → XP_006519629.1  RCC1 and BTB domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006519629.1

    UniProtKB/Swiss-Prot
    Q6NXM2, Q8BTZ6, Q8BZV0
    UniProtKB/TrEMBL
    A0A0R4J025
    Conserved Domains (3) summary
    COG5184
    Location:43 → 316
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd18353
    Location:350 → 466
    BTB_POZ_RCBTB1_CLLD7; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1)
    cd18528
    Location:466 → 531
    BACK_RCBTB1; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1)

  4. XM_006519569.4 → XP_006519632.1  RCC1 and BTB domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006519632.1

    UniProtKB/Swiss-Prot
    Q6NXM2, Q8BTZ6, Q8BZV0
    UniProtKB/TrEMBL
    A0A0R4J025
    Conserved Domains (3) summary
    COG5184
    Location:43 → 316
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd18353
    Location:350 → 466
    BTB_POZ_RCBTB1_CLLD7; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1)
    cd18528
    Location:466 → 531
    BACK_RCBTB1; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1)

  5. XM_006519567.4 → XP_006519630.1  RCC1 and BTB domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006519630.1

    UniProtKB/Swiss-Prot
    Q6NXM2, Q8BTZ6, Q8BZV0
    UniProtKB/TrEMBL
    A0A0R4J025
    Conserved Domains (3) summary
    COG5184
    Location:43 → 316
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd18353
    Location:350 → 466
    BTB_POZ_RCBTB1_CLLD7; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1)
    cd18528
    Location:466 → 531
    BACK_RCBTB1; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1)

  6. XM_030248034.2 → XP_030103894.1  RCC1 and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q6NXM2, Q8BTZ6, Q8BZV0
    UniProtKB/TrEMBL
    A0A0R4J025
    Conserved Domains (3) summary
    COG5184
    Location:43 → 316
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd18353
    Location:350 → 466
    BTB_POZ_RCBTB1_CLLD7; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1)
    cd18528
    Location:466 → 531
    BACK_RCBTB1; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1)

  7. XM_030248033.2 → XP_030103893.1  RCC1 and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q6NXM2, Q8BTZ6, Q8BZV0
    UniProtKB/TrEMBL
    A0A0R4J025
    Conserved Domains (3) summary
    COG5184
    Location:43 → 316
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd18353
    Location:350 → 466
    BTB_POZ_RCBTB1_CLLD7; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1)
    cd18528
    Location:466 → 531
    BACK_RCBTB1; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1)

  8. XM_017316205.3 → XP_017171694.1  RCC1 and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q6NXM2, Q8BTZ6, Q8BZV0
    UniProtKB/TrEMBL
    A0A0R4J025
    Conserved Domains (3) summary
    COG5184
    Location:43 → 316
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd18353
    Location:350 → 466
    BTB_POZ_RCBTB1_CLLD7; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1)
    cd18528
    Location:466 → 531
    BACK_RCBTB1; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1)

RNA

  1. XR_003950902.2 RNA Sequence

  2. XR_004938447.1 RNA Sequence

  3. XR_003950901.2 RNA Sequence

  4. XR_383211.5 RNA Sequence

  5. XR_004938446.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NXM2.1 GenPept UniProtKB/Swiss-Prot:Q6NXM2

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