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Ccdc57 coiled-coil domain containing 57 [ Mus musculus (house mouse) ]

Gene ID: 71276, updated on 2-Nov-2024

Summary

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Official Symbol
Ccdc57provided by MGI
Official Full Name
coiled-coil domain containing 57provided by MGI
Primary source
MGI:MGI:1918526
See related
Ensembl:ENSMUSG00000048445 AllianceGenome:MGI:1918526
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4933434G05Rik
Summary
Involved in cilium assembly. Predicted to be located in centrosome. Predicted to be active in centriolar satellite; centriole; and spindle microtubule. Orthologous to human CCDC57 (coiled-coil domain containing 57). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 4.0), ovary adult (RPKM 2.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ccdc57 in Genome Data Viewer
Location:
11 E2; 11 84.59 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120717355..120823703, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120826529..120932926, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:120657732-120657915 Neighboring gene G protein pathway suppressor 1 Neighboring gene dihydrouridine synthase 1 like Neighboring gene STARR-positive B cell enhancer ABC_E9039 Neighboring gene fatty acid synthase Neighboring gene STARR-seq mESC enhancer starr_31373 Neighboring gene RIKEN cDNA A430102A20 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:120794121-120794304 Neighboring gene STARR-seq mESC enhancer starr_31376 Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 3 Neighboring gene casein kinase 1, delta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CCDC57 Cooperates with Microtubules and Microcephaly Protein CEP63 and Regulates Centriole Duplication and Mitotic Progression. Gurkaslar HK, et al. Cell Rep, 2020 May 12. PMID 32402286
  2. Post-entrapment genome engineering: first exon size does not affect the expression of fusion transcripts generated by gene entrapment. Osipovich AB, et al. Genome Res, 2005 Mar. PMID 15741512, Free PMC Article
  3. Mutagenesis of diploid mammalian genes by gene entrapment. Lin Q, et al. Nucleic Acids Res, 2006. PMID 17062627, Free PMC Article
  4. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in G2/M transition of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in centriole replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in centriole replication ISO
Inferred from Sequence Orthology
more info
  
involved_in centriole replication ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule nucleation ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule nucleation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in centriolar satellite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in centriolar satellite ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in centriole ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in spindle microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
coiled-coil domain-containing protein 57
NP_001404939.1
NP_082021.1
XP_006534297.1
XP_017170256.1
XP_030102182.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418010.1 → NP_001404939.1  coiled-coil domain-containing protein 57 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL662901, AL663090

  2. NM_027745.2 → NP_082021.1  coiled-coil domain-containing protein 57 isoform 1

    See identical proteins and their annotated locations for NP_082021.1

    Status: VALIDATED

    Source sequence(s)
    AL662901, AL663090
    Consensus CDS
    CCDS25760.1
    UniProtKB/Swiss-Prot
    Q6PHN1
    Related
    ENSMUSP00000050996.5, ENSMUST00000056781.5
    Conserved Domains (3) summary
    PHA03307
    Location:790 → 1008
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:3 → 320
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:7 → 698
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RNA

  1. NR_184673.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL662901, AL663090

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    120717355..120823703 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246322.1 → XP_030102182.1  coiled-coil domain-containing protein 57 isoform X4

    Conserved Domains (2) summary
    PHA03307
    Location:421 → 639
    PHA03307; transcriptional regulator ICP4; Provisional
    TIGR02169
    Location:15 → 326
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  2. XM_017314767.3 → XP_017170256.1  coiled-coil domain-containing protein 57 isoform X1

    UniProtKB/Swiss-Prot
    Q6PHN1
    Conserved Domains (3) summary
    PHA03307
    Location:790 → 1008
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:3 → 320
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:7 → 698
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  3. XM_006534234.3 → XP_006534297.1  coiled-coil domain-containing protein 57 isoform X3

    Conserved Domains (2) summary
    PHA03307
    Location:623 → 841
    PHA03307; transcriptional regulator ICP4; Provisional
    TIGR02168
    Location:14 → 386
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RNA

  1. XR_004937031.1 RNA Sequence

  2. XR_004937029.1 RNA Sequence

  3. XR_001780051.3 RNA Sequence

  4. XR_003949508.2 RNA Sequence

  5. XR_001780052.3 RNA Sequence

  6. XR_004937034.1 RNA Sequence

  7. XR_004937033.1 RNA Sequence

  8. XR_004937032.1 RNA Sequence

  9. XR_001780053.3 RNA Sequence

  10. XR_003949507.2 RNA Sequence

  11. XR_004937030.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PHN1.1 GenPept UniProtKB/Swiss-Prot:Q6PHN1

Gene LinkOut

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