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Osbpl7 oxysterol binding protein-like 7 [ Mus musculus (house mouse) ]

Gene ID: 71240, updated on 28-Oct-2024

Summary

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Official Symbol
Osbpl7provided by MGI
Official Full Name
oxysterol binding protein-like 7provided by MGI
Primary source
MGI:MGI:1918490
See related
Ensembl:ENSMUSG00000038534 AllianceGenome:MGI:1918490
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4933437E18Rik
Summary
Predicted to enable cholesterol binding activity. Predicted to be involved in cellular response to cholesterol and positive regulation of proteasomal protein catabolic process. Predicted to be located in autophagosome and nucleoplasm. Predicted to be active in several cellular components, including cytosol; nuclear membrane; and perinuclear endoplasmic reticulum. Is expressed in several structures, including central nervous system; genitourinary system; immune system; liver; and lung. Orthologous to human OSBPL7 (oxysterol binding protein like 7). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in colon adult (RPKM 18.6), testis adult (RPKM 16.6) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Osbpl7 in Genome Data Viewer
Location:
11 D; 11 60.75 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (96941459..96959730)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (97050633..97068904)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E909 Neighboring gene leucine rich repeat containing 46 Neighboring gene predicted gene 11533 Neighboring gene STARR-positive B cell enhancer ABC_E8445 Neighboring gene mitochondrial ribosomal protein L10 Neighboring gene predicted gene, 51917 Neighboring gene microRNA 8103 Neighboring gene STARR-seq mESC enhancer starr_30581 Neighboring gene T-box 21 Neighboring gene STARR-positive B cell enhancer ABC_E8446 Neighboring gene TBK1 binding protein 1 Neighboring gene microRNA 7235

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Oxysterol-binding protein-like 7 deficiency leads to ER stress-mediated apoptosis in podocytes and proteinuria. Duara J, et al. Am J Physiol Renal Physiol, 2024 Sep 1. PMID 38961844,
  2. An oxysterol-binding protein family identified in the mouse. Anniss AM, et al. DNA Cell Biol, 2002 Aug. PMID 12215260
  3. Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling. Angrand PO, et al. Mol Cell Proteomics, 2006 Dec. PMID 16959763
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Oxysterol-binding protein-like 7 deficiency leads to ER stress-mediated apoptosis in podocytes and proteinuria.
    Title: Oxysterol-binding protein-like 7 deficiency leads to ER stress-mediated apoptosis in podocytes and proteinuria.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cholesterol binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to cholesterol ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in autophagosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in perinuclear endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
oxysterol-binding protein-related protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310509.2 → NP_001297438.2  oxysterol-binding protein-related protein 7

    Status: VALIDATED

    Source sequence(s)
    AK017095, AK171585, AL606664, BE990127, BY593908
    Consensus CDS
    CCDS79034.2
    UniProtKB/TrEMBL
    A2A716, Q3TAX1
    Related
    ENSMUSP00000087474.7, ENSMUST00000090020.13
    Conserved Domains (2) summary
    cd13287
    Location:27 → 149
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:473 → 814
    Oxysterol_BP; Oxysterol-binding protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    96941459..96959730
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249264.2 → XP_011247566.1  oxysterol-binding protein-related protein 7 isoform X1

    Conserved Domains (2) summary
    cd13287
    Location:153 → 275
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:640 → 987
    Oxysterol_BP; Oxysterol-binding protein

  2. XM_036156991.1 → XP_036012884.1  oxysterol-binding protein-related protein 7 isoform X3

    Conserved Domains (1) summary
    cd13287
    Location:153 → 275
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain

  3. XM_036156990.1 → XP_036012883.1  oxysterol-binding protein-related protein 7 isoform X2

    Conserved Domains (2) summary
    pfam01237
    Location:372 → 719
    Oxysterol_BP; Oxysterol-binding protein
    cl17171
    Location:1 → 48
    PH-like; Pleckstrin homology-like domain

RNA

  1. XR_879739.2 RNA Sequence

  2. XR_003949505.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001081434.1: Suppressed sequence

    Description
    NM_001081434.1: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
Nucleotide Protein Strain
Heading Accession and Version

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