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Zfp626 zinc finger protein 626 [ Mus musculus (house mouse) ]

Gene ID: 71163, updated on 17-Aug-2024

Summary

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Official Symbol
Zfp626provided by MGI
Official Full Name
zinc finger protein 626provided by MGI
Primary source
MGI:MGI:1918413
See related
Ensembl:ENSMUSG00000030604 AllianceGenome:MGI:1918413
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4833408D11Rik; 4933426I21Rik; 7630402I04Rik
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Is expressed in genitourinary system. Orthologous to human ZNF780A (zinc finger protein 780A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 1.5), CNS E11.5 (RPKM 1.5) and 24 other tissues See more
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Genomic context

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See Zfp626 in Genome Data Viewer
Location:
7 A3; 7 15.97 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (27504165..27522348)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (27804731..27822923)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 10046 Neighboring gene predicted gene, 29810 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:28589770-28589879 Neighboring gene STARR-seq mESC enhancer starr_18392 Neighboring gene zinc finger protein 59 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:28645358-28645700 Neighboring gene zinc finger protein 607A Neighboring gene protein kinase C, zeta 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  2. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  3. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 626

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403469.1 → NP_001390398.1  zinc finger protein 626

    Status: VALIDATED

    Source sequence(s)
    AC164532
    UniProtKB/TrEMBL
    A0A0U1RQ84

  2. NM_027703.2 → NP_081979.1  zinc finger protein 626

    Status: VALIDATED

    Source sequence(s)
    AC164532
    Consensus CDS
    CCDS85250.1
    UniProtKB/TrEMBL
    A0A0U1RQ84
    Related
    ENSMUSP00000146286.2, ENSMUST00000205671.2
    Conserved Domains (4) summary
    smart00349
    Location:14 → 75
    KRAB; krueppel associated box
    COG5048
    Location:170 → 572
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:427 → 447
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:607 → 631
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    27504165..27522348
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312305.1 → XP_017167794.1  zinc finger protein 626 isoform X2

    Conserved Domains (3) summary
    COG5048
    Location:129 → 531
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:386 → 406
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:2 → 34
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
Nucleotide Protein Strain
Heading Accession and Version

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