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DGKA diacylglycerol kinase alpha [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 710559, updated on 18-Sep-2024

Summary

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Official Symbol
DGKAprovided by VGNC
Official Full Name
diacylglycerol kinase alphaprovided by VGNC
Primary source
VGNC:VGNC:71780
Locus tag
EGK_03778
See related
Ensembl:ENSMMUG00000018814
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See DGKA in Genome Data Viewer
Location:
chromosome: 11
Exon count:
27
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 11 NC_041764.1 (55486216..55508747)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 11 NC_027903.1 (54659046..54681961)

Chromosome 11 - NC_041764.1Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase P pseudogene Neighboring gene PYM homolog 1, exon junction complex associated factor Neighboring gene premelanosome protein Neighboring gene cyclin dependent kinase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP-dependent diacylglycerol kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in diacylglycerol metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in lipid phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
diacylglycerol kinase alpha
Names
diacylglycerol kinase, alpha 80kDa
XP_001112709.2
XP_015007417.1
XP_028685422.1
XP_028685423.1
XP_028685424.1
XP_028685425.1
XP_028685426.1
XP_028685427.1
XP_028685428.1
XP_028685429.1
XP_028685430.1
XP_028685432.1
XP_028685433.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041764.1 Reference Mmul_10 Primary Assembly

    Range
    55486216..55508747
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_028829595.1 → XP_028685428.1  diacylglycerol kinase alpha isoform X6

    UniProtKB/TrEMBL
    F7BND6
    Conserved Domains (6) summary
    smart00045
    Location:566 → 747
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:424 → 545
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    pfam14513
    Location:4 → 110
    DAG_kinase_N; Diacylglycerol kinase N-terminus
    cd20799
    Location:247 → 307
    C1_DGK_typeI_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type I diacylglycerol kinases
    cd20890
    Location:316 → 377
    C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
    cl08302
    Location:114 → 229
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  2. XM_001112709.4 → XP_001112709.2  diacylglycerol kinase alpha isoform X8

    UniProtKB/TrEMBL
    A0A5F8AM07, A0A8J8XWB0, F7BND6, G7N7A5
    Related
    ENSMMUP00000078950.1, ENSMMUT00000086895.1
    Conserved Domains (5) summary
    smart00045
    Location:520 → 701
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:378 → 499
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00051
    Location:114 → 183
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam14513
    Location:6 → 110
    DAG_kinase_N; Diacylglycerol kinase N-terminus
    pfam00130
    Location:206 → 254
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  3. XM_028829591.1 → XP_028685424.1  diacylglycerol kinase alpha isoform X3

    UniProtKB/TrEMBL
    A0A5F7ZGN9
    Conserved Domains (5) summary
    smart00045
    Location:619 → 800
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:477 → 598
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    pfam14513
    Location:6 → 163
    DAG_kinase_N; Diacylglycerol kinase N-terminus
    cl08302
    Location:167 → 282
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:305 → 353
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  4. XM_028829597.1 → XP_028685430.1  diacylglycerol kinase alpha isoform X6

    UniProtKB/TrEMBL
    F7BND6
    Conserved Domains (6) summary
    smart00045
    Location:566 → 747
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:424 → 545
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    pfam14513
    Location:4 → 110
    DAG_kinase_N; Diacylglycerol kinase N-terminus
    cd20799
    Location:247 → 307
    C1_DGK_typeI_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type I diacylglycerol kinases
    cd20890
    Location:316 → 377
    C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
    cl08302
    Location:114 → 229
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  5. XM_028829596.1 → XP_028685429.1  diacylglycerol kinase alpha isoform X6

    UniProtKB/TrEMBL
    F7BND6
    Conserved Domains (6) summary
    smart00045
    Location:566 → 747
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:424 → 545
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    pfam14513
    Location:4 → 110
    DAG_kinase_N; Diacylglycerol kinase N-terminus
    cd20799
    Location:247 → 307
    C1_DGK_typeI_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type I diacylglycerol kinases
    cd20890
    Location:316 → 377
    C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
    cl08302
    Location:114 → 229
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  6. XM_028829599.1 → XP_028685432.1  diacylglycerol kinase alpha isoform X8

    UniProtKB/TrEMBL
    A0A5F8AM07, A0A8J8XWB0, F7BND6, G7N7A5
    Conserved Domains (5) summary
    smart00045
    Location:520 → 701
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:378 → 499
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00051
    Location:114 → 183
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam14513
    Location:6 → 110
    DAG_kinase_N; Diacylglycerol kinase N-terminus
    pfam00130
    Location:206 → 254
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  7. XM_028829600.1 → XP_028685433.1  diacylglycerol kinase alpha isoform X9

    UniProtKB/TrEMBL
    H9F8X8
    Conserved Domains (5) summary
    smart00045
    Location:379 → 560
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:237 → 358
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd20799
    Location:60 → 120
    C1_DGK_typeI_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type I diacylglycerol kinases
    cd20890
    Location:129 → 190
    C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
    cl08302
    Location:1 → 42
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  8. XM_028829592.1 → XP_028685425.1  diacylglycerol kinase alpha isoform X3

    UniProtKB/TrEMBL
    A0A5F7ZGN9
    Related
    ENSMMUP00000063604.1, ENSMMUT00000079358.1
    Conserved Domains (5) summary
    smart00045
    Location:619 → 800
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:477 → 598
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    pfam14513
    Location:6 → 163
    DAG_kinase_N; Diacylglycerol kinase N-terminus
    cl08302
    Location:167 → 282
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:305 → 353
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  9. XM_015151931.2 → XP_015007417.1  diacylglycerol kinase alpha isoform X7

    UniProtKB/TrEMBL
    F6ZHF9, F7BND6
    Related
    ENSMMUP00000024762.4, ENSMMUT00000026454.4
    Conserved Domains (7) summary
    smart00045
    Location:558 → 739
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:416 → 537
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:416 → 749
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    cd00051
    Location:152 → 221
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:244 → 292
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam13499
    Location:153 → 217
    EF-hand_7; EF-hand domain pair
    pfam14513
    Location:44 → 148
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  10. XM_028829594.1 → XP_028685427.1  diacylglycerol kinase alpha isoform X5

    UniProtKB/TrEMBL
    F7BND6
    Conserved Domains (5) summary
    smart00045
    Location:604 → 785
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:462 → 583
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    pfam14513
    Location:44 → 148
    DAG_kinase_N; Diacylglycerol kinase N-terminus
    cl08302
    Location:152 → 267
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:290 → 338
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  11. XM_028829589.1 → XP_028685422.1  diacylglycerol kinase alpha isoform X1

    UniProtKB/TrEMBL
    A0A5F7ZGN9
    Conserved Domains (5) summary
    smart00045
    Location:657 → 838
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:515 → 636
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    pfam14513
    Location:44 → 201
    DAG_kinase_N; Diacylglycerol kinase N-terminus
    cl08302
    Location:205 → 320
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:343 → 391
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  12. XM_028829590.1 → XP_028685423.1  diacylglycerol kinase alpha isoform X2

    UniProtKB/TrEMBL
    A0A5F7ZGN9
    Conserved Domains (5) summary
    smart00045
    Location:640 → 821
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:505 → 619
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    pfam14513
    Location:44 → 201
    DAG_kinase_N; Diacylglycerol kinase N-terminus
    cl08302
    Location:205 → 320
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:343 → 391
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  13. XM_028829593.1 → XP_028685426.1  diacylglycerol kinase alpha isoform X4

    UniProtKB/TrEMBL
    A0A5F7ZGN9
    Conserved Domains (5) summary
    smart00045
    Location:611 → 792
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:469 → 590
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00051
    Location:205 → 274
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam14513
    Location:44 → 201
    DAG_kinase_N; Diacylglycerol kinase N-terminus
    pfam00130
    Location:297 → 345
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
Nucleotide Protein
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