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Mgat4e MGAT4 family, member E [ Mus musculus (house mouse) ]

Gene ID: 71001, updated on 2-Nov-2024

Summary

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Official Symbol
Mgat4eprovided by MGI
Official Full Name
MGAT4 family, member Eprovided by MGI
Primary source
MGI:MGI:1918251
See related
Ensembl:ENSMUSG00000046367 AllianceGenome:MGI:1918251
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4931440L10Rik
Summary
Predicted to enable acetylglucosaminyltransferase activity. Predicted to be involved in protein N-linked glycosylation. Orthologous to human MGAT4EP (MGAT4 family member E, pseudogene). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 29.3) See more
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Genomic context

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See Mgat4e in Genome Data Viewer
Location:
1 E4; 1 58.24 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (134468679..134489484, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (134540941..134561746, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02337 Neighboring gene tubulin alpha 5, pseudogene Neighboring gene STARR-seq mESC enhancer starr_02338 Neighboring gene predicted gene 15454 Neighboring gene STARR-positive B cell enhancer ABC_E10037 Neighboring gene predicted gene, 46159 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:136456618-136456805 Neighboring gene STARR-seq mESC enhancer starr_02340 Neighboring gene predicted gene, 46160 Neighboring gene STARR-seq mESC enhancer starr_02343 Neighboring gene lysine demethylase 5B Neighboring gene STARR-seq mESC enhancer starr_02345 Neighboring gene synaptotagmin II Neighboring gene protein phosphatase 1, regulatory subunit 12B Neighboring gene predicted gene, 32670

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145300.2 → NP_001138772.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4E isoform 1

    See identical proteins and their annotated locations for NP_001138772.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC122771
    Consensus CDS
    CCDS48370.1
    UniProtKB/Swiss-Prot
    A6H684, B7ZNB9, E9Q5L0, Q8C1J0
    Related
    ENSMUSP00000133717.2, ENSMUST00000172898.2
    Conserved Domains (1) summary
    cl04660
    Location:49 → 273
    PGAP4-like; Post-GPI attachment to proteins factor 4 and similar proteins

  2. NM_001291015.1 → NP_001277944.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4E isoform 2

    See identical proteins and their annotated locations for NP_001277944.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC122771
    UniProtKB/Swiss-Prot
    A6H684
    Conserved Domains (1) summary
    pfam04666
    Location:1 → 191
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    134468679..134489484 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248086.3 → XP_011246388.2  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4E isoform X1

    Conserved Domains (1) summary
    pfam04666
    Location:57 → 295
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_183292.1: Suppressed sequence

    Description
    NM_183292.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6H684.3 GenPept UniProtKB/Swiss-Prot:A6H684

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