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TLE2 TLE family member 2, transcriptional corepressor [ Homo sapiens (human) ]

Gene ID: 7089, updated on 5-Mar-2024

Summary

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Official Symbol
TLE2provided by HGNC
Official Full Name
TLE family member 2, transcriptional corepressorprovided by HGNC
Primary source
HGNC:HGNC:11838
See related
Ensembl:ENSG00000065717 MIM:601041; AllianceGenome:HGNC:11838
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ESG; ESG2; GRG2
Summary
Enables transcription corepressor activity. Involved in negative regulation of canonical Wnt signaling pathway and negative regulation of transcription, DNA-templated. Located in focal adhesion and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in salivary gland (RPKM 17.9), fat (RPKM 13.6) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
19p13.3
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (2997644..3047635, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (2971143..3021120, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (2997642..3047633, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9817 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9818 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13722 Neighboring gene zinc finger protein 77 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13723 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9819 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:2982456-2982974 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:2982975-2983491 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr19:2984010-2984526 Neighboring gene TLE family member 6, subcortical maternal complex member Neighboring gene ReSE screen-validated silencer GRCh37_chr19:3003179-3003325 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:3006113-3007047 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:3007156-3007353 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13724 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9820 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9821 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:3041680-3041803 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:3054606-3055171 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:3057431-3057995 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:3057996-3058560 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:3059514-3059717 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9822 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9823 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9824 Neighboring gene uncharacterized LOC105372242 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:3066867-3067075 Neighboring gene TLE family member 5, transcriptional modulator Neighboring gene Sharpr-MPRA regulatory region 11171

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cellular corepressor TLE2 inhibits replication-and-transcription- activator-mediated transactivation and lytic reactivation of Kaposi's sarcoma-associated herpesvirus. He Z, et al. J Virol, 2010 Feb. PMID 19939918, Free PMC Article
  2. Groucho/TLE/R-esp proteins associate with the nuclear matrix and repress RUNX (CBF(alpha)/AML/PEBP2(alpha)) dependent activation of tissue-specific gene transcription. Javed A, et al. J Cell Sci, 2000 Jun. PMID 10825294
  3. Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia. Liu Y, et al. Genomics, 1996 Jan 1. PMID 8808280
  4. PRDI-BF1/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins. Ren B, et al. Genes Dev, 1999 Jan 1. PMID 9887105, Free PMC Article
  5. Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development. Grbavec D, et al. Eur J Biochem, 1998 Dec 1. PMID 9874198

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Immunofluorescence analysis showed that TLE2 and RTA were colocalized in the same nuclear compartment in KSHV-infected cells.
    Title: Cellular corepressor TLE2 inhibits replication-and-transcription- activator-mediated transactivation and lytic reactivation of Kaposi's sarcoma-associated herpesvirus.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ41188

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in animal organ morphogenesis TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space HDA PubMed 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
  
located_in nuclear body IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transducin-like enhancer protein 2
Names
enhancer of split groucho-like protein 2
transducin like enhancer of split 2
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
transducin-like enhancer of split 2, homolog of Drosophila E(sp1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144761.2 → NP_001138233.1  transducin-like enhancer protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences compared to variant 4, one of which results in a frameshift. This results in a shorter isoform (2) with distinct N- and C-termini compared to isoform 4.
    Source sequence(s)
    AK308137, BC017364
    Consensus CDS
    CCDS45913.1
    UniProtKB/Swiss-Prot
    Q04725
    Related
    ENSP00000468279.1, ENST00000591529.5
    Conserved Domains (4) summary
    COG2319
    Location:469 → 693
    WD40; WD40 repeat [General function prediction only]
    pfam03920
    Location:18 → 141
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:474 → 513
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:463 → 631
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001144762.2 → NP_001138234.1  transducin-like enhancer protein 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences compared to variant 4. This results in a shorter isoform (2) with a shorter N-terminus compared to isoform 4.
    Source sequence(s)
    AC011549, AK293407, BC017364
    Consensus CDS
    CCDS45912.1
    UniProtKB/Swiss-Prot
    Q04725
    Related
    ENSP00000392427.2, ENST00000443826.7
    Conserved Domains (4) summary
    COG2319
    Location:333 → 619
    WD40; WD40 repeat [General function prediction only]
    pfam03920
    Location:1 → 68
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:338 → 377
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:334 → 618
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. NM_001300846.2 → NP_001287775.1  transducin-like enhancer protein 2 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (4).
    Source sequence(s)
    AC011549, AK312285, BC017364, HY046309, HY140405
    Consensus CDS
    CCDS74255.1
    UniProtKB/TrEMBL
    K7EMK7
    Related
    ENSP00000466542.1, ENST00000590536.5
    Conserved Domains (4) summary
    COG2319
    Location:456 → 742
    WD40; WD40 repeat [General function prediction only]
    pfam03920
    Location:1 → 128
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:461 → 500
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:457 → 741
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. NM_003260.5 → NP_003251.2  transducin-like enhancer protein 2 isoform 1

    See identical proteins and their annotated locations for NP_003251.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 5' coding region, compared to variant 4. It encodes isoform 1, which is shorter by an amino acid, compared to isoform 4.
    Source sequence(s)
    AC011549, AW262763, BC017364
    Consensus CDS
    CCDS45911.1
    UniProtKB/Swiss-Prot
    B4DE03, E9PEV7, F8WCH2, Q04725, Q8WVY0, Q9Y6S0
    Related
    ENSP00000262953.5, ENST00000262953.11
    Conserved Domains (4) summary
    sd00039
    Location:460 → 499
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:1 → 132
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    cl25539
    Location:456 → 740
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl26464
    Location:126 → 366
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    2997644..3047635 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528230.2 → XP_011526532.1  transducin-like enhancer protein 2 isoform X1

    Conserved Domains (4) summary
    COG2319
    Location:444 → 730
    WD40; WD40 repeat [General function prediction only]
    pfam03920
    Location:1 → 128
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:449 → 488
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:445 → 729
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_006722864.3 → XP_006722927.1  transducin-like enhancer protein 2 isoform X2

    Conserved Domains (4) summary
    COG2319
    Location:456 → 680
    WD40; WD40 repeat [General function prediction only]
    pfam03920
    Location:1 → 128
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:461 → 500
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:450 → 618
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    2971143..3021120 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321901.1 → XP_054177876.1  transducin-like enhancer protein 2 isoform X1

  2. XM_054321902.1 → XP_054177877.1  transducin-like enhancer protein 2 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04725.2 GenPept UniProtKB/Swiss-Prot:Q04725

Gene LinkOut

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