TLE1 TLE family member 1, transcriptional corepressor [Homo sapiens (human)] - Gene

Summary

Official Symbol: TLE1provided by HGNC
Official Full Name: TLE family member 1, transcriptional corepressorprovided by HGNC
Primary source: HGNC:HGNC:11837
See related: Ensembl:ENSG00000196781 MIM:600189; AllianceGenome:HGNC:11837
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ESG; ESG1; GRG1; TLE-1
Summary: Enables identical protein binding activity and transcription corepressor activity. Involved in negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of anoikis; and regulation of gene expression. Located in cytosol and nucleoplasm. Part of beta-catenin-TCF complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in fat (RPKM 15.1), endometrium (RPKM 10.2) and 25 other tissues See more
Orthologs: all
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Genomic context

Location:: 9q21.32

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (81583683..81689547, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (93735751..93841617, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (84198598..84304462, complement)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GRg1 inhibits the TLR4/NF-kB signaling pathway by upregulating miR-216a-5p to reduce growth factors and inflammatory cytokines in DR.
Title: GRg1 inhibits the TLR4/NF-kB signaling pathway by upregulating miR-216a-5p to reduce growth factors and inflammatory cytokines in DR.
Expression of TLE-1 in Gastrointestinal Stromal Tumour and Its Relationship to Clinicopathological Parameters.
Title: Expression of TLE-1 in Gastrointestinal Stromal Tumour and Its Relationship to Clinicopathological Parameters.
Prognostic Value of TLE1 Gene Expression in Patients with T-cell Acute Lymphoblastic Leukemia.
Title: Prognostic Value of TLE1 Gene Expression in Patients with T-cell Acute Lymphoblastic Leukemia.
Tissue microarray based immunohistochemical study of TLE1 in synovial sarcoma and its histologic mimics.
Title: Tissue microarray based immunohistochemical study of TLE1 in synovial sarcoma and its histologic mimics.
lncRNA RASSF8AS1 suppresses the progression of laryngeal squamous cell carcinoma via targeting the miR664b3p/TLE1 axis.
Title: lncRNA RASSF8‑AS1 suppresses the progression of laryngeal squamous cell carcinoma via targeting the miR‑664b‑3p/TLE1 axis.
Differential functions of TLE1 and TLE3 depending on a specific phosphorylation site.
Title: Differential functions of TLE1 and TLE3 depending on a specific phosphorylation site.
Gene of the month: TLE 1.
Title: Gene of the month: TLE 1.
SATB2 and TLE1 Expression in BCOR-CCNB3 (Ewing-like) Sarcoma, Mimicking Small Cell Osteosarcoma and Poorly Differentiated Synovial Sarcoma.
Title: SATB2 and TLE1 Expression in BCOR-CCNB3 (Ewing-like) Sarcoma, Mimicking Small Cell Osteosarcoma and Poorly Differentiated Synovial Sarcoma.
TLE1 expression fails to distinguish between synovial sarcoma, atypical fibroxanthoma, and dermatofibrosarcoma protuberans.
Title: TLE1 expression fails to distinguish between synovial sarcoma, atypical fibroxanthoma, and dermatofibrosarcoma protuberans.
The combined use of H3K27 trimethylation and TLE1 can provide additional diagnostic value for malignant peripheral nerve sheath tumor and synovial sarcoma.
Title: The combined use of H3K27 trimethylation and TLE1 can provide additional diagnostic value for malignant peripheral nerve sheath tumor and synovial sarcoma.

Submit: New GeneRIF Correction See all GeneRIFs (55)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. EBI GWAS Catalog EBI GWAS CatalogPubMed
Multiple loci influencing hippocampal degeneration identified by genome scan. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vif	vif	HIV-1 Vif upregulates the expression of transducin-like enhancer of split 1 homolog protein (TLE1) in Vif-expression T cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WIAF-2165 (e-PCR)
- UniSTS:27164

MARC_6203-6204:992007078:5 (e-PCR)
- UniSTS:231207

SHGC-68608 (e-PCR)
- UniSTS:100652

D8S2282 (e-PCR)
- UniSTS:473910

WI-11585 (e-PCR)
- UniSTS:76868

L18426 (e-PCR)
- UniSTS:34648

SHGC-57364 (e-PCR)
- UniSTS:67674

G60053 (e-PCR)
- UniSTS:137315

G44334 (e-PCR)
- UniSTS:95121

A001X07 (e-PCR)
- UniSTS:15516

D1S2077E (e-PCR)
- UniSTS:151716

WI-12646 (e-PCR)
- UniSTS:951

GDB:335751 (e-PCR)
- UniSTS:156601

L17971 (e-PCR)
- UniSTS:43966

TLE1_1890 (e-PCR)
- UniSTS:281058

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in animal organ morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of anoikis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of beta-catenin-TCF complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transducin-like enhancer protein 1

Names: enhancer of split groucho-like protein 1; transducin like enhancer of split 1; transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001303103.2 → NP_001290032.1 transducin-like enhancer protein 1 isoform 1

See identical proteins and their annotated locations for NP_001290032.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AB209854, AL353682, AL365190, BC000228, BC010100, DB211613

UniProtKB/TrEMBL

B4DEF9

Conserved Domains (4) summary

PHA03247
Location:329 → 486

PHA03247; large tegument protein UL36; Provisional

cd00200
Location:493 → 777

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:497 → 536

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 143

TLE_N; Groucho/TLE N-terminal Q-rich domain
NM_001303104.2 → NP_001290033.1 transducin-like enhancer protein 1 isoform 3

See identical proteins and their annotated locations for NP_001290033.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses two alternate in-frame splice sites compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

Source sequence(s)

AB209854, AK293606, AL353682, AL365190, BC010100, DB211613

UniProtKB/TrEMBL

B4DEF9

Conserved Domains (3) summary

cd00200
Location:468 → 752

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:472 → 511

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 133

TLE_N; Groucho/TLE N-terminal Q-rich domain
NM_005077.5 → NP_005068.2 transducin-like enhancer protein 1 isoform 2

See identical proteins and their annotated locations for NP_005068.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AB209854, AL365190, BC010100, DB211613

Consensus CDS

CCDS6661.1

UniProtKB/Swiss-Prot

A8K495, Q04724, Q5T3G4, Q969V9

UniProtKB/TrEMBL

B4DEF9

Related

ENSP00000365682.3, ENST00000376499.8

Conserved Domains (4) summary

PHA03247
Location:319 → 476

PHA03247; large tegument protein UL36; Provisional

cd00200
Location:483 → 767

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:487 → 526

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 133

TLE_N; Groucho/TLE N-terminal Q-rich domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000009.12 Reference GRCh38.p14 Primary Assembly

Range

81583683..81689547 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006717259.5 → XP_006717322.1 transducin-like enhancer protein 1 isoform X8

UniProtKB/TrEMBL

B4DEF9

Conserved Domains (4) summary

COG2319
Location:464 → 756

WD40; WD40 repeat [General function prediction only]

cd00200
Location:471 → 755

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam03920
Location:1 → 77

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:475 → 514

7WD40; WD40 repeat [structural motif]
XM_047423817.1 → XP_047279773.1 transducin-like enhancer protein 1 isoform X17
XM_005252163.3 → XP_005252220.1 transducin-like enhancer protein 1 isoform X16

See identical proteins and their annotated locations for XP_005252220.1

UniProtKB/TrEMBL

B4DEF9

Conserved Domains (4) summary

PHA03247
Location:245 → 402

PHA03247; large tegument protein UL36; Provisional

cd00200
Location:409 → 693

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:413 → 452

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 128

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_047423814.1 → XP_047279770.1 transducin-like enhancer protein 1 isoform X12
XM_005252162.2 → XP_005252219.1 transducin-like enhancer protein 1 isoform X11

UniProtKB/TrEMBL

B4DEF9

Conserved Domains (4) summary

COG2319
Location:436 → 728

WD40; WD40 repeat [General function prediction only]

cd00200
Location:443 → 727

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam03920
Location:1 → 124

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:447 → 486

7WD40; WD40 repeat [structural motif]
XM_006717263.2 → XP_006717326.1 transducin-like enhancer protein 1 isoform X20

See identical proteins and their annotated locations for XP_006717326.1

UniProtKB/TrEMBL

B4DEF9

Conserved Domains (3) summary

cd00200
Location:481 → 765

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:485 → 524

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 132

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_011518951.3 → XP_011517253.1 transducin-like enhancer protein 1 isoform X7

See identical proteins and their annotated locations for XP_011517253.1

UniProtKB/TrEMBL

B4DEF9

Conserved Domains (4) summary

PHA03247
Location:318 → 475

PHA03247; large tegument protein UL36; Provisional

cd00200
Location:482 → 766

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:486 → 525

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 132

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_005252154.2 → XP_005252211.1 transducin-like enhancer protein 1 isoform X5

UniProtKB/TrEMBL

B4DEF9

Conserved Domains (4) summary

COG2319
Location:509 → 801

WD40; WD40 repeat [General function prediction only]

cd00200
Location:516 → 800

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam03920
Location:1 → 132

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:520 → 559

7WD40; WD40 repeat [structural motif]
XM_006717262.2 → XP_006717325.1 transducin-like enhancer protein 1 isoform X19

See identical proteins and their annotated locations for XP_006717325.1

UniProtKB/TrEMBL

B4DEF9

Conserved Domains (3) summary

cd00200
Location:482 → 766

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:486 → 525

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 133

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_005252153.2 → XP_005252210.1 transducin-like enhancer protein 1 isoform X4

UniProtKB/TrEMBL

B4DEF9

Conserved Domains (4) summary

COG2319
Location:510 → 802

WD40; WD40 repeat [General function prediction only]

cd00200
Location:517 → 801

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam03920
Location:1 → 133

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:521 → 560

7WD40; WD40 repeat [structural motif]
XM_047423816.1 → XP_047279772.1 transducin-like enhancer protein 1 isoform X14
XM_047423815.1 → XP_047279771.1 transducin-like enhancer protein 1 isoform X13

Conserved Domains (4) summary

PHA03247
Location:255 → 412

PHA03247; large tegument protein UL36; Provisional

cd00200
Location:419 → 703

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:423 → 462

7WD40; WD40 repeat [structural motif]

pfam03920
Location:18 → 124

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_047423813.1 → XP_047279769.1 transducin-like enhancer protein 1 isoform X10
XM_006717260.2 → XP_006717323.1 transducin-like enhancer protein 1 isoform X9

UniProtKB/TrEMBL

B4DEF9

Conserved Domains (4) summary

COG2319
Location:446 → 738

WD40; WD40 repeat [General function prediction only]

cd00200
Location:453 → 737

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam03920
Location:1 → 124

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:457 → 496

7WD40; WD40 repeat [structural motif]
XM_006717258.2 → XP_006717321.1 transducin-like enhancer protein 1 isoform X3

UniProtKB/TrEMBL

B4DEF9

Conserved Domains (4) summary

COG2319
Location:519 → 811

WD40; WD40 repeat [General function prediction only]

cd00200
Location:526 → 810

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam03920
Location:1 → 142

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:530 → 569

7WD40; WD40 repeat [structural motif]
XM_005252156.4 → XP_005252213.1 transducin-like enhancer protein 1 isoform X6

See identical proteins and their annotated locations for XP_005252213.1

UniProtKB/TrEMBL

B4DEF9

Conserved Domains (3) summary

cd00200
Location:492 → 776

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:496 → 535

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 143

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_005252152.2 → XP_005252209.1 transducin-like enhancer protein 1 isoform X2

UniProtKB/TrEMBL

B4DEF9

Conserved Domains (4) summary

COG2319
Location:519 → 811

WD40; WD40 repeat [General function prediction only]

cd00200
Location:526 → 810

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam03920
Location:1 → 143

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:530 → 569

7WD40; WD40 repeat [structural motif]
XM_005252151.2 → XP_005252208.1 transducin-like enhancer protein 1 isoform X1

UniProtKB/TrEMBL

B4DEF9

Conserved Domains (4) summary

COG2319
Location:520 → 812

WD40; WD40 repeat [General function prediction only]

cd00200
Location:527 → 811

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam03920
Location:1 → 143

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:531 → 570

7WD40; WD40 repeat [structural motif]
XM_006717261.3 → XP_006717324.1 transducin-like enhancer protein 1 isoform X15

UniProtKB/TrEMBL

B4DEF9

Conserved Domains (3) summary

COG2319
Location:411 → 697

WD40; WD40 repeat [General function prediction only]

sd00039
Location:416 → 455

7WD40; WD40 repeat [structural motif]

cl02567
Location:412 → 696

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_047423818.1 → XP_047279774.1 transducin-like enhancer protein 1 isoform X18