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Trak2 trafficking protein, kinesin binding 2 [ Mus musculus (house mouse) ]

Gene ID: 70827, updated on 2-Nov-2024

Summary

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Official Symbol
Trak2provided by MGI
Official Full Name
trafficking protein, kinesin binding 2provided by MGI
Primary source
MGI:MGI:1918077
See related
Ensembl:ENSMUSG00000026028 AllianceGenome:MGI:1918077
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GRIF1; OIP98; CALS-C; GRIF-1; Als2cr3; mKIAA0549; 2900022D04Rik; 4733401O11Rik
Summary
Predicted to enable several functions, including GABA receptor binding activity; TPR domain binding activity; and cytoskeletal protein binding activity. Predicted to be involved in several processes, including dendrite morphogenesis; negative regulation of axonogenesis; and organelle transport along microtubule. Predicted to be located in several cellular components, including axonal growth cone; early endosome; and neuronal cell body. Predicted to be active in cytoplasmic vesicle; dendrite; and mitochondrion. Is expressed in several structures, including brain; genitourinary system; liver; retina nuclear layer; and spleen. Orthologous to human TRAK2 (trafficking kinesin protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in liver E14 (RPKM 25.9), liver E14.5 (RPKM 25.0) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Trak2 in Genome Data Viewer
Location:
1 C1.3; 1 29.2 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (58939608..59013509, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (58900449..58974345, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr1:58854474-58854775 Neighboring gene caspase 8 Neighboring gene predicted gene 28802 Neighboring gene STARR-seq mESC enhancer starr_01024 Neighboring gene STARR-seq mESC enhancer starr_01025 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:59013204-59013435 Neighboring gene STARR-seq mESC enhancer starr_01027 Neighboring gene STARR-positive B cell enhancer ABC_E982 Neighboring gene STE20-related kinase adaptor beta Neighboring gene C2 calcium dependent domain containing 6 Neighboring gene STARR-seq mESC enhancer starr_01029 Neighboring gene predicted gene 29018 Neighboring gene predicted gene, 25502

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and dendrites. van Spronsen M, et al. Neuron, 2013 Feb 6. PMID 23395375
  2. The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2. López-Doménech G, et al. Nat Commun, 2012 May 8. PMID 22569362
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
  4. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro 1/2 and Trak2.
    Title: The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GABA receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GABA receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables TPR domain binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables kinesin binding ISO
Inferred from Sequence Orthology
more info
  
enables myosin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in anterograde axonal transport of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in dendritic transport of mitochondrion ISO
Inferred from Sequence Orthology
more info
  
involved_in endosome to lysosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrion distribution IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of axonogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle transport along microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in axonal growth cone ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
trafficking kinesin-binding protein 2
Names
amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172406.3 → NP_765994.2  trafficking kinesin-binding protein 2

    See identical proteins and their annotated locations for NP_765994.2

    Status: VALIDATED

    Source sequence(s)
    AK036650, AK053848, BC060681, CJ116609
    Consensus CDS
    CCDS14980.1
    UniProtKB/TrEMBL
    Q6P9N8, Q8BZ57
    Related
    ENSMUSP00000027186.6, ENSMUST00000027186.12
    Conserved Domains (2) summary
    pfam04849
    Location:50 → 353
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:414 → 565
    Milton; Kinesin associated protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    58939608..59013509 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153623.1 → XP_036009516.1  trafficking kinesin-binding protein 2 isoform X1

    UniProtKB/TrEMBL
    Q8BZ57
    Conserved Domains (2) summary
    pfam04849
    Location:50 → 372
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:433 → 584
    Milton; Kinesin associated protein

  2. XM_006496280.4 → XP_006496343.1  trafficking kinesin-binding protein 2 isoform X4

    UniProtKB/TrEMBL
    Q8BZ57
    Conserved Domains (2) summary
    pfam04849
    Location:50 → 353
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:414 → 565
    Milton; Kinesin associated protein

  3. XM_036153625.1 → XP_036009518.1  trafficking kinesin-binding protein 2 isoform X1

    UniProtKB/TrEMBL
    Q8BZ57
    Conserved Domains (2) summary
    pfam04849
    Location:50 → 372
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:433 → 584
    Milton; Kinesin associated protein

  4. XM_036153639.1 → XP_036009532.1  trafficking kinesin-binding protein 2 isoform X7

    UniProtKB/TrEMBL
    Q8BZ57
    Conserved Domains (2) summary
    pfam04849
    Location:24 → 288
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:349 → 500
    Milton; Kinesin associated protein

  5. XM_006496281.5 → XP_006496344.1  trafficking kinesin-binding protein 2 isoform X6

    UniProtKB/TrEMBL
    Q8BZ57
    Conserved Domains (3) summary
    cl29994
    Location:694 → 734
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    pfam04849
    Location:24 → 288
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:349 → 500
    Milton; Kinesin associated protein

  6. XM_036153638.1 → XP_036009531.1  trafficking kinesin-binding protein 2 isoform X5

    UniProtKB/TrEMBL
    Q8BZ57
    Conserved Domains (2) summary
    pfam04849
    Location:24 → 307
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:368 → 519
    Milton; Kinesin associated protein

  7. XM_036153627.1 → XP_036009520.1  trafficking kinesin-binding protein 2 isoform X2

    UniProtKB/TrEMBL
    Q8BZ57
    Conserved Domains (2) summary
    pfam04849
    Location:50 → 372
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:433 → 584
    Milton; Kinesin associated protein

  8. XM_036153640.1 → XP_036009533.1  trafficking kinesin-binding protein 2 isoform X8

    Conserved Domains (2) summary
    pfam04849
    Location:50 → 372
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:433 → 584
    Milton; Kinesin associated protein

  9. XM_030242947.2 → XP_030098807.1  trafficking kinesin-binding protein 2 isoform X3

    UniProtKB/TrEMBL
    Q6P9N8, Q8BZ57
    Conserved Domains (2) summary
    pfam04849
    Location:50 → 353
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:414 → 565
    Milton; Kinesin associated protein

  10. XM_036153630.1 → XP_036009523.1  trafficking kinesin-binding protein 2 isoform X3

    UniProtKB/TrEMBL
    Q6P9N8, Q8BZ57
    Conserved Domains (2) summary
    pfam04849
    Location:50 → 353
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:414 → 565
    Milton; Kinesin associated protein

  11. XM_036153641.1 → XP_036009534.1  trafficking kinesin-binding protein 2 isoform X9

    UniProtKB/TrEMBL
    G3UYW9
    Related
    ENSMUSP00000134253.2, ENSMUST00000174120.2
    Conserved Domains (2) summary
    pfam04849
    Location:50 → 353
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:414 → 565
    Milton; Kinesin associated protein

  12. XM_006496282.4 → XP_006496345.1  trafficking kinesin-binding protein 2 isoform X9

    UniProtKB/TrEMBL
    G3UYW9
    Conserved Domains (2) summary
    pfam04849
    Location:50 → 353
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:414 → 565
    Milton; Kinesin associated protein

  13. XM_036153642.1 → XP_036009535.1  trafficking kinesin-binding protein 2 isoform X10

    Conserved Domains (2) summary
    pfam04849
    Location:24 → 288
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:349 → 500
    Milton; Kinesin associated protein
Nucleotide Protein Strain
Heading Accession and Version

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