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Cep192 centrosomal protein 192 [ Mus musculus (house mouse) ]

Gene ID: 70799, updated on 2-Nov-2024

Summary

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Official Symbol
Cep192provided by MGI
Official Full Name
centrosomal protein 192provided by MGI
Primary source
MGI:MGI:1918049
See related
Ensembl:ENSMUSG00000024542 AllianceGenome:MGI:1918049
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4631422C13Rik; D430014P18Rik
Summary
Predicted to enable phosphatase binding activity and protein kinase binding activity. Acts upstream of or within response to bacterium. Located in cytoplasm and pericentriolar material. Is expressed in cerebral cortex ventricular layer and meninges. Orthologous to human CEP192 (centrosomal protein 192). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 7.7), limb E14.5 (RPKM 5.8) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Cep192 in Genome Data Viewer
Location:
18 E1- E2; 18 40.11 cM
Exon count:
48
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (67933124..68018241)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (67800054..67885170)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930549G23 gene Neighboring gene STARR-positive B cell enhancer ABC_E11001 Neighboring gene STARR-positive B cell enhancer ABC_E1518 Neighboring gene predicted gene, 26910 Neighboring gene STARR-positive B cell enhancer ABC_E11662 Neighboring gene SEH1-like (S. cerevisiae Neighboring gene STARR-seq mESC enhancer starr_44916 Neighboring gene STARR-seq mESC enhancer starr_44917 Neighboring gene STARR-seq mESC enhancer starr_44919 Neighboring gene tubulin, alpha 1B pseudogene Neighboring gene STARR-seq mESC enhancer starr_44922 Neighboring gene low density lipoprotein receptor class A domain containing 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:68126707-68126976 Neighboring gene predicted gene, 52336

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mosaic variegated aneuploidy syndrome with tetraploid, and predisposition to male infertility triggered by mutant CEP192. Guo J, et al. HGG Adv, 2024 Jan 11. PMID 37981762, Free PMC Article
  2. Distinct roles of Cep192 and Cep152 in acentriolar MTOCs and spindle formation during mouse oocyte maturation. Lee IW, et al. FASEB J, 2018 Feb. PMID 28970258
  3. CIP2A acts as a scaffold for CEP192-mediated microtubule organizing center assembly by recruiting Plk1 and aurora A during meiotic maturation. Wang H, et al. Development, 2017 Oct 15. PMID 28935709
  4. The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis. Zhu F, et al. Curr Biol, 2008 Jan 22. PMID 18207742
  5. A Human Hereditary Cardiomyopathy Shares a Genetic Substrate With Bicuspid Aortic Valve. Siguero-Álvarez M, et al. Circulation, 2023 Jan 3. PMID 36325906

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mosaic variegated aneuploidy syndrome with tetraploid, and predisposition to male infertility triggered by mutant CEP192.
    Title: Mosaic variegated aneuploidy syndrome with tetraploid, and predisposition to male infertility triggered by mutant CEP192.
  2. results demonstrate the different roles of Cep192 and Cep152 in MTOC remodeling and a novel regulatory mechanism during meiotic spindle formation in mouse oocytes.
    Title: Distinct roles of Cep192 and Cep152 in acentriolar MTOCs and spindle formation during mouse oocyte maturation.
  3. CIP2A acts as a scaffold for CEP192-mediated microtubule organizing center assembly by recruiting Plk1 and aurora A during meiotic maturation in mouse oocytes
    Title: CIP2A acts as a scaffold for CEP192-mediated microtubule organizing center assembly by recruiting Plk1 and aurora A during meiotic maturation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in centrosome cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in centrosome-templated microtubule nucleation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within microtubule nucleation ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mitotic spindle assembly checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in protein localization to centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to centrosome ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of centriole replication ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within regulation of centrosome cycle ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within regulation of establishment of protein localization ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in pericentriolar material IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in pericentriolar material IDA
Inferred from Direct Assay
more info
 PubMed 
located_in procentriole ISO
Inferred from Sequence Orthology
more info
  
part_of procentriole replication complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
centrosomal protein of 192 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027556.1 → NP_081832.1  centrosomal protein of 192 kDa

    Status: VALIDATED

    Source sequence(s)
    AC127236, AK052420, AK158414, BC064462, BE982606, CD538408, CK391255, CK639048, CO045915
    Consensus CDS
    CCDS50313.1
    UniProtKB/TrEMBL
    E9Q4Y4
    Related
    ENSMUSP00000025425.6, ENSMUST00000025425.7
    Conserved Domains (1) summary
    cl13764
    Location:1636 → 1703
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    67933124..68018241
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526241.3 → XP_006526304.1  centrosomal protein of 192 kDa isoform X1

    See identical proteins and their annotated locations for XP_006526304.1

    Conserved Domains (2) summary
    pfam08626
    Location:1651 → 1772
    TRAPPC9-Trs120; Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit
    cl13764
    Location:1636 → 1703
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

  2. XM_011247001.4 → XP_011245303.1  centrosomal protein of 192 kDa isoform X5

    Conserved Domains (2) summary
    pfam08626
    Location:1651 → 1772
    TRAPPC9-Trs120; Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit
    cl13764
    Location:1636 → 1703
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

  3. XM_006526243.4 → XP_006526306.1  centrosomal protein of 192 kDa isoform X2

    Conserved Domains (2) summary
    pfam08626
    Location:1608 → 1729
    TRAPPC9-Trs120; Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit
    cl13764
    Location:1593 → 1660
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

  4. XM_006526242.3 → XP_006526305.1  centrosomal protein of 192 kDa isoform X1

    See identical proteins and their annotated locations for XP_006526305.1

    Conserved Domains (2) summary
    pfam08626
    Location:1651 → 1772
    TRAPPC9-Trs120; Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit
    cl13764
    Location:1636 → 1703
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

  5. XM_036161275.1 → XP_036017168.1  centrosomal protein of 192 kDa isoform X3

    Conserved Domains (1) summary
    cl13764
    Location:1406 → 1473
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

  6. XM_011247000.4 → XP_011245302.1  centrosomal protein of 192 kDa isoform X4

    Conserved Domains (2) summary
    pfam08626
    Location:1019 → 1140
    TRAPPC9-Trs120; Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit
    cl13764
    Location:1004 → 1071
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
Nucleotide Protein Strain
Heading Accession and Version

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