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Kynu kynureninase [ Mus musculus (house mouse) ]

Gene ID: 70789, updated on 2-Nov-2024

Summary

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Official Symbol
Kynuprovided by MGI
Official Full Name
kynureninaseprovided by MGI
Primary source
MGI:MGI:1918039
See related
Ensembl:ENSMUSG00000026866 AllianceGenome:MGI:1918039
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4432411A05Rik
Summary
Predicted to enable kynureninase activity; protein homodimerization activity; and pyridoxal phosphate binding activity. Predicted to be involved in several processes, including aromatic amino acid metabolic process; quinolinate biosynthetic process; and response to type II interferon. Located in mitochondrion. Human ortholog(s) of this gene implicated in hydroxykynureninuria. Orthologous to human KYNU (kynureninase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver adult (RPKM 9.9), liver E18 (RPKM 4.5) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Kynu in Genome Data Viewer
Location:
2 B; 2 25.64 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (43445270..43572734)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (43555258..43683048)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 54112 Neighboring gene STARR-seq mESC enhancer starr_04383 Neighboring gene STARR-seq mESC enhancer starr_04384 Neighboring gene STARR-positive B cell enhancer ABC_E11131 Neighboring gene STARR-positive B cell enhancer mm9_chr2:43441000-43441301 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr2:43478445-43478746 Neighboring gene STARR-seq mESC enhancer starr_04386 Neighboring gene STARR-positive B cell enhancer ABC_E4451 Neighboring gene STARR-seq mESC enhancer starr_04387 Neighboring gene STARR-positive B cell enhancer ABC_E9513 Neighboring gene STARR-seq mESC enhancer starr_04388 Neighboring gene STARR-positive B cell enhancer ABC_E636 Neighboring gene predicted gene, 30374 Neighboring gene Rho GTPase activating protein 15 Neighboring gene predicted gene, 39804

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Quinolinate promotes macrophage-induced immune tolerance in glioblastoma through the NMDAR/PPARγ signaling axis. Kesarwani P, et al. Nat Commun, 2023 Mar 16. PMID 36927729, Free PMC Article
  2. Kynureninase contributes to the pathogenesis of psoriasis through pro-inflammatory effect. Wang M, et al. J Cell Physiol, 2022 Jan. PMID 34553380
  3. De novo NAD(+) synthesis contributes to CD8(+) T cell metabolic fitness and antitumor function. Wan J, et al. Cell Rep, 2023 Dec 26. PMID 38041812
  4. Gene expression of enzymes for tryptophan degradation pathway is upregulated in the skin lesions of patients with atopic dermatitis or psoriasis. Ito M, et al. J Dermatol Sci, 2004 Dec. PMID 15541637
  5. NAD Deficiency, Congenital Malformations, and Niacin Supplementation. Shi H, et al. N Engl J Med, 2017 Aug 10. PMID 28792876

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kynureninase contributes to the pathogenesis of psoriasis through pro-inflammatory effect.
    Title: Kynureninase contributes to the pathogenesis of psoriasis through pro-inflammatory effect.
  2. Levels of mRNA for IDO (indoleamine 2,3-dioxygenase) and kynureninase, enzymes constituting the tryptophan degradation pathway, were found to be upregulated in the skin lesions of atopic dermatitis or psoriasis
    Title: Gene expression of enzymes for tryptophan degradation pathway is upregulated in the skin lesions of patients with atopic dermatitis or psoriasis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables kynureninase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kynureninase activity IEA
Inferred from Electronic Annotation
more info
  
enables kynureninase activity ISO
Inferred from Sequence Orthology
more info
  
enables kynureninase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphate binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in 'de novo' NAD biosynthetic process from tryptophan IEA
Inferred from Electronic Annotation
more info
  
involved_in L-kynurenine catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in NAD biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in NAD biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in anthranilate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anthranilate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in anthranilate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in quinolinate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in quinolinate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to type II interferon IEA
Inferred from Electronic Annotation
more info
  
involved_in response to type II interferon ISO
Inferred from Sequence Orthology
more info
  
involved_in response to vitamin B6 IEA
Inferred from Electronic Annotation
more info
  
involved_in response to vitamin B6 ISO
Inferred from Sequence Orthology
more info
  
involved_in tryptophan catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in tryptophan catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in tryptophan catabolic process to acetyl-CoA ISO
Inferred from Sequence Orthology
more info
  
involved_in tryptophan catabolic process to kynurenine IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kynureninase
Names
L-kynurenine hydrolase
NP_001276522.1
NP_001276523.1
NP_001385605.1
NP_081828.2
XP_011237480.1
XP_011237481.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289593.1 → NP_001276522.1  kynureninase isoform 2

    See identical proteins and their annotated locations for NP_001276522.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a 3' terminal exon which extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK050024, AK149423, AL845160
    Consensus CDS
    CCDS79792.1
    UniProtKB/TrEMBL
    F7BY26, Q6NSV5
    Related
    ENSMUSP00000108445.3, ENSMUST00000112826.8
    Conserved Domains (2) summary
    TIGR01814
    Location:31 → 426
    kynureninase; kynureninase
    cl18945
    Location:25 → 426
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

  2. NM_001289594.1 → NP_001276523.1  kynureninase isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK050024, AK149423, AL845336
    Consensus CDS
    CCDS79791.1
    UniProtKB/TrEMBL
    A2ARD7, Q8R0F7
    Related
    ENSMUSP00000061775.8, ENSMUST00000050511.7
    Conserved Domains (1) summary
    cl18945
    Location:25 → 303
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

  3. NM_001398676.1 → NP_001385605.1  kynureninase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL845160, AL845336
    UniProtKB/Swiss-Prot
    Q9CXF0
    Related
    ENSMUSP00000159520.1, ENSMUST00000240759.1
    Conserved Domains (1) summary
    TIGR01814
    Location:30 → 459
    kynureninase

  4. NM_027552.3 → NP_081828.2  kynureninase isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL845160, AL845336
    Consensus CDS
    CCDS16018.1
    UniProtKB/Swiss-Prot
    Q9CXF0
    Related
    ENSMUSP00000028223.4, ENSMUST00000028223.10
    Conserved Domains (1) summary
    TIGR01814
    Location:30 → 459
    kynureninase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    43445270..43572734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239179.3 → XP_011237481.1  kynureninase isoform X3

    UniProtKB/TrEMBL
    A2ARD6
    Conserved Domains (1) summary
    TIGR01814
    Location:31 → 427
    kynureninase

  2. XM_011239178.1 → XP_011237480.1  kynureninase isoform X2

    UniProtKB/TrEMBL
    A2ARD6
    Conserved Domains (1) summary
    TIGR01814
    Location:31 → 436
    kynureninase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CXF0.3 GenPept UniProtKB/Swiss-Prot:Q9CXF0

Gene LinkOut

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