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Adgra3 adhesion G protein-coupled receptor A3 [ Mus musculus (house mouse) ]

Gene ID: 70693, updated on 18-Sep-2024

Summary

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Official Symbol
Adgra3provided by MGI
Official Full Name
adhesion G protein-coupled receptor A3provided by MGI
Primary source
MGI:MGI:1917943
See related
Ensembl:ENSMUSG00000029090 AllianceGenome:MGI:1917943
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gpr125; Tem5-like; 3830613O22Rik
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in cell surface receptor signaling pathway. Predicted to act upstream of or within signal transduction. Located in external side of plasma membrane. Is expressed in several structures, including central nervous system; craniocervical region bone; limb; metanephros; and sensory organ. Orthologous to human ADGRA3 (adhesion G protein-coupled receptor A3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 32.5), ovary adult (RPKM 24.3) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Adgra3 in Genome Data Viewer
Location:
5 B3; 5 26.85 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (50117293..50216338, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (49959951..50058996, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13035 Neighboring gene predicted gene, 40299 Neighboring gene STARR-seq mESC enhancer starr_13036 Neighboring gene STARR-seq mESC enhancer starr_13037 Neighboring gene STARR-seq mESC enhancer starr_13038 Neighboring gene STARR-seq mESC enhancer starr_13039 Neighboring gene cytoskeleton associated protein 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_13040 Neighboring gene predicted gene, 36702 Neighboring gene STARR-seq mESC enhancer starr_13041 Neighboring gene predicted gene, 40300

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of Adgra3 causes obstructive azoospermia with high penetrance in male mice. Nybo ML, et al. FASEB J, 2023 Feb. PMID 36688818, Free PMC Article
  2. The Adhesion GPCR GPR125 is specifically expressed in the choroid plexus and is upregulated following brain injury. Pickering C, et al. BMC Neurosci, 2008 Oct 3. PMID 18834514, Free PMC Article
  3. Involvement of Gpr125 in the myeloid sarcoma formation induced by cooperating MLL/AF10(OM-LZ) and oncogenic KRAS in a mouse bone marrow transplantation model. Fu JF, et al. Int J Cancer, 2013 Oct 15. PMID 23564351
  4. Gpr125 Marks Distinct Cochlear Cell Types and Is Dispensable for Cochlear Development and Hearing. Sun H, et al. Front Cell Dev Biol, 2021. PMID 34395423, Free PMC Article
  5. Gpr125 is a unifying hallmark of multiple mammary progenitors coupled to tumor latency. Spina E, et al. Nat Commun, 2022 Mar 17. PMID 35302059, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of Adgra3 causes obstructive azoospermia with high penetrance in male mice.
    Title: Loss of Adgra3 causes obstructive azoospermia with high penetrance in male mice.
  2. upregulation of Gpr125 by cooperating MLL/AF10(OM-LZ) and KRASG12C promoted cell adhesion and contributed to the myeloid sarcoma formation.
    Title: Involvement of Gpr125 in the myeloid sarcoma formation induced by cooperating MLL/AF10(OM-LZ) and oncogenic KRAS in a mouse bone marrow transplantation model.
  3. Data show that GPR125 is specifically expressed in cells of the choroid plexus and is upregulated following traumatic brain injury.
    Title: The Adhesion GPCR GPR125 is specifically expressed in the choroid plexus and is upregulated following brain injury.
  4. GPR125+ multipotent adult stem cells generated derivatives of the three germ layers and contributed to chimaeric embryos, with concomitant downregulation of GPR125 during differentiation into GPR125- cells
    Title: Generation of functional multipotent adult stem cells from GPR125+ germline progenitors.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
adhesion G protein-coupled receptor A3
Names
G protein coupled receptor Gpr125
G protein-coupled receptor 125
probable G-protein coupled receptor 125

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133911.1 → NP_598672.1  adhesion G protein-coupled receptor A3 precursor

    See identical proteins and their annotated locations for NP_598672.1

    Status: VALIDATED

    Source sequence(s)
    AK028929, AV238761, BC052391
    Consensus CDS
    CCDS51500.1
    UniProtKB/Swiss-Prot
    E9QK56, Q6PE67, Q7TT36, Q8VE71
    Related
    ENSMUSP00000030971.6, ENSMUST00000030971.7
    Conserved Domains (10) summary
    smart00082
    Location:178 → 212
    LRRCT; Leucine rich repeat C-terminal domain
    smart00410
    Location:238 → 330
    IG_like; Immunoglobulin like
    cd00116
    Location:73 → 155
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:72 → 95
    LRR_1; leucine-rich repeat [structural motif]
    pfam01825
    Location:688 → 732
    GPS; GPCR proteolysis site, GPS, motif
    pfam02793
    Location:352 → 405
    HRM; Hormone receptor domain
    pfam12799
    Location:119 → 158
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:74 → 130
    LRR_8; Leucine rich repeat
    cl11960
    Location:242 → 326
    Ig; Immunoglobulin domain
    cl21561
    Location:751 → 934
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    50117293..50216338 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TT36.3 GenPept UniProtKB/Swiss-Prot:Q7TT36

Gene LinkOut

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Chemical Information
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