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Pak4 p21 (RAC1) activated kinase 4 [ Mus musculus (house mouse) ]

Gene ID: 70584, updated on 2-Nov-2024

Summary

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Official Symbol
Pak4provided by MGI
Official Full Name
p21 (RAC1) activated kinase 4provided by MGI
Primary source
MGI:MGI:1917834
See related
Ensembl:ENSMUSG00000030602 AllianceGenome:MGI:1917834
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1142; 5730488L07Rik
Summary
Enables protein kinase activity. Acts upstream of or within cellular response to organic cyclic compound and dendritic spine development. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human PAK4 (p21 (RAC1) activated kinase 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in colon adult (RPKM 40.7), duodenum adult (RPKM 33.4) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Pak4 in Genome Data Viewer
Location:
7 A3- B1; 7 16.84 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28258244..28297609, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (28558819..28598184, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29342572-29342755 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29342797-29343021 Neighboring gene predicted gene, 38977 Neighboring gene microRNA 7049 Neighboring gene STARR-seq mESC enhancer starr_18428 Neighboring gene acid phosphatase 7, tartrate resistant Neighboring gene STARR-seq mESC enhancer starr_18429 Neighboring gene STARR-seq mESC enhancer starr_18430 Neighboring gene STARR-seq mESC enhancer starr_18432 Neighboring gene STARR-seq mESC enhancer starr_18434 Neighboring gene F-box protein 27

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Pak4 induces premature senescence via a pathway requiring p16INK4/p19ARF and mitogen-activated protein kinase signaling. Cammarano MS, et al. Mol Cell Biol, 2005 Nov. PMID 16227603, Free PMC Article
  2. Pdx1-Cre-driven conditional gene depletion suggests PAK4 as dispensable for mouse pancreas development. Zhao M, et al. Sci Rep, 2017 Aug 1. PMID 28765528, Free PMC Article
  3. PAK4 crystal structures suggest unusual kinase conformational movements. Zhang EY, et al. Biochim Biophys Acta Proteins Proteom, 2018 Feb. PMID 28993291, Free PMC Article
  4. Normal mammary gland development after MMTV-Cre mediated conditional PAK4 gene depletion. Rabieifar P, et al. Sci Rep, 2019 Oct 8. PMID 31594963, Free PMC Article
  5. Repositioning Potential of PAK4 to Osteoclastic Bone Resorption. Choi SW, et al. J Bone Miner Res, 2015 Aug. PMID 25640698

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PAK4 phosphorylates and inhibits AMPKalpha to control glucose uptake.
    Title: PAK4 phosphorylates and inhibits AMPKα to control glucose uptake.
  2. Inhibition of P21-activated kinases 1 and 4 synergistically suppresses the growth of pancreatic cancer by stimulating anti-tumour immunity.
    Title: Inhibition of P21-activated kinases 1 and 4 synergistically suppresses the growth of pancreatic cancer by stimulating anti-tumour immunity.
  3. p21-activated kinase 4 counteracts PKA-dependent lipolysis by phosphorylating FABP4 and HSL.
    Title: p21-activated kinase 4 counteracts PKA-dependent lipolysis by phosphorylating FABP4 and HSL.
  4. p21-activated kinase 4 suppresses fatty acid beta-oxidation and ketogenesis by phosphorylating NCoR1.
    Title: p21-activated kinase 4 suppresses fatty acid β-oxidation and ketogenesis by phosphorylating NCoR1.
  5. P21-Activated Kinase 4 Pak4 Maintains Embryonic Stem Cell Pluripotency via Akt Activation.
    Title: P21-Activated Kinase 4 Pak4 Maintains Embryonic Stem Cell Pluripotency via Akt Activation.
  6. p21-activated kinase 4 inhibition protects against liver ischemia/reperfusion injury: Role of nuclear factor erythroid 2-related factor 2 phosphorylation.
    Title: p21-activated kinase 4 inhibition protects against liver ischemia/reperfusion injury: Role of nuclear factor erythroid 2-related factor 2 phosphorylation.
  7. p21-activated kinase 4 controls the aggregation of alpha-synuclein by reducing the monomeric and aggregated forms of alpha-synuclein: involvement of the E3 ubiquitin ligase NEDD4-1.
    Title: p21-activated kinase 4 controls the aggregation of α-synuclein by reducing the monomeric and aggregated forms of α-synuclein: involvement of the E3 ubiquitin ligase NEDD4-1.
  8. PAK4 inhibition improves PD-1 blockade immunotherapy.
    Title: PAK4 inhibition improves PD-1 blockade immunotherapy.
  9. Targeting PAK4 to reprogram the vascular microenvironment and improve CAR-T immunotherapy for glioblastoma.
    Title: Targeting PAK4 to reprogram the vascular microenvironment and improve CAR-T immunotherapy for glioblastoma.
  10. p21-activated kinase 4 phosphorylates peroxisome proliferator-activated receptor Upsilon and suppresses skeletal muscle regeneration.
    Title: p21-activated kinase 4 phosphorylates peroxisome proliferator-activated receptor Υ and suppresses skeletal muscle regeneration.
Submit: New GeneRIF Correction See all GeneRIFs (35)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to organic cyclic compound IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within dendritic spine development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of endothelial cell apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase PAK 4
Names
PAK-4
p21 protein (Cdc42/Rac)-activated kinase 4
p21-activated kinase 4
NP_081746.1
XP_017167785.1
XP_017167786.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027470.3 → NP_081746.1  serine/threonine-protein kinase PAK 4

    See identical proteins and their annotated locations for NP_081746.1

    Status: VALIDATED

    Source sequence(s)
    AC136456, AK017713, BB839524, BQ572351, BY197606, CF172418
    Consensus CDS
    CCDS21049.1
    UniProtKB/Swiss-Prot
    Q6ZPX0, Q80Z97, Q8BTW9, Q9CS71
    Related
    ENSMUSP00000103918.2, ENSMUST00000108283.8
    Conserved Domains (2) summary
    cd01093
    Location:10 → 48
    CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    cl21453
    Location:302 → 593
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    28258244..28297609 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312296.1 → XP_017167785.1  serine/threonine-protein kinase PAK 4 isoform X1

    UniProtKB/Swiss-Prot
    Q6ZPX0, Q80Z97, Q8BTW9, Q9CS71
    Conserved Domains (2) summary
    cd01093
    Location:10 → 48
    CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    cl21453
    Location:302 → 593
    PKc_like; Protein Kinases, catalytic domain

  2. XM_017312297.1 → XP_017167786.1  serine/threonine-protein kinase PAK 4 isoform X1

    UniProtKB/Swiss-Prot
    Q6ZPX0, Q80Z97, Q8BTW9, Q9CS71
    Related
    ENSMUSP00000032823.5, ENSMUST00000032823.5
    Conserved Domains (2) summary
    cd01093
    Location:10 → 48
    CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    cl21453
    Location:302 → 593
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BTW9.1 GenPept UniProtKB/Swiss-Prot:Q8BTW9

Gene LinkOut

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