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PCSK5 proprotein convertase subtilisin/kexin type 5 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 704428, updated on 17-Aug-2024

Summary

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Official Symbol
PCSK5provided by VGNC
Official Full Name
proprotein convertase subtilisin/kexin type 5provided by VGNC
Primary source
VGNC:VGNC:75787
See related
Ensembl:ENSMMUG00000022023
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See PCSK5 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
42
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 15 NC_041768.1 (91310257..91777275)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 15 NC_027907.1 (92159167..92627451)

Chromosome 15 - NC_041768.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114672673 Neighboring gene cell division cycle-associated protein 7-like Neighboring gene pre-mRNA-splicing factor RBM22-like Neighboring gene uncharacterized LOC114672819 Neighboring gene U7 small nuclear RNA Neighboring gene uncharacterized LOC106993801 Neighboring gene glucosaminyl (N-acetyl) transferase 1 Neighboring gene riboflavin kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in peptide hormone processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in trans-Golgi network IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
proprotein convertase subtilisin/kexin type 5

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041768.1 Reference Mmul_10 Primary Assembly

    Range
    91310257..91777275
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015117916.2 → XP_014973402.2  proprotein convertase subtilisin/kexin type 5 isoform X2

    UniProtKB/TrEMBL
    A0A1D5R646, A0A5F8AHI0
    Related
    ENSMMUP00000055784.2, ENSMMUT00000066080.2
    Conserved Domains (7) summary
    pfam03302
    Location:842 → 1213
    VSP; Giardia variant-specific surface protein
    cd04059
    Location:126 → 420
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:782 → 823
    FU; Furin-like repeats
    pfam14843
    Location:635 → 744
    GF_recep_IV; Growth factor receptor domain IV
    pfam15913
    Location:1211 → 1278
    Furin-like_2; Furin-like repeat, cysteine-rich
    pfam01483
    Location:505 → 595
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:38 → 114
    S8_pro-domain; Peptidase S8 pro-domain

  2. XM_015117915.2 → XP_014973401.1  proprotein convertase subtilisin/kexin type 5 isoform X6

    UniProtKB/TrEMBL
    F7GVE9
    Related
    ENSMMUP00000029002.2, ENSMMUT00000030986.4
    Conserved Domains (7) summary
    cd04059
    Location:126 → 420
    Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:782 → 823
    FU; Furin-like repeats
    cd00064
    Location:688 → 738
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00082
    Location:162 → 445
    Peptidase_S8; Subtilase family
    pfam01483
    Location:505 → 595
    P_proprotein; Proprotein convertase P-domain
    pfam08686
    Location:886 → 910
    PLAC; PLAC (protease and lacunin) domain
    pfam16470
    Location:38 → 114
    S8_pro-domain; Peptidase S8 pro-domain

  3. XM_028835254.1 → XP_028691087.1  proprotein convertase subtilisin/kexin type 5 isoform X1

    UniProtKB/TrEMBL
    A0A5F8AHI0, F6V4M0
    Related
    ENSMMUP00000038998.3, ENSMMUT00000045958.3
    Conserved Domains (7) summary
    pfam03302
    Location:681 → 1100
    VSP; Giardia variant-specific surface protein
    cd04059
    Location:126 → 420
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:1126 → 1161
    FU; Furin-like repeats
    cd00064
    Location:1209 → 1256
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam14843
    Location:635 → 744
    GF_recep_IV; Growth factor receptor domain IV
    pfam01483
    Location:505 → 595
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:38 → 114
    S8_pro-domain; Peptidase S8 pro-domain

  4. XM_028835255.1 → XP_028691088.1  proprotein convertase subtilisin/kexin type 5 isoform X3

    UniProtKB/TrEMBL
    A0A5F8AHI0
    Conserved Domains (8) summary
    pfam03302
    Location:1259 → 1544
    VSP; Giardia variant-specific surface protein
    PTZ00214
    Location:671 → 1025
    PTZ00214; high cysteine membrane protein Group 4; Provisional
    cd04059
    Location:126 → 420
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:1094 → 1129
    FU; Furin-like repeats
    cd00064
    Location:1177 → 1224
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam14843
    Location:1564 → 1681
    GF_recep_IV; Growth factor receptor domain IV
    pfam01483
    Location:505 → 595
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:38 → 114
    S8_pro-domain; Peptidase S8 pro-domain

  5. XM_028835256.1 → XP_028691089.1  proprotein convertase subtilisin/kexin type 5 isoform X4

    UniProtKB/TrEMBL
    A0A5F8AHI0
    Conserved Domains (7) summary
    pfam03302
    Location:643 → 1062
    VSP; Giardia variant-specific surface protein
    cd04059
    Location:111 → 382
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:1088 → 1123
    FU; Furin-like repeats
    cd00064
    Location:1171 → 1218
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam14843
    Location:597 → 706
    GF_recep_IV; Growth factor receptor domain IV
    pfam01483
    Location:467 → 557
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:38 → 99
    S8_pro-domain; Peptidase S8 pro-domain

  6. XM_028835259.1 → XP_028691092.1  proprotein convertase subtilisin/kexin type 5 isoform X7

    Conserved Domains (4) summary
    cd04059
    Location:126 → 420
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    pfam14843
    Location:635 → 729
    GF_recep_IV; Growth factor receptor domain IV
    pfam01483
    Location:505 → 595
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:38 → 114
    S8_pro-domain; Peptidase S8 pro-domain

  7. XM_028835258.1 → XP_028691091.1  proprotein convertase subtilisin/kexin type 5 isoform X5

    UniProtKB/TrEMBL
    G7NGC9
    Conserved Domains (7) summary
    pfam03302
    Location:949 → 1234
    VSP; Giardia variant-specific surface protein
    PTZ00214
    Location:368 → 715
    PTZ00214; high cysteine membrane protein Group 4; Provisional
    smart00261
    Location:784 → 819
    FU; Furin-like repeats
    cd00064
    Location:1155 → 1203
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam14843
    Location:293 → 402
    GF_recep_IV; Growth factor receptor domain IV
    pfam01483
    Location:163 → 253
    P_proprotein; Proprotein convertase P-domain
    cl10459
    Location:29 → 78
    Peptidases_S8_S53; Peptidase domain in the S8 and S53 families

  8. XM_028835257.1 → XP_028691090.1  proprotein convertase subtilisin/kexin type 5 isoform X5

    UniProtKB/TrEMBL
    G7NGC9
    Conserved Domains (7) summary
    pfam03302
    Location:949 → 1234
    VSP; Giardia variant-specific surface protein
    PTZ00214
    Location:368 → 715
    PTZ00214; high cysteine membrane protein Group 4; Provisional
    smart00261
    Location:784 → 819
    FU; Furin-like repeats
    cd00064
    Location:1155 → 1203
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam14843
    Location:293 → 402
    GF_recep_IV; Growth factor receptor domain IV
    pfam01483
    Location:163 → 253
    P_proprotein; Proprotein convertase P-domain
    cl10459
    Location:29 → 78
    Peptidases_S8_S53; Peptidase domain in the S8 and S53 families
Nucleotide Protein
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