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Copb1 coatomer protein complex, subunit beta 1 [ Mus musculus (house mouse) ]

Gene ID: 70349, updated on 2-Nov-2024

Summary

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Official Symbol
Copb1provided by MGI
Official Full Name
coatomer protein complex, subunit beta 1provided by MGI
Primary source
MGI:MGI:1917599
See related
Ensembl:ENSMUSG00000030754 AllianceGenome:MGI:1917599
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610019B04Rik
Summary
Predicted to enable structural molecule activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and intra-Golgi vesicle-mediated transport. Located in COPI-coated vesicle and Golgi apparatus. Is expressed in neocortex; sensory organ; and skeleton. Orthologous to human COPB1 (COPI coat complex subunit beta 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in placenta adult (RPKM 44.6), limb E14.5 (RPKM 34.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Copb1 in Genome Data Viewer
Location:
7 F1; 7 59.31 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (113814794..113853915, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (114215559..114254680, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene spondin 1, (f-spondin) extracellular matrix protein Neighboring gene STARR-positive B cell enhancer ABC_E6588 Neighboring gene STARR-positive B cell enhancer ABC_E8937 Neighboring gene predicted gene, 51454 Neighboring gene STARR-positive B cell enhancer ABC_E9298 Neighboring gene related RAS viral (r-ras) oncogene 2 Neighboring gene STARR-seq mESC enhancer starr_19925 Neighboring gene predicted gene, 53365 Neighboring gene STARR-seq mESC enhancer starr_19926 Neighboring gene STARR-positive B cell enhancer ABC_E4966 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:121419678-121419787 Neighboring gene STARR-positive B cell enhancer ABC_E9299 Neighboring gene STARR-positive B cell enhancer ABC_E10466 Neighboring gene STARR-positive B cell enhancer mm9_chr7:121444899-121445200 Neighboring gene RIKEN cDNA 4933406I18 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:121461019-121461282 Neighboring gene STARR-positive B cell enhancer ABC_E11365 Neighboring gene STARR-seq mESC enhancer starr_19927 Neighboring gene proteasome subunit alpha 1 Neighboring gene STARR-positive B cell enhancer ABC_E3745 Neighboring gene phosphodiesterase 3B, cGMP-inhibited

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ARF1-regulated coatomer directs the steady-state localization of protein kinase C epsilon at the Golgi apparatus. Peterson TA, et al. Biochim Biophys Acta, 2013 Mar. PMID 23195223, Free PMC Article
  2. Copb1-facilitated axonal transport and translation of kappa opioid-receptor mRNA. Bi J, et al. Proc Natl Acad Sci U S A, 2007 Aug 21. PMID 17698811, Free PMC Article
  3. cDNA sequence and mapping of the mouse Copb gene encoding the beta subunit of the COPI coatomer complex. LI W, et al. Somat Cell Mol Genet, 1999 May. PMID 11441537
  4. Novel Golgi protein, GoPro49, is a specific dental follicle marker. Takatalo MS, et al. J Dent Res, 2009 Jun. PMID 19587158
  5. GATE-16, a membrane transport modulator, interacts with NSF and the Golgi v-SNARE GOS-28. Sagiv Y, et al. EMBO J, 2000 Apr 3. PMID 10747018, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intra-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intra-Golgi vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
involved_in intra-Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of COPI vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COPI vesicle coat IEA
Inferred from Electronic Annotation
more info
  
part_of COPI vesicle coat ISO
Inferred from Sequence Orthology
more info
  
located_in COPI-coated vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi-associated vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
coatomer subunit beta
Names
beta-COP
beta-coat protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033370.3 → NP_203534.1  coatomer subunit beta

    See identical proteins and their annotated locations for NP_203534.1

    Status: PROVISIONAL

    Source sequence(s)
    AC161930
    Consensus CDS
    CCDS21759.1
    UniProtKB/Swiss-Prot
    Q3T9Y4, Q3TT72, Q3U8G9, Q3UE02, Q9JIF7
    Related
    ENSMUSP00000033012.8, ENSMUST00000033012.9
    Conserved Domains (4) summary
    sd00044
    Location:137 → 161
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:18 → 550
    Adaptin_N; Adaptin N terminal region
    pfam07718
    Location:667 → 807
    Coatamer_beta_C; Coatomer beta C-terminal region
    pfam14806
    Location:813 → 944
    Coatomer_b_Cpla; Coatomer beta subunit appendage platform

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    113814794..113853915 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JIF7.1 GenPept UniProtKB/Swiss-Prot:Q9JIF7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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