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CRH corticotropin releasing hormone [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 702877, updated on 17-Aug-2024

Summary

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Official Symbol
CRHprovided by VGNC
Official Full Name
corticotropin releasing hormoneprovided by VGNC
Primary source
VGNC:VGNC:71490
See related
Ensembl:ENSMMUG00000021587
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See CRH in Genome Data Viewer
Location:
chromosome: 8
Exon count:
2
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 8 NC_041761.1 (66821292..66823589, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 8 NC_027900.1 (64314498..64316818, complement)

Chromosome 8 - NC_041761.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114680268 Neighboring gene transfer RNA alanine (anticodon AGC) Neighboring gene tripartite motif containing 55 Neighboring gene uncharacterized LOC114680269 Neighboring gene ribosome biogenesis regulator 1 homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Overexpressing Corticotropin-Releasing Factor in the Primate Amygdala Increases Anxious Temperament and Alters Its Neural Circuit. Kalin NH, et al. Biol Psychiatry, 2016 Sep 1. PMID 27016385, Free PMC Article
  2. Functional CRH variation increases stress-induced alcohol consumption in primates. Barr CS, et al. Proc Natl Acad Sci U S A, 2009 Aug 25. PMID 19706546, Free PMC Article
  3. CRH haplotype as a factor influencing cerebrospinal fluid levels of corticotropin-releasing hormone, hypothalamic-pituitary-adrenal axis activity, temperament, and alcohol consumption in rhesus macaques. Barr CS, et al. Arch Gen Psychiatry, 2008 Aug. PMID 18678798, Free PMC Article
  4. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results of this study indicated that chronic CRF overexpression in primates not only increases Anxious Temperament but also affects metabolism and connectivity within components of Anxious Temperament 's neural circuitry.
    Title: Overexpressing Corticotropin-Releasing Factor in the Primate Amygdala Increases Anxious Temperament and Alters Its Neural Circuit.
  2. Data suggest that CRH promoter variation that confers increased stress reactivity increases the risk for alcohol use disorders in stress-exposed individuals.
    Title: Functional CRH variation increases stress-induced alcohol consumption in primates.
  3. We show that -2232C>G alters DNA x protein interactions and confers decreased sensitivity of the CRH promoter to glucocorticoids in vitro.
    Title: CRH haplotype as a factor influencing cerebrospinal fluid levels of corticotropin-releasing hormone, hypothalamic-pituitary-adrenal axis activity, temperament, and alcohol consumption in rhesus macaques.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables corticotropin-releasing hormone activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of epinephrine secretion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of glucagon secretion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cortisol secretion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
corticoliberin
Names
corticoliberin preproprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041761.1 Reference Mmul_10 Primary Assembly

    Range
    66821292..66823589 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001094433.4 → XP_001094433.1  corticoliberin

    See identical proteins and their annotated locations for XP_001094433.1

    UniProtKB/TrEMBL
    F7E8Q2, G8F161
    Related
    ENSMMUP00000028431.2, ENSMMUT00000030381.4
    Conserved Domains (1) summary
    pfam00473
    Location:157 → 194
    CRF; Corticotropin-releasing factor family
Nucleotide Protein
Heading Accession and Version

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Molecular Biology Databases
Research Materials