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DICER1 dicer 1, ribonuclease III [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 702516, updated on 17-Aug-2024

Summary

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Official Symbol
DICER1provided by VGNC
Official Full Name
dicer 1, ribonuclease IIIprovided by VGNC
Primary source
VGNC:VGNC:71638
See related
Ensembl:ENSMMUG00000023305
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See DICER1 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
33
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 7 NC_041760.1 (157272988..157344317, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 7 NC_027899.1 (157354224..157425528, complement)

Chromosome 7 - NC_041760.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L15-like Neighboring gene goosecoid homeobox Neighboring gene microRNA mir-3173 Neighboring gene calmin Neighboring gene uncharacterized LOC106999560

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables deoxyribonuclease I activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ribonuclease III activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic DNA fragmentation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in pre-miRNA processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in siRNA processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of RISC complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
endoribonuclease Dicer
NP_001244801.1
XP_014999915.1
XP_014999916.1
XP_014999917.1
XP_028706126.1
XP_028706127.1
XP_028706128.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001257872.1 → NP_001244801.1  endoribonuclease Dicer

    See identical proteins and their annotated locations for NP_001244801.1

    Status: PROVISIONAL

    Source sequence(s)
    JU333682
    UniProtKB/TrEMBL
    A0A5F7ZPU4, F6SLC3, F7FAP2
    Related
    ENSMMUP00000032603.1, ENSMMUT00000039532.3
    Conserved Domains (7) summary
    smart00535
    Location:1294 → 1385
    RIBOc; Ribonuclease III family
    COG0571
    Location:1664 → 1916
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:886 → 1008
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    cd15903
    Location:271 → 365
    Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    pfam03368
    Location:630 → 718
    Dicer_dimer; Dicer dimerization domain
    cd18802
    Location:372 → 564
    SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
    cd18034
    Location:42 → 239
    DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041760.1 Reference Mmul_10 Primary Assembly

    Range
    157272988..157344317 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015144431.2 → XP_014999917.1  endoribonuclease Dicer isoform X1

    UniProtKB/TrEMBL
    A0A5F7ZPU4, F6SLC3, F7FAP2
    Related
    ENSMMUP00000072640.1, ENSMMUT00000106317.1
    Conserved Domains (7) summary
    smart00535
    Location:1294 → 1385
    RIBOc; Ribonuclease III family
    COG0571
    Location:1664 → 1916
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:886 → 1008
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    cd15903
    Location:271 → 365
    Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    pfam03368
    Location:630 → 718
    Dicer_dimer; Dicer dimerization domain
    cd18802
    Location:372 → 564
    SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
    cd18034
    Location:42 → 239
    DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer

  2. XM_015144429.2 → XP_014999915.1  endoribonuclease Dicer isoform X1

    UniProtKB/TrEMBL
    A0A5F7ZPU4, F6SLC3, F7FAP2
    Conserved Domains (7) summary
    smart00535
    Location:1294 → 1385
    RIBOc; Ribonuclease III family
    COG0571
    Location:1664 → 1916
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:886 → 1008
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    cd15903
    Location:271 → 365
    Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    pfam03368
    Location:630 → 718
    Dicer_dimer; Dicer dimerization domain
    cd18802
    Location:372 → 564
    SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
    cd18034
    Location:42 → 239
    DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer

  3. XM_028850293.1 → XP_028706126.1  endoribonuclease Dicer isoform X1

    UniProtKB/TrEMBL
    A0A5F7ZPU4, F6SLC3, F7FAP2
    Conserved Domains (7) summary
    smart00535
    Location:1294 → 1385
    RIBOc; Ribonuclease III family
    COG0571
    Location:1664 → 1916
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:886 → 1008
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    cd15903
    Location:271 → 365
    Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    pfam03368
    Location:630 → 718
    Dicer_dimer; Dicer dimerization domain
    cd18802
    Location:372 → 564
    SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
    cd18034
    Location:42 → 239
    DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer

  4. XM_028850295.1 → XP_028706128.1  endoribonuclease Dicer isoform X1

    UniProtKB/TrEMBL
    A0A5F7ZPU4, F6SLC3, F7FAP2
    Conserved Domains (7) summary
    smart00535
    Location:1294 → 1385
    RIBOc; Ribonuclease III family
    COG0571
    Location:1664 → 1916
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:886 → 1008
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    cd15903
    Location:271 → 365
    Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    pfam03368
    Location:630 → 718
    Dicer_dimer; Dicer dimerization domain
    cd18802
    Location:372 → 564
    SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
    cd18034
    Location:42 → 239
    DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer

  5. XM_028850294.1 → XP_028706127.1  endoribonuclease Dicer isoform X1

    UniProtKB/TrEMBL
    A0A5F7ZPU4, F6SLC3, F7FAP2
    Conserved Domains (7) summary
    smart00535
    Location:1294 → 1385
    RIBOc; Ribonuclease III family
    COG0571
    Location:1664 → 1916
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:886 → 1008
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    cd15903
    Location:271 → 365
    Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    pfam03368
    Location:630 → 718
    Dicer_dimer; Dicer dimerization domain
    cd18802
    Location:372 → 564
    SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
    cd18034
    Location:42 → 239
    DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer

  6. XM_015144430.2 → XP_014999916.1  endoribonuclease Dicer isoform X1

    UniProtKB/TrEMBL
    A0A5F7ZPU4, F6SLC3, F7FAP2
    Conserved Domains (7) summary
    smart00535
    Location:1294 → 1385
    RIBOc; Ribonuclease III family
    COG0571
    Location:1664 → 1916
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:886 → 1008
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    cd15903
    Location:271 → 365
    Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    pfam03368
    Location:630 → 718
    Dicer_dimer; Dicer dimerization domain
    cd18802
    Location:372 → 564
    SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
    cd18034
    Location:42 → 239
    DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
Nucleotide Protein
Heading Accession and Version

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