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Dazap1 DAZ associated protein 1 [ Mus musculus (house mouse) ]

Gene ID: 70248, updated on 2-Nov-2024

Summary

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Official Symbol
Dazap1provided by MGI
Official Full Name
DAZ associated protein 1provided by MGI
Primary source
MGI:MGI:1917498
See related
Ensembl:ENSMUSG00000069565 AllianceGenome:MGI:1917498
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mPrrp; 2410042M16Rik
Summary
Enables RNA stem-loop binding activity. Acts upstream of or within several processes, including fibroblast proliferation; maternal placenta development; and positive regulation of mRNA splicing, via spliceosome. Located in cytoplasm and male germ cell nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human DAZAP1 (DAZ associated protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in limb E14.5 (RPKM 42.4), duodenum adult (RPKM 40.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dazap1 in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80097168..80124242)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80261362..80288408)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA asparagine 7 (anticodon GTT) Neighboring gene NADH:ubiquinone oxidoreductase core subunit S7 Neighboring gene STARR-positive B cell enhancer ABC_E5153 Neighboring gene STARR-positive B cell enhancer ABC_E10627 Neighboring gene guanidinoacetate methyltransferase Neighboring gene microRNA 6911 Neighboring gene predicted gene 15122 Neighboring gene STARR-positive B cell enhancer ABC_E5154 Neighboring gene ribosomal protein S15 Neighboring gene APC regulator of WNT signaling pathway 2 Neighboring gene STARR-positive B cell enhancer ABC_E8347 Neighboring gene RIKEN cDNA 2310011J03 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DAZAP1 regulates the splicing of Crem, Crisp2 and Pot1a transcripts. Chen HY, et al. Nucleic Acids Res, 2013 Nov. PMID 23965306, Free PMC Article
  2. The RNA ligands for mouse proline-rich RNA-binding protein (mouse Prrp) contain two consensus sequences in separate loop structure. Hori T, et al. Nucleic Acids Res, 2005. PMID 15647502, Free PMC Article
  3. Dynamic changes in intranuclear and subcellular localizations of mouse Prrp/DAZAP1 during spermatogenesis: the necessity of the C-terminal proline-rich region for nuclear import and localization. Kurihara Y, et al. Arch Histol Cytol, 2004 Nov. PMID 15700540
  4. DAZAP1, an hnRNP protein, is required for normal growth and spermatogenesis in mice. Hsu LC, et al. RNA, 2008 Sep. PMID 18669443, Free PMC Article
  5. Differential translation of Dazap1 transcripts during spermatogenesis. Yang CK, et al. PLoS One, 2013. PMID 23658607, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of Crem, Crisp2 and Pot1a as the natural substrates of DAZAP1 and show that DAZAP1 promotes the inclusion of specific exons in these genes.
    Title: DAZAP1 regulates the splicing of Crem, Crisp2 and Pot1a transcripts.
  2. The translation of the two Dazap1 transcripts is differentially regulated during spermatogenesis.
    Title: Differential translation of Dazap1 transcripts during spermatogenesis.
  3. DAZAP1 is not only essential for spermatogenesis, but also required for the normal growth and development of mice.
    Title: DAZAP1, an hnRNP protein, is required for normal growth and spermatogenesis in mice.
  4. Dynamic changes in intranuclear and subcellular localizations of DAZAP1 during spermatogenesis have been studied.
    Title: Dynamic changes in intranuclear and subcellular localizations of mouse Prrp/DAZAP1 during spermatogenesis: the necessity of the C-terminal proline-rich region for nuclear import and localization.
  5. Identification of RNA consensus sequences required for binding to DAZAP1.
    Title: The RNA ligands for mouse proline-rich RNA-binding protein (mouse Prrp) contain two consensus sequences in separate loop structure.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables RNA stem-loop binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(G) binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(G) binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(G) binding ISO
Inferred from Sequence Orthology
more info
  
enables poly(U) RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(U) RNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within maternal placenta development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DAZ-associated protein 1
Names
deleted in azoospermia-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122604.2 → NP_001116076.1  DAZ-associated protein 1 isoform b

    See identical proteins and their annotated locations for NP_001116076.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the 5' coding region, compared to variant 1. The resulting isoform (b) has an additional aa in the N-terminal region, compared to isoform a.
    Source sequence(s)
    AC140229
    Consensus CDS
    CCDS48626.1
    UniProtKB/Swiss-Prot
    Q9JII5
    UniProtKB/TrEMBL
    Q3U878
    Related
    ENSMUSP00000089958.6, ENSMUST00000092305.6
    Conserved Domains (2) summary
    cd12327
    Location:111 → 190
    RRM2_DAZAP1; RNA recognition motif 2 (RRM2) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
    cd12574
    Location:11 → 92
    RRM1_DAZAP1; RNA recognition motif 1 (RRM1) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins

  2. NM_001122605.2 → NP_001116077.1  DAZ-associated protein 1 isoform c

    See identical proteins and their annotated locations for NP_001116077.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (c) has an additional aa in the C-terminal region, compared to isoform a.
    Source sequence(s)
    AC140229
    Consensus CDS
    CCDS48627.1
    UniProtKB/TrEMBL
    Q3U878, Q3UGB5
    Related
    ENSMUSP00000101000.4, ENSMUST00000105361.10
    Conserved Domains (2) summary
    cd12327
    Location:110 → 189
    RRM2_DAZAP1; RNA recognition motif 2 (RRM2) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
    cd12574
    Location:11 → 92
    RRM1_DAZAP1; RNA recognition motif 1 (RRM1) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins

  3. NM_001378995.1 → NP_001365924.1  DAZ-associated protein 1 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (d).
    Source sequence(s)
    AC140229
    UniProtKB/TrEMBL
    Q3U878
    Conserved Domains (2) summary
    cd12327
    Location:111 → 190
    RRM2_DAZAP1; RNA recognition motif 2 (RRM2) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
    cd12574
    Location:11 → 92
    RRM1_DAZAP1; RNA recognition motif 1 (RRM1) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins

  4. NM_133188.3 → NP_573451.2  DAZ-associated protein 1 isoform a

    See identical proteins and their annotated locations for NP_573451.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AC140229
    Consensus CDS
    CCDS35977.1
    UniProtKB/TrEMBL
    Q3U878
    Related
    ENSMUSP00000101001.2, ENSMUST00000105362.8
    Conserved Domains (2) summary
    cd12327
    Location:110 → 189
    RRM2_DAZAP1; RNA recognition motif 2 (RRM2) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
    cd12574
    Location:11 → 92
    RRM1_DAZAP1; RNA recognition motif 1 (RRM1) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins

RNA

  1. NR_166396.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC140229

  2. NR_166397.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC140229

  3. NR_166398.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC140229

  4. NR_166399.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC140229

  5. NR_166400.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC140229

  6. NR_166401.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC140229

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    80097168..80124242
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245259.2 → XP_030101119.1  DAZ-associated protein 1 isoform X4

    UniProtKB/TrEMBL
    Q3U878
    Conserved Domains (2) summary
    cd12327
    Location:102 → 181
    RRM2_DAZAP1; RNA recognition motif 2 in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
    cd12574
    Location:3 → 84
    RRM1_DAZAP1; RNA recognition motif 1 in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins

  2. XM_006514070.5 → XP_006514133.1  DAZ-associated protein 1 isoform X1

    UniProtKB/TrEMBL
    Q3U878
    Conserved Domains (2) summary
    cd12327
    Location:103 → 182
    RRM2_DAZAP1; RNA recognition motif 2 in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
    cd12574
    Location:3 → 84
    RRM1_DAZAP1; RNA recognition motif 1 in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins

  3. XM_030245258.2 → XP_030101118.1  DAZ-associated protein 1 isoform X2

    UniProtKB/TrEMBL
    Q3U878
    Conserved Domains (2) summary
    cd12327
    Location:103 → 182
    RRM2_DAZAP1; RNA recognition motif 2 (RRM2) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
    cd12574
    Location:3 → 84
    RRM1_DAZAP1; RNA recognition motif 1 (RRM1) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins

  4. XM_006514071.4 → XP_006514134.1  DAZ-associated protein 1 isoform X3

    UniProtKB/TrEMBL
    Q3U878
    Conserved Domains (2) summary
    cd12327
    Location:102 → 181
    RRM2_DAZAP1; RNA recognition motif 2 in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
    cd12574
    Location:3 → 84
    RRM1_DAZAP1; RNA recognition motif 1 in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins

  5. XM_036155992.1 → XP_036011885.1  DAZ-associated protein 1 isoform X5

    Conserved Domains (1) summary
    cl17169
    Location:1 → 47
    RRM_SF; RNA recognition motif (RRM) superfamily

  6. XM_006514072.5 → XP_006514135.1  DAZ-associated protein 1 isoform X5

    Conserved Domains (1) summary
    cl17169
    Location:1 → 47
    RRM_SF; RNA recognition motif (RRM) superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JII5.2 GenPept UniProtKB/Swiss-Prot:Q9JII5

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