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MLH3 mutL homolog 3 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 701482, updated on 17-Aug-2024

Summary

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Official Symbol
MLH3provided by VGNC
Official Full Name
mutL homolog 3provided by VGNC
Primary source
VGNC:VGNC:82187
See related
Ensembl:ENSMMUG00000002911
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See MLH3 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
14
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 7 NC_041760.1 (137128414..137164167, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 7 NC_027899.1 (137402656..137438005, complement)

Chromosome 7 - NC_041760.1Genomic Context describing neighboring genes Neighboring gene placental growth factor Neighboring gene eukaryotic translation initiation factor 2B subunit beta Neighboring gene U6 spliceosomal RNA Neighboring gene synapsin-2-like Neighboring gene uncharacterized LOC114679600 Neighboring gene acylphosphatase 1 Neighboring gene zinc finger C2HC-type containing 1C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP-dependent DNA damage sensor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables mismatched DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in mismatch repair IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of mismatch repair complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
DNA mismatch repair protein Mlh3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001257783.1 → NP_001244712.1  DNA mismatch repair protein Mlh3

    See identical proteins and their annotated locations for NP_001244712.1

    Status: PROVISIONAL

    Source sequence(s)
    JU333986
    UniProtKB/TrEMBL
    A0A5F7ZGI2, F7HAZ3
    Related
    ENSMMUP00000064701.1, ENSMMUT00000085079.1
    Conserved Domains (3) summary
    smart00853
    Location:1194 → 1373
    MutL_C; MutL C terminal dimerisation domain
    cd03486
    Location:206 → 349
    MutL_Trans_MLH3; MutL_Trans_MLH3: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to ...
    pfam02518
    Location:22 → 149
    HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041760.1 Reference Mmul_10 Primary Assembly

    Range
    137128414..137164167 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_028850280.1 → XP_028706113.1  DNA mismatch repair protein Mlh3 isoform X5

    UniProtKB/TrEMBL
    F7H1T6
    Related
    ENSMMUP00000003901.4, ENSMMUT00000004134.4
    Conserved Domains (3) summary
    smart00853
    Location:1126 → 1305
    MutL_C; MutL C terminal dimerisation domain
    cd03486
    Location:206 → 349
    MutL_Trans_MLH3; transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain ...
    cd16926
    Location:9 → 192
    HATPase_MutL-MLH-PMS-like; Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, human MutL homologs (MLH/ PMS), and related domains

  2. XM_015144121.2 → XP_014999607.1  DNA mismatch repair protein Mlh3 isoform X2

    UniProtKB/TrEMBL
    A0A5F8AS64
    Related
    ENSMMUP00000080795.1, ENSMMUT00000087718.1
    Conserved Domains (3) summary
    smart00853
    Location:1161 → 1340
    MutL_C; MutL C terminal dimerisation domain
    cd03486
    Location:206 → 349
    MutL_Trans_MLH3; MutL_Trans_MLH3: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to ...
    pfam02518
    Location:22 → 149
    HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

  3. XM_015144123.2 → XP_014999609.1  DNA mismatch repair protein Mlh3 isoform X4

    UniProtKB/TrEMBL
    F7H1T6
    Conserved Domains (3) summary
    smart00853
    Location:1159 → 1314
    MutL_C; MutL C terminal dimerisation domain
    cd03486
    Location:206 → 349
    MutL_Trans_MLH3; MutL_Trans_MLH3: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to ...
    pfam02518
    Location:22 → 149
    HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

  4. XM_015144122.2 → XP_014999608.1  DNA mismatch repair protein Mlh3 isoform X3

    UniProtKB/TrEMBL
    A0A5F7ZGI2, A0A5F8ACA3
    Related
    ENSMMUP00000074601.1, ENSMMUT00000103957.1
    Conserved Domains (3) summary
    smart00853
    Location:1159 → 1338
    MutL_C; MutL C terminal dimerisation domain
    cd03486
    Location:206 → 349
    MutL_Trans_MLH3; MutL_Trans_MLH3: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to ...
    pfam02518
    Location:22 → 149
    HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

  5. XM_015144120.2 → XP_014999606.1  DNA mismatch repair protein Mlh3 isoform X1

    UniProtKB/TrEMBL
    A0A5F7ZIN1
    Related
    ENSMMUP00000064474.1, ENSMMUT00000108706.1
    Conserved Domains (3) summary
    smart00853
    Location:1194 → 1349
    MutL_C; MutL C terminal dimerisation domain
    cd03486
    Location:206 → 349
    MutL_Trans_MLH3; MutL_Trans_MLH3: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to ...
    pfam02518
    Location:22 → 149
    HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

  6. XM_015144124.2 → XP_014999610.1  DNA mismatch repair protein Mlh3 isoform X6

    UniProtKB/TrEMBL
    A0A5F7ZGI2
    Conserved Domains (3) summary
    smart00853
    Location:1194 → 1278
    MutL_C; MutL C terminal dimerisation domain
    cd03486
    Location:206 → 349
    MutL_Trans_MLH3; MutL_Trans_MLH3: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to ...
    pfam02518
    Location:22 → 149
    HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

RNA

  1. XR_003730902.1 RNA Sequence

  2. XR_003730903.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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