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RVA_s10_gp1 NSP4 [ Rotavirus A ]

Gene ID: 7011361, updated on 18-Aug-2023

Summary

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Gene symbol
RVA_s10_gp1
Gene description
NSP4
Locus tag
RVA_s10_gp1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rotavirus A (strain: RVA/Simian-tc/ZAF/SA11-H96/1958/G3P5B[2], serotype: G3)
Lineage
Viruses; dsRNA viruses; Reoviridae; Sedoreovirinae; Rotavirus
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Genomic context

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Location:
segment: 10
Sequence:
NC_011504.2 (42..569)

NC_011504.2Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_011504.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sequence and structural analyses of NSP4 proteins from human group A rotavirus strains detected in Tunisia. Ben Hadj Fredj M, et al. Pathol Biol (Paris), 2014 Jun. PMID 24679587
  2. Molecular characterization of the NSP4 gene of human group A rotavirus strains circulating in Tunisia from 2006 to 2008. Ben Hadj Fredj M, et al. Infect Genet Evol, 2012 Jul. PMID 22406141
  3. The rotavirus enterotoxin (NSP4) promotes re-modeling of the intracellular microtubule network. Yang W, et al. Virus Res, 2012 Jan. PMID 22036730
  4. Rotavirus disrupts calcium homeostasis by NSP4 viroporin activity. Hyser JM, et al. mBio, 2010 Nov 30. PMID 21151776, Free PMC Article
  5. Expression of nonstructural rotavirus protein NSP4 mimics Ca2+ homeostasis changes induced by rotavirus infection in cultured cells. Díaz Y, et al. J Virol, 2008 Nov. PMID 18787006, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rotavirus nonstructural protein 4 (NSP4) was identified as the viral trigger for disrupted mitochondrial morphology. Severance of mitochondrial interconnections was found to be a dynamin-related protein 1 (Drp1)-dependent process resulting synergistically from augmented mitochondrial fission and attenuated mitochondrial fusion.
    Title: Rotaviral nonstructural protein 4 triggers dynamin-related protein 1-dependent mitochondrial fragmentation during infection.
  2. Phosphorylation and subsequent transient degradation of mitochondrial Hsp60 during early hours of rotavirus-SA11 infection resulted in inhibition of premature import of nonstructural protein 4 into mitochondria, thereby delaying early apoptosis.
    Title: Tyrosine phosphorylation modulates mitochondrial chaperonin Hsp60 and delays rotavirus NSP4-mediated apoptotic signaling in host cells.
  3. 46 RVA strains were sequenced to determine the AA differences between E1 and E2 genotypes. Most were point mutations in the VP4-binding, the interspecies variable domain and the double-layered particle binding domains.
    Title: Sequence and structural analyses of NSP4 proteins from human group A rotavirus strains detected in Tunisia.
  4. Activation of the endoplasmic reticulum STIM1 and store-operated calcium entry by rotavirus requires NSP4 viroporin activity.
    Title: Activation of the endoplasmic reticulum calcium sensor STIM1 and store-operated calcium entry by rotavirus requires NSP4 viroporin activity.
  5. This report represents the first investigation on the genetic diversity of RVA NSP4 genes in Tunisia from 2006 to 2008.Phylogenetic analysis of the Tunisian NSP4 nucleotide sequences revealed the presence of two NSP4 genotypes.
    Title: Molecular characterization of the NSP4 gene of human group A rotavirus strains circulating in Tunisia from 2006 to 2008.
  6. Expression of the rotavirus enterotoxin (NSP4) in transfected monkey kidney cells was found to result in a dramatic re-modeling of the microtubule network.
    Title: The rotavirus enterotoxin (NSP4) promotes re-modeling of the intracellular microtubule network.
  7. NSP4 viroporin activity establishes the mechanism for NSP4-mediated elevation of [Ca(2+)]cyto, a critical event that regulates rotavirus replication and virion assembly.
    Title: Rotavirus disrupts calcium homeostasis by NSP4 viroporin activity.
  8. These results indicate that glycosylated NSP4 is primarily responsible for altering the Ca(2+) homeostasis of infected cells through an initial increase of cell membrane permeability to Ca(2+).
    Title: Expression of nonstructural rotavirus protein NSP4 mimics Ca2+ homeostasis changes induced by rotavirus infection in cultured cells.
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General gene information

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Homology

General protein information

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Preferred Names
NSP4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_011504.2 Reference assembly

    Range
    42..569
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_002302223.1 NSP4 [Rotavirus A]

    See identical proteins and their annotated locations for YP_002302223.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    A2T3Q0
    UniProtKB/TrEMBL
    A0A2H4W8E2, A2T3P6, G4XR49, O92323
    Conserved Domains (1) summary
    pfam01452
    Location:1 → 173
    Rota_NSP4; Rotavirus non structural protein
Nucleotide Protein
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