Ube2q1 ubiquitin-conjugating enzyme E2Q family member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ube2q1provided by MGI
Official Full Name: ubiquitin-conjugating enzyme E2Q family member 1provided by MGI
Primary source: MGI:MGI:1917343
See related: Ensembl:ENSMUSG00000042572 AllianceGenome:MGI:1917343
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gtap; Ube2q; NICE-5; PRO3094; 1110002C01Rik; 2310012M18Rik
Summary: Enables ubiquitin conjugating enzyme activity. Acts upstream of or within several processes, including embryo implantation; prolactin secretion; and suckling behavior. Predicted to be located in cytosol and filopodium. Predicted to be active in nucleus. Is expressed in several structures, including 4-cell stage embryo; blastocyst; mammary gland; reproductive system; and spleen. Orthologous to human UBE2Q1 (ubiquitin conjugating enzyme E2 Q1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 15.4), CNS E11.5 (RPKM 14.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 39.19 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (89680905..89691304)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (89773609..89783997)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ube2q1 is not expressed in the uterus of non-pregnant females but its expression is up-regulated during pregnancy. Ube2q1 is involved in different aspects of female fertility.
Title: Embryo implantation failure and other reproductive defects in Ube2q1-deficient female mice.
GTAP functions as an evolutionarily conserved E2 enzyme, which may participate in intercellular adhesion and embryonic development.
Title: Characterization of a novel ubiquitin-conjugating enzyme that regulates beta1,4-galactosyltransferase-1 in embryonic stem cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI854014 (e-PCR)
- UniSTS:165265

NoName (e-PCR)
- UniSTS:482799

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin conjugating enzyme activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within embryo implantation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fertilization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within prolactin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within reproductive system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within suckling behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in filopodium	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ubiquitin-conjugating enzyme E2 Q1

Names: E2 ubiquitin-conjugating enzyme Q1; galactosyl transferase-associated protein; ubiquitin carrier protein Q1; ubiquitin-conjugating enzyme E2Q (putative) 1; ubiquitin-protein ligase Q1

NP_081591.3

EC 2.3.2.23

XP_036019192.1

EC 2.3.2.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027315.4 → NP_081591.3 ubiquitin-conjugating enzyme E2 Q1

See identical proteins and their annotated locations for NP_081591.3

Status: VALIDATED

Source sequence(s)

AC102392

Consensus CDS

CCDS17517.1

UniProtKB/Swiss-Prot

Q29ST1, Q3UIY3, Q6P913, Q7TSS2, Q80UT5, Q8K2T0, Q9D7E1

Related

ENSMUSP00000037939.9, ENSMUST00000038356.13

Conserved Domains (1) summary

cd00195
Location:253 → 409

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

89680905..89691304

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163299.1 → XP_036019192.1 ubiquitin-conjugating enzyme E2 Q1 isoform X1

Related

ENSMUSP00000143422.2, ENSMUST00000196726.2

Conserved Domains (1) summary

cd00195
Location:84 → 240

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...