Rsc1a1 regulatory solute carrier protein, family 1, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rsc1a1provided by MGI
Official Full Name: regulatory solute carrier protein, family 1, member 1provided by MGI
Primary source: MGI:MGI:3526447
See related: AllianceGenome:MGI:3526447
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rs1; 1700027M01Rik
Summary: Predicted to enable sodium channel inhibitor activity. Acts upstream of or within intestinal absorption and negative regulation of protein localization to plasma membrane. Located in brush border and membrane. Used to study obesity. Orthologous to human RSC1A1 (regulator of solute carriers 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human all
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Genomic context

Location:: 4 D3; 4 74.7 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (141410874..141413027, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (141683563..141685716, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rsc1A1 has a role in Na+-D-glucose cotransport in the small intestine through SGLT1 and in preventing obesity [Rsc1A1]
Title: Mice without the regulator gene Rsc1A1 exhibit increased Na+-D-glucose cotransport in small intestine and develop obesity.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sodium channel inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within intestinal absorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of D-glucose transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of Golgi to plasma membrane protein transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of nucleoside transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of nucleoside transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transport	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: regulatory solute carrier protein family 1 member 1

Names: regulatory subunit of SGLT1; transporter regulator RS1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.