CRIPTO3 cripto, EGF-CFC family member 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CRIPTO3provided by HGNC
Official Full Name: cripto, EGF-CFC family member 3provided by HGNC
Primary source: HGNC:HGNC:11703
See related: Ensembl:ENSG00000225366 AllianceGenome:HGNC:11703
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CR-3; TDGF2; TDGF3; CRIPTO; TDGF1P3; CRIPTO-3
Summary: The TDGF3 locus has characteristics of a retrotransposon, including lack of introns and a poly(A) sequence. [provided by RefSeq, Jul 2008]
Orthologs: all
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Genomic context

Location:: Xq23

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (110520896..110523021)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (108968800..108970925)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (109764124..109766249)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pseudogene TDGF1P3 regulates the proliferation and metastasis of colorectal cancer cells via the miR-338-3p-PKM2 axis.
Title: Pseudogene TDGF1P3 regulates the proliferation and metastasis of colorectal cancer cells via the miR-338-3p-PKM2 axis.
These data indicate that CRIPTO3 is an expressed gene, particularly in certain cancers, and suggest a potentially novel mechanism of oncogenesis through activation of a retrogene.
Title: CRIPTO3, a presumed pseudogene, is expressed in cancer.
CRIPTO-3, a processed pseudogene of CRIPTO-1 on the X chromosome, is expressed in undifferentiated NT2 cells and is regulated by germ cell nuclear factor in parallel to CRIPTO-1
Title: Germ cell nuclear factor is a repressor of CRIPTO-1 and CRIPTO-3.

Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

D8S2279 (e-PCR)
- UniSTS:473907

AL032578 (e-PCR)
- UniSTS:93252

RH79908 (e-PCR)
- UniSTS:92252

D11S3732 (e-PCR)
- UniSTS:152962

RH79926 (e-PCR)
- UniSTS:91531

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables activin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	NAS Non-traceable Author Statement more info	PubMed
enables nodal binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in anterior/posterior pattern specification	IBA Inferred from Biological aspect of Ancestor more info
involved_in blood vessel development	IBA Inferred from Biological aspect of Ancestor more info
involved_in determination of left/right symmetry	IBA Inferred from Biological aspect of Ancestor more info
involved_in heart development	IBA Inferred from Biological aspect of Ancestor more info
involved_in nodal signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: putative protein CRIPTO3

Names: Teratocarcinoma-derived growth factor-2; cripto-3 growth factor; epidermal growth factor-like cripto protein CR3; putative teratocarcinoma-derived growth factor 3; teratocarcinoma-derived growth factor 1 pseudogene 3; teratocarcinoma-derived growth factor 2 (retroposin, possibly expressed); teratocarcinoma-derived growth factor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001397362.1 → NP_001384291.1 putative protein CRIPTO3 precursor

Status: VALIDATED

Source sequence(s)

AC000113

Consensus CDS

CCDS94651.1

UniProtKB/Swiss-Prot

P51864

UniProtKB/TrEMBL

B2R8C7

Related

ENSP00000507999.1, ENST00000602699.2

Conserved Domains (2) summary

pfam09443
Location:115 → 149

CFC; Cripto_Frl-1_Cryptic (CFC)

cl17037
Location:147 → 183

NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily