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Exoc1 exocyst complex component 1 [ Mus musculus (house mouse) ]

Gene ID: 69940, updated on 2-Nov-2024

Summary

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Official Symbol
Exoc1provided by MGI
Official Full Name
exocyst complex component 1provided by MGI
Primary source
MGI:MGI:2445020
See related
Ensembl:ENSMUSG00000036435 AllianceGenome:MGI:2445020
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SEC3; Sec3p; Sec3l1; 2810407P21Rik; A730011E05Rik
Summary
Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity. Acts upstream of or within embryo implantation. Predicted to be located in cytoplasm. Predicted to be part of exocyst. Predicted to be active in plasma membrane. Is expressed in fronto-nasal process mesenchyme; mandibular process mesenchyme; and maxillary process mesenchyme. Orthologous to human EXOC1 (exocyst complex component 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E18 (RPKM 16.5), CNS E14 (RPKM 14.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Exoc1 in Genome Data Viewer
Location:
5 C3.3; 5 41.28 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (76677147..76718134)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (76529307..76570298)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13446 Neighboring gene STARR-seq mESC enhancer starr_13447 Neighboring gene predicted gene, 34175 Neighboring gene neuromedin U Neighboring gene exocyst complex component 1 like Neighboring gene STARR-positive B cell enhancer ABC_E1053 Neighboring gene centrosomal protein 135 Neighboring gene capping protein inhibiting regulator of actin Neighboring gene predicted gene, 57768 Neighboring gene ribosomal protein L23a pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Birth of mice from meiotically arrested spermatocytes following biparental meiosis in halved oocytes. Ogonuki N, et al. EMBO Rep, 2022 Jul 5. PMID 35587095, Free PMC Article
  2. EXOC1 plays an integral role in spermatogonia pseudopod elongation and spermatocyte stable syncytium formation in mice. Osawa Y, et al. Elife, 2021 May 11. PMID 33973520, Free PMC Article
  3. Peri-implantation lethality in mice carrying megabase-scale deletion on 5qc3.3 is caused by Exoc1 null mutation. Mizuno S, et al. Sci Rep, 2015 Sep 8. PMID 26346620, Free PMC Article
  4. Fibroproliferative response to urothelial failure obliterates the ureter lumen in a mouse model of prenatal congenital obstructive nephropathy. Lee AJ, et al. Sci Rep, 2016 Aug 11. PMID 27511831, Free PMC Article
  5. An Alternative Splicing Program for Mouse Craniofacial Development. Hooper JE, et al. Front Physiol, 2020. PMID 33013468, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. EXOC1 plays an integral role in spermatogonia pseudopod elongation and spermatocyte stable syncytium formation in mice.
    Title: EXOC1 plays an integral role in spermatogonia pseudopod elongation and spermatocyte stable syncytium formation in mice.
  2. Peri-implantation lethality in mice carrying megabase-scale deletion on 5qc3.3 is caused by Exoc1 null mutation
    Title: Peri-implantation lethality in mice carrying megabase-scale deletion on 5qc3.3 is caused by Exoc1 null mutation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Golgi to plasma membrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within embryo implantation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in membrane fission NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitotic cytokinesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle docking involved in exocytosis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in vesicle tethering involved in exocytosis NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Flemming body IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of exocyst IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of exocyst NAS
Non-traceable Author Statement
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
exocyst complex component 1
Names
SEC3-like 1
exocyst complex component Sec3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289770.2 → NP_001276699.1  exocyst complex component 1 isoform 2

    See identical proteins and their annotated locations for NP_001276699.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons and contains another alternate in-frame exon compared to variant 4. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 4.
    Source sequence(s)
    AC127332
    Consensus CDS
    CCDS71607.1
    UniProtKB/Swiss-Prot
    E9QQ24, Q8R3S6
    Related
    ENSMUSP00000084373.5, ENSMUST00000087133.11
    Conserved Domains (2) summary
    cd14683
    Location:3 → 120
    PH-EXOC1; PH-like domain of Exocyst complex component 1
    pfam09763
    Location:184 → 871
    Sec3_C; Exocyst complex component Sec3

  2. NM_001289771.2 → NP_001276700.1  exocyst complex component 1 isoform 3

    See identical proteins and their annotated locations for NP_001276700.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 4. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 4.
    Source sequence(s)
    AC127332
    Consensus CDS
    CCDS71608.1
    UniProtKB/TrEMBL
    Q5PPR2
    Related
    ENSMUSP00000046719.7, ENSMUST00000049469.13
    Conserved Domains (2) summary
    cd14683
    Location:3 → 120
    PH-EXOC1; PH-like domain of Exocyst complex component 1
    pfam09763
    Location:184 → 856
    Sec3_C; Exocyst complex component Sec3

  3. NM_001359370.2 → NP_001346299.1  exocyst complex component 1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (4).
    Source sequence(s)
    AC127332
    Conserved Domains (2) summary
    cd14683
    Location:3 → 120
    PH-EXOC1; PH-like domain of Exocyst complex component 1
    pfam09763
    Location:191 → 881
    Sec3_C; Exocyst complex component Sec3

  4. NM_001359372.2 → NP_001346301.1  exocyst complex component 1 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 4. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 4.
    Source sequence(s)
    AC127332
    Conserved Domains (2) summary
    cd14683
    Location:3 → 120
    PH-EXOC1; PH-like domain of Exocyst complex component 1
    pfam09763
    Location:191 → 863
    Sec3_C; Exocyst complex component Sec3

  5. NM_001359373.1 → NP_001346302.1  exocyst complex component 1 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 3' UTR and coding sequence compared to variant 4. The resulting isoform (6) has a shorter and distinct C-terminus compared to isoform 4.
    Source sequence(s)
    AC127332, AK042620
    Related
    ENSMUST00000137018.8
    Conserved Domains (1) summary
    cd14683
    Location:3 → 120
    PH-EXOC1; PH-like domain of Exocyst complex component 1

  6. NM_001401325.1 → NP_001388254.1  exocyst complex component 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC127332

  7. NM_001401326.1 → NP_001388255.1  exocyst complex component 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC127332

  8. NM_027270.3 → NP_081546.1  exocyst complex component 1 isoform 1

    See identical proteins and their annotated locations for NP_081546.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame exon and contains another alternate in-frame exon compared to variant 4. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 4.
    Source sequence(s)
    AC127332
    Consensus CDS
    CCDS39117.1
    UniProtKB/TrEMBL
    Q6P1Y9
    Related
    ENSMUSP00000109121.2, ENSMUST00000113493.8
    Conserved Domains (2) summary
    cd14683
    Location:3 → 120
    PH-EXOC1; PH-like domain of Exocyst complex component 1
    pfam09763
    Location:191 → 878
    Sec3_C; Exocyst complex component Sec3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    76677147..76718134
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165480.1 → XP_036021373.1  exocyst complex component 1 isoform X3

    Conserved Domains (2) summary
    cd14683
    Location:3 → 120
    PH-EXOC1; PH-like domain of Exocyst complex component 1
    pfam09763
    Location:184 → 889
    Sec3_C; Exocyst complex component Sec3

  2. XM_036165478.1 → XP_036021371.1  exocyst complex component 1 isoform X1

    Conserved Domains (2) summary
    cd14683
    Location:3 → 120
    PH-EXOC1; PH-like domain of Exocyst complex component 1
    pfam09763
    Location:195 → 900
    Sec3_C; Exocyst complex component Sec3

  3. XM_036165481.1 → XP_036021374.1  exocyst complex component 1 isoform X4

    Conserved Domains (2) summary
    cd14683
    Location:3 → 120
    PH-EXOC1; PH-like domain of Exocyst complex component 1
    pfam09763
    Location:195 → 885
    Sec3_C; Exocyst complex component Sec3

  4. XM_036165479.1 → XP_036021372.1  exocyst complex component 1 isoform X2

    Conserved Domains (2) summary
    cd14683
    Location:3 → 120
    PH-EXOC1; PH-like domain of Exocyst complex component 1
    pfam09763
    Location:191 → 896
    Sec3_C; Exocyst complex component Sec3

  5. XM_036165484.1 → XP_036021377.1  exocyst complex component 1 isoform X7

    Conserved Domains (1) summary
    cl19950
    Location:25 → 512
    Sec3_C; Exocyst complex component Sec3

  6. XM_036165485.1 → XP_036021378.1  exocyst complex component 1 isoform X7

    Conserved Domains (1) summary
    cl19950
    Location:25 → 512
    Sec3_C; Exocyst complex component Sec3

  7. XM_036165482.1 → XP_036021375.1  exocyst complex component 1 isoform X5

    Conserved Domains (2) summary
    cd14683
    Location:3 → 120
    PH-EXOC1; PH-like domain of Exocyst complex component 1
    pfam09763
    Location:195 → 882
    Sec3_C; Exocyst complex component Sec3

  8. XM_036165486.1 → XP_036021379.1  exocyst complex component 1 isoform X8

    Conserved Domains (1) summary
    cl19950
    Location:6 → 494
    Sec3_C; Exocyst complex component Sec3

  9. XM_036165487.1 → XP_036021380.1  exocyst complex component 1 isoform X9

    Conserved Domains (1) summary
    cl19950
    Location:6 → 479
    Sec3_C; Exocyst complex component Sec3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R3S6.4 GenPept UniProtKB/Swiss-Prot:Q8R3S6

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